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News About LDL_apheresis

14-September-2008 10:43:23 - apheresis In medicine, LDL apheresis is a form of apheresis, resembling dialysis, to eliminate the cholesterol-containing particle low-density lipoprotein LDL from the bloodstream. Contents 1 Uses 2 Principles 3 References 4 External links Uses It is used in diseases featuring high LDL, such as the rare homozygous familial hypercholesterolemia, when the heterozygous form does not respond to medical treatment, or when the treatment has led to dangerous side-effects such as rhabdomyolysis. The procedure takes 2-4 hours and must be repeated every several weeks to keep the LDL levels from accumulation and causing cardiovascular disease. It is an expensive procedure, limiting its use to severe cases of hyperlipidemia. Principles LDL apheresis works by leading venous blood through a collumn coated with antibodies to apolipoprotein B the main protein of LDL particles, dextran sulfate or polyacrylate, or by precipitating LDL with heparin at low pH. In all cases apart from polyacrylate absorption, plasma is separated from cells by a cell separator. References Thompson GR. LDL Apheresis. Atherosclerosis 2003;167:1-13. PMID 12618263. Vella A, Pineda AA, O'Brien T. Low-density lipoprotein apheresis for the treatment of refractory hyperlipidemia. Mayo Clin Proc 2001;76:1039-46. PMID 11605688. External links LDL apheresis information on from Cedars-Sinai Medical Centre. LDL apheresis information on from Liposorber. Retrieved from http://en..org/wiki/LDL_apheresis Categories: Medical treatments Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Deutsch This page was last modified on 18 March 2008, at 14:01

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