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Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
14-September-2008 10:43:22 - Fibrate Clofibrate Clofibrate Gemfibrozil Gemfibrozil Etofibrate Etofibrate Aluminium clofibrate Aluminium clofibrate In pharmacology, the fibrates are a class of amphipathic carboxylic acids. They are used for a range of metabolic disorders, mainly hypercholesterolemia high cholesterol, and are therefore hypolipidemic agents. Contents 1 Members 2 Indications 3 Mechanism 4 Side effects 5 Pharmacology 6 See also 7 References Members Fibrates prescribed commonly are: Bezafibrate e.g. Bezalip Ciprofibrate e.g. Modalim Clofibrate largely obsolete due to side-effect profile, e.g. gallstones Gemfibrozil e.g. Lopid Fenofibrate e.g. TriCor Indications Fibrates are used as accessory therapy in many forms of hypercholesterolemia, usually in combination with statins. Clinical trials do support its use as a monotherapy agent. Although less effective in lowering LDL, fibrates improve HDL and triglyceride levels i.e. increase HDL levels and decrease triglyceride levels, and seem to improve insulin resistance when the dyslipidemia is associated with other features of Syndrome X hypertension and diabetes mellitus type 2. Mechanism Fibrates are agonists of the PPAR-α receptor in muscle, liver, and other tissues. Activation of PPAR-α signaling results in: Increased β-oxidation in the liver Decreased hepatic triglyceride secretion Increased lipoprotein lipase activity, and thus increased VLDL clearance Increased HDL Increased clearance of remnant particles and many more... Side effects Most fibrates can cause mild stomach upset and myopathy muscle pain with CPK elevations. Since fibrates increase the cholesterol content of bile, they increase the risk for gallstones. In combination with statin drugs, fibrates cause an increased risk of rhabdomyolysis idiosyncratic destruction of muscle tissue, leading to renal failure. A powerful statin drug, cerivastatin Lipobay, was withdrawn because of this complication. The less lipophilic statins are less prone to cause this reaction, and are probably safer when combined with fibrates. Pharmacology PPAR PPAR Although used clinically since at least the 1930s1, the mechanism of action of fibrates remained unelucidated until, in the 1990s, it was discovered that fibrates activate PPAR peroxisome proliferator-activated receptors, especially PPARα. The PPARs are a class of intracellular receptors that modulate carbohydrate, fat metabolism and adipose tissue differentiation. Activation of PPARs causes transcription of a number of genes on the DNA that facilitate lipid metabolism. Fibrates are structurally and pharmacologically related to the thiazolidinediones, a novel class of anti-diabetic drugs that also act on PPARs more specifically PPARγ Fibrates are a substrate of metabolized by CYP3A4.1 See also statin v d e Lipid modifying agents C10 Statins HMG-CoA reductase Atorvastatin Cerivastatin‡ Fluvastatin Lovastatin Mevastatin Pitavastatin Pravastatin Rosuvastatin Simvastatin Fibrates PPAR Clofibrate‡ Bezafibrate Aluminium clofibrate Gemfibrozil Fenofibrate Simfibrate Ronifibrate Ciprofibrate Etofibrate Clofibride Clinofibrate Bile acid sequestrants Colestyramine Colestipol Colestilan Colextran Colesevelam Niacin and derivatives Niceritrol Niacin Nicofuranose Aluminium nicotinate Nicotinyl alcohol Acipimox CETP inhibitors Anacetrapib† Torcetrapib§ Combinations Niacin/lovastatin Niacin/simvastatin Ezetimibe/simvastatin Other Dextrothyroxine Probucol Tiadenol Benfluorex Meglutol Omega-3-triglycerides Magnesium pyridoxal 5-phosphate glutamate Policosanol Ezetimibe Lapaquistat§ †Undergoing clinical trials. ‡Withdrawn from market. §Development terminated. References ^ http://www.stacommunications.com/journals/cardiology/2004/June/Pdf/034.pdf Retrieved from http://en..org/wiki/Fibrate Categories: Fibrates Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Deutsch Português Türkçe This page was last modified on 8 September 2008, at 15:26
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So many of us do not eat a balanced diet, get enough sleep, have too much stress, or are impacted with toxins and pollutants. Drinking 2 ounces of MonaVie twice a day will help your body detoxify as well as build your immune system. Its the smartest thing you can do for yourself, so start today. Buying MonaVie through our company guarantees you support 7 days a week and, if you would like to share MonaVie with your family and friends we will guide you from start to finish.
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