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10-SEPTEMBER-2008 16:47:15 - Auranofin Auranofin Systematic IUPAC name gold+1 cation; 3,4,5-triacetyloxy-6- acetyloxymethyl oxane-2-thiolate; triethylphosphanium Identifiers CAS number 34031-32-8 ATC code M01CB03 PubChem 6333901 DrugBank APRD00808 Chemical data Formula C20H35AuO9PS+ Mol. mass 679.493 g/mol Pharmacokinetic data Bioavailability ? Metabolism ? Half life ? Excretion ? Therapeutic considerations Pregnancy cat. ? Legal status Routes ? Main article: Gold salts Auranofin is a organogold compound classified by the World Health Organization as an antirheumatic agent. It has the brand name Ridaura. See also Aurothioglucose Disodium aurothiomalate Sodium aurothiomalate External links MedlinePlus DrugInfo medmaster-a685038 Cochrane review - Auranofin versus placebo in rheumatoid arthritis Jeon K, Byun M, Jue D 2003. Gold compound auranofin inhibits IkappaB kinase IKK by modifying Cys-179 of IKKbeta subunit.. Exp Mol Med 35 2: 61-6. PMID 12754408. Kim I, Jin J, Lee I, Park S 2004. Auranofin induces apoptosis and when combined with retinoic acid enhances differentiation of acute promyelocytic leukaemia cells in vitro.. Br J Pharmacol 142 4: 749-55. doi:10.1038/sj.bjp.0705708. PMID 15159275. Venardos K, Harrison G, Headrick J, Perkins A. Auranofin increases apoptosis and ischaemia-reperfusion injury in the rat isolated heart.. Clin Exp Pharmacol Physiol 31 5-6: 289-94. doi:10.1111/j.1440-1681.2004.03993.x. PMID 15191400. Hafejee A, Winhoven S, Coulson I 2004. Jessner's lymphocytic infiltrate responding to oral auranofin.. J Dermatolog Treat 15 5: 331-2. doi:10.1080/09546630410016924. PMID 15370403. Rigobello M, Folda A, Baldoin M, Scutari G, Bindoli A 2005. Effect of auranofin on the mitochondrial generation of hydrogen peroxide. Role of thioredoxin reductase.. Free Radic Res 39 7: 687-95. doi:10.1080/10715760500135391. PMID 16036347. Tablets This pharmacology-related article is a stub. v d e Anti-inflammatory and antirheumatic products M01 Anti-inflammatory and antirheumatic products, non-steroids See also: NSAIDs Pyrazolidine/Butylpyrazolidines: · Ampyrone · Clofezone · Kebuzone · Metamizole · Mofebutazone · Oxyphenbutazone · Phenazone · Phenylbutazone · Sulfinpyrazone · Acetic acid derivatives and related substances: · Aceclofenac · Acemetacin · Alclofenac · Bromfenac · Bumadizone · Bufexamac · Diclofenac · Difenpiramide · Etodolac · Fentiazac · Indometacin · Ketorolac · Lonazolac · Oxametacin · Proglumetacin · Sulindac · Tolmetin · Zomepirac · Oxicams: · Ampiroxicam · Droxicam · Lornoxicam · Meloxicam · Piroxicam · Tenoxicam · Propionic acid derivatives: · Alminoprofen · Benoxaprofen · Dexibuprofen · Dexketoprofen · Fenbufen · Fenoprofen · Flunoxaprofen · Flurbiprofen · Ibuprofen · Ibuproxam · Indoprofen · Ketoprofen · Naproxen · Oxaprozin · Pirprofen · Suprofen · Tiaprofenic acid · Fenamates: · Flufenamic acid · Meclofenamic acid · Mefenamic acid · Tolfenamic acid · Coxibs: · Celecoxib · Etoricoxib · Lumiracoxib · Parecoxib · Rofecoxib · Valdecoxib · other anti-inflammatory and antirheumatic agents, non-steroids: · Nabumetone · Niflumic acid · Azapropazone · Glucosamine · Benzydamine · Glycosaminoglycan · Magnesium salicylate · Proquazone · Superoxide dismutase/Orgotein · Nimesulide · Feprazone · Diacerein · Morniflumate · Tenidap · Oxaceprol · Chondroitin sulfate · Specific antirheumatic agents Quinolines: · Oxycinchophen · Gold preparations: · Sodium aurothiomalate · Sodium aurothiosulfate · Auranofin · Aurothioglucose · Aurotioprol · Penicillamine/Bucillamine Retrieved from http://en..org/wiki/Auranofin Categories: Gold compounds | Immunosuppressive agents | Pharmacology stubs Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Türkçe Deutsch This page was last modified on 23 July 2008, at 20:40
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