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10-SEPTEMBER-2008 16:47:15 - Benzydamine Benzydamine Systematic IUPAC name 3-1-benzyl-1H-indazol-3-yloxy-N,N-dimethylpropan-1-amine Identifiers CAS number 642-72-8 ATC code A01AD02 G02CC03 M01AX07 M02AA05 PubChem 65464 Chemical data Formula C19H24N3O Mol. mass 282 Pharmacokinetic data Bioavailability ? Metabolism ? Half life ? Excretion ? Therapeutic considerations Pregnancy cat. ? Legal status Routes ? Benzydamine, available as the hydrochloride, is a locally-acting nonsteroidal anti-inflammatory drug with local anaesthetic and analgesic properties providing both rapid and extended pain relief as well as a significant anti-inflammatory treatment for the painful inflammatory conditions of the mouth and throat.1 It selectively binds to inflamed tissues Prostaglandin synthetase inhibitor is virtually free of any adverse systemic effects. It may be used alone or as an adjunct to other therapy giving the possibility of increased therapeutic effect with little risk of interaction. Contents 1 Availability 2 Indications 3 Contraindications 4 Side effects 5 Footnotes 6 External links Availability It is available in a mouth wash named Tantum Verde across Europe. In the UK it is sold by 3M under the trade name Difflam, as Difflam Spray, Difflam Oral Rinse and Difflam Cream. Its high cost about £7 a bottle makes it less attractive than the cheaper method of gargling aspirin. In Australia it is available from 3M as Difflam-C Alcohol Colour Free Solution, Difflam 3% Gel, Difflam Extra Strength Gel 5%, Difflam-C Solution, Difflam Solution including Difflam Throat Spray, Difflam Cream and Difflam Lozenges.2 It is sold in eastern Europe without prescription as Tantum Rosa - a vaginal antiseptic and antiinflammatory, containing 0.14 g of benzydamine hydrochloride to be reconstitued with clean water to a 0.1% 1 mg/mL solution for vaginal enema/instillation. In Brazil it is sold by prescription under the name Benflogin, with each box containing 20 pills 50mg each. In Pakistan it is sold by prescription under the name Tantum Capsule 50mg. It is available in a cream and gel named Tantum Fort across Egypt by EIPICo. It is available with prescription as a mouthwash named Novo-Benzydamine Novopharm in Canada. Indications Odontostomatology: gingivitis, stomatitis, glossitis, aphthous ulcers, dental surgery and oral ulceration due to radiation therapy. Otorhinolaryngology: pharyngitis, tonsillitis, post-tonsillectomy, radiation or intubation mucositis. Contraindications There are no contraindications to the use of Benzydamine except for known hypersensitivity. Side effects Benzydamine is well tolerated. Occasionally oral tissue numbness or stinging sensations may occur. Benzydamine may be abused recreationally.3 In oral dosages of 500 mg to 3000 mg it is a deliriant and CNS stimulant, popular in Poland and Brazil. In Brazil it is very popular and many people use it for recreational purposes. A person in a benzydamine trip may experience a feeling of well-being, euphoria and in higher doses will hallucinate, paranoia, dry mouth and convulsions may also be experienced. The trip can last up to 8 hours, after that the user becomes tired and quiet, but sleeping is almost impossible. Unlike other NSAIDs, it does not inhibit cyclooxygenase or lipooxygenase, and is not ulcerogenic. 3 Footnotes ^ Turnbull RS. Benzydamine Hydrochloride Tantum in the management of oral inflammatory conditions. Journal of the Canadian Dental Association. 1995 Feb;612:127-34. ^ Material Safety Data Sheets for Difflam varieties sold in Australia ^ a b Anand JS, Glebocka ML, Korolkiewicz RP. Recreational abuse with benzydamine hydrochloride tantum rosa. Clinical Toxicology Philadelphia, Pa. 2007;452:198-9. External links Medicinenet.com Net Doctor, UK v d e Stimulants Alkylamines Cyclopentamine Geranamine Isometheptene Octodrine Propylhexedrine Tuamine Alphapyrrolidinylalkiophenones α-PPP MDPPP MDPV MPBP MPHP MPPP MOPPP Pyrovalerone Cholinergics ABT-089 ABT-418 Anabasine Arecoline Cotinine Cytisine Dianicline Epibatidine Epiboxidine GTS-21 Ispronicline Nicotine Rivanicline Tebanicline Varenicline Convulsants Bicuculline DMCM Gabazine Pentetrazol Picrotoxin Strychnine Thujone Eugeroics Adrafinil Armodafinil Carphedon Modafinil Phenethylamines 4-Bromomethcathinone 4-Fluoroamphetamine 4-Fluoromethamphetamine 4-Fluoromethcathinone 4-Methylmethcathinone 4-MTA Aletamine Amfepentorex Amphechloral Amphetamine Dextroamphetamine, Adderall Amphetaminil Benzphetamine Bupropion Cathinone Chlorphentermine Clenbuterol Clobenzorex Clortermine Diethylpropion Dimethoxyamphetamine Dimethylamphetamine Dimethylcathinone Ephedrine Epinephrine Ethcathinone Ethylamphetamine Fenethylline Fenfluramine Fenproporex Fludorex Furfenorex Levomethamphetamine Lisdexamfetamine MDMA Mefenorex Methamphetamine Methcathinone Methoxyphedrine Methylone Octopamine Ortetamine Parahydroxyamphetamine PCA PIA PMA PMEA PMMA PPAP Phendimetrazine Phenmetrazine Phentermine Phenylephrine Phenylpropanolamine Propylamphetamine Pseudoephedrine Selegiline Synephrine Tiflorex Xylopropamine Phenylaminooxazoles 4-Methyl-aminorex Aminorex Clominorex Fenozolone Fluminorex Pemoline Thozalinone Piperazines 2C-B-BZP BZP GBR-12783 GBR-12935 GBR-13069 GBR-13098 GBR-13119 MeOPP MBZP Vanoxerine Piperidines 2-Benzylpiperidine Desoxypipradrol Diphemethoxidine Ethylphenidate HDMP-28 --Methyl-1-methyl-4β-2-naphthylpiperidine-3β-carboxylate Methylphenidate Dexmethylphenidate Nocaine Phacetoperane Pipradrol Tropanes 3α-Bis-4-fluorophenylmethoxytropane 3α-4-Chlorophenylphenylmethoxytropane 3-Pseudotropyl-4-fluorobenzoate Altropane IACFT Brasofensine CFT WIN 35,428 β-CIT RTI-55 Cocaethylene Cocaine β-CPPIT Dichloropane RTI-111 Difluoropine FE-β-CPPIT FP-β-CPPIT PIT PTT RTI-31 RTI-32 RTI-51 RTI-112 RTI-113 RTI-121 IPCIT RTI-126 RTI-150 RTI-171 RTI-177 RTI-336 Tesofensine Troparil β-CPT, WIN 35,065-2 WF-23 WF-33 WF-60 Xanthines Aminophylline Caffeine Dimethazan Paraxanthine Theobromine Theophylline Others Amineptine Bemegride Benzydamine BPAP Bromantane BTQ Clofenciclan Cypenamine Cyprodenate Diclofensine Dimethocaine Diphenyl prolinol Ethamivan Fencamfamine Feprosidnine Gilutensin GYKI-52895 Hexacyclonate Indanorex Indatraline LR-5182 Mazindol Mesocarb Naphthylisopropylamine Nikethamide Nomifensine Phthalimidopropiophenone Prolintane Sibutramine Yohimbine Zylofuramine See also Sympathomimetic amines v d e Deliriants anticholinergic hallucinogens Tropanes Atropine, Hyoscyamine, Scopolamine Benzilates Benactyzine, Ditran, EA-3167, N-Ethyl-3-piperidyl benzilate, N-Methyl-3-piperidyl benzilate, 3-Quinuclidinyl benzilate Antihistamines Benzhydryl compounds Cyclizine, Dimenhydrinate, Diphenhydramine, Doxylamine, Promethazine Others Benzydamine, Dicyclomine, Biperiden, Trihexyphenidyl v d e Stomatological preparations A01 Caries prophylactic agents Sodium fluoride - Sodium monofluorophosphate - Olaflur - Stannous fluoride Anti-infectives and antiseptics Hydrogen peroxide - Chlorhexidine - Amphotericin B - Polynoxylin - Domiphen - Oxyquinoline - Neomycin - Miconazole - Natamycin - Hexetidine - Tetracycline - Benzoxonium chloride - Tibezonium iodide - Mepartricin - Metronidazole - Clotrimazole - Sodium perborate - Chlortetracycline - Doxycycline - Minocycline - Eugenol Corticosteroids Glucocorticoids Triamcinolone - Dexamethasone - Hydrocortisone Other Epinephrine/Adrenalone - Benzydamine - Acetylsalicylic acid - Amlexanox v d e Anti-inflammatory and antirheumatic products M01 Anti-inflammatory and antirheumatic products, non-steroids See also: NSAIDs Pyrazolidine/Butylpyrazolidines: · Ampyrone · Clofezone · Kebuzone · Metamizole · Mofebutazone · Oxyphenbutazone · Phenazone · Phenylbutazone · Sulfinpyrazone · Acetic acid derivatives and related substances: · Aceclofenac · Acemetacin · Alclofenac · Bromfenac · Bumadizone · Bufexamac · Diclofenac · Difenpiramide · Etodolac · Fentiazac · Indometacin · Ketorolac · Lonazolac · Oxametacin · Proglumetacin · Sulindac · Tolmetin · Zomepirac · Oxicams: · Ampiroxicam · Droxicam · Lornoxicam · Meloxicam · Piroxicam · Tenoxicam · Propionic acid derivatives: · Alminoprofen · Benoxaprofen · Dexibuprofen · Dexketoprofen · Fenbufen · Fenoprofen · Flunoxaprofen · Flurbiprofen · Ibuprofen · Ibuproxam · Indoprofen · Ketoprofen · Naproxen · Oxaprozin · Pirprofen · Suprofen · Tiaprofenic acid · Fenamates: · Flufenamic acid · Meclofenamic acid · Mefenamic acid · Tolfenamic acid · Coxibs: · Celecoxib · Etoricoxib · Lumiracoxib · Parecoxib · Rofecoxib · Valdecoxib · other anti-inflammatory and antirheumatic agents, non-steroids: · Nabumetone · Niflumic acid · Azapropazone · Glucosamine · Benzydamine · Glycosaminoglycan · Magnesium salicylate · Proquazone · Superoxide dismutase/Orgotein · Nimesulide · Feprazone · Diacerein · Morniflumate · Tenidap · Oxaceprol · Chondroitin sulfate · Specific antirheumatic agents Quinolines: · Oxycinchophen · Gold preparations: · Sodium aurothiomalate · Sodium aurothiosulfate · Auranofin · Aurothioglucose · Aurotioprol · Penicillamine/Bucillamine v d e Non-steroidal anti-inflammatory drug NSAID products primarily M01A and M02A, also N02BA Salicylates Aspirin acetylsalicylic acid · Aloxiprin · Benorylate · Diflunisal · Ethenzamide · Magnesium salicylate · Methyl salicylate · Salsalate · Salicin · Salicylamide · Sodium salicylate Arylalkanoic acids Diclofenac · Aceclofenac · Acemetacin · Alclofenac · Bromfenac · Etodolac · Indometacin · Indometacin farnesil · Nabumetone · Oxametacin · Proglumetacin · Sulindac · Tolmetin 2-Arylpropionic acids profens Ibuprofen · Alminoprofen · Benoxaprofen · Carprofen · Dexibuprofen · Dexketoprofen · Fenbufen · Fenoprofen · Flunoxaprofen · Flurbiprofen · Ibuproxam · Indoprofen† · Ketoprofen · Ketorolac · Loxoprofen · Miroprofen · Naproxen · Oxaprozin · Pirprofen · Suprofen · Tarenflurbil · Tiaprofenic acid N-Arylanthranilic acids fenamic acids Mefenamic acid · Flufenamic acid · Meclofenamic acid · Tolfenamic acid Pyrazolidine derivatives Phenylbutazone · Ampyrone · Azapropazone · Clofezone · Kebuzone · Metamizole† · Mofebutazone · Oxyphenbutazone · Phenazone · Sulfinpyrazone Oxicams Piroxicam · Droxicam · Lornoxicam · Meloxicam · Tenoxicam · Ampiroxicam COX-2 inhibitors Celecoxib · Deracoxib‡ · Etoricoxib · Firocoxib‡ · Lumiracoxib† · Parecoxib · Rofecoxib† · Valdecoxib† Sulphonanilides Nimesulide Topically used products Bendazac · Diclofenac · Etofenamate · Felbinac · Flurbiprofen · Ibuprofen · Indometacin · Ketoprofen · Naproxen · Piroxicam · Suprofen Others Fluproquazone · COX-inhibiting nitric oxide donator Items listed in bold indicate initially developed compounds of specific groups. †Withdrawn drugs. ‡Veterinary use medications. v d e Topical products for joint and muscular pain M02 Anti-inflammatory preparations, non-steroids Butylpyrazolidines: Phenylbutazone - Mofebutazone - Clofezone - Oxyphenbutazone Acetic acid derivatives: Tolmetin - Diclofenac - Fentiazac other: Benzydamine - Etofenamate - Piroxicam - Felbinac - Bufexamac - Ketoprofen - Bendazac - Naproxen - Ibuprofen - Feprazone - Niflumic acid - Meclofenamic acid - Flurbiprofen - Suxibuzone - Indometacin - Nifenazone Other Tolazoline - Dimethyl sulfoxide Retrieved from http://en..org/wiki/Benzydamine Categories: Non-steroidal anti-inflammatory drugs Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Türkçe Deutsch Polski Português This page was last modified on 25 August 2008, at 17:2
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