Sierra Acai Company
Sierra Acai Company
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Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
14-September-2008 10:43:22 - Gemfibrozil Gemfibrozil Systematic IUPAC name 5-2,5-dimethylphenoxy-2,2-dimethyl-pentanoic acid Identifiers CAS number 25812-30-0 ATC code C10AB04 PubChem 3463 DrugBank APRD00293 Chemical data Formula C15H22O3 Mol. mass 250.333 g/mol Pharmacokinetic data Bioavailability Close to 100% Protein binding 95% Metabolism Hepatic CYP3A4 Half life 1.5 hours Excretion Renal 94% Feces 6% Therapeutic considerations Pregnancy cat. Category C Legal status By Prescription Routes Oral Gemfibrozil is the generic name for an oral drug used to lower lipid levels. It belongs to a group of drugs known as fibrates. It is most commonly sold as the brand name, Lopid. Other brand names include Jezil and Gen-Fibro. Contents 1 Actions 2 Therapeutic effects 3 Nontherapeutic effects and toxicities 4 Indications 5 Contraindications and Precautions 6 Drug Interactions 7 External links Actions Increases activity of Peroxisome proliferator-activated receptor-alpha PPARα, a receptor which is involved in metabolism of carbohydrates and fats, as well as adipose tissue differentiation. This increases synthesis of lipoprotein lipase therefore increasing clearance of triglycerides. Therapeutic effects Reduce triglyceride levels Reduce Very low density lipoprotein VLDL levels Modest reduction of Low density lipoprotein LDL levels Moderate increase in High density lipoprotein HDL levels Nontherapeutic effects and toxicities GI distress Musculoskeletal pain Increased incidence of gallstones Hypokalemia Increased risk of cancer1 Indications Hyperlipidemia Type III: Gemfibrozil is the drug of choice for therapy. Hypertriglyceridemia Type IV: Gemfibrozil, though not as effective as niacin, is better tolerated. Contraindications and Precautions Gemfibrozil should not be given to these patients: Hepatic dysfunction Renal dysfunction Gemfibrozil should be used with caution in these higher risk categories: Biliary tract disease pregnant women obese patients Native Americans Drug Interactions Anticoagulants: Gemfibrozil potentiates the action of coumadin and indanedione anticoagulants. Statin drugs: Concomidant administration of fibrates including gemfibrozil with statin drugs increases the risk of muscle cramping, myopathy, and rhabdomyolysis. External links DrugBank Gemfibrozil NIH Gemfibrozil Drug Info Lopid International Study Safety of Statins - Circulation. 2004;109:III-50 - III-57 v d e Lipid modifying agents C10 Statins HMG-CoA reductase Atorvastatin Cerivastatin‡ Fluvastatin Lovastatin Mevastatin Pitavastatin Pravastatin Rosuvastatin Simvastatin Fibrates PPAR Clofibrate‡ Bezafibrate Aluminium clofibrate Gemfibrozil Fenofibrate Simfibrate Ronifibrate Ciprofibrate Etofibrate Clofibride Clinofibrate Bile acid sequestrants Colestyramine Colestipol Colestilan Colextran Colesevelam Niacin and derivatives Niceritrol Niacin Nicofuranose Aluminium nicotinate Nicotinyl alcohol Acipimox CETP inhibitors Anacetrapib† Torcetrapib§ Combinations Niacin/lovastatin Niacin/simvastatin Ezetimibe/simvastatin Other Dextrothyroxine Probucol Tiadenol Benfluorex Meglutol Omega-3-triglycerides Magnesium pyridoxal 5-phosphate glutamate Policosanol Ezetimibe Lapaquistat§ †Undergoing clinical trials. ‡Withdrawn from market. §Development terminated. Retrieved from http://en..org/wiki/Gemfibrozil Categories: Fibrates Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Italiano Nederlands Português This page was last modified on 12 September 2008, at 01:50
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So many of us do not eat a balanced diet, get enough sleep, have too much stress, or are impacted with toxins and pollutants. Drinking 2 ounces of MonaVie twice a day will help your body detoxify as well as build your immune system. Its the smartest thing you can do for yourself, so start today. Buying MonaVie through our company guarantees you support 7 days a week and, if you would like to share MonaVie with your family and friends we will guide you from start to finish.
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