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14-September-2008 10:43:23 - Lipoprotein Lipoprotein structure chylomicron ApoA, ApoB, ApoC, ApoE apolipoproteins; T triacylglycerol; C cholesterol; green phospholipids Lipoprotein structure chylomicron ApoA, ApoB, ApoC, ApoE apolipoproteins; T triacylglycerol; C cholesterol; green phospholipids A lipoprotein is a biochemical assembly that contains both proteins and lipids. The lipids or their derivatives may be covalently or non-covalently bound to the proteins. Many enzymes, transporters, structural proteins, antigens, adhesins and toxins are lipoproteins. Examples include the high density and low density lipoproteins which enable fats to be carried in the blood stream, the transmembrane proteins of the mitochondrion and the chloroplast, and bacterial lipoproteins 1. Contents 1 Function 2 Classification 2.1 By density 2.2 Alpha and beta 2.3 Lipoproteina 3 Metabolism 3.1 Exogenous pathway 3.2 Endogenous pathway 4 References 5 See also 6 External links Function The lipids are often an essential part of the complex, even if they seem to have no catalytic activity themselves. To isolate transmembrane lipoproteins from their associated membranes, detergents are often needed. All cells use and rely on fats and, for all animal cells, cholesterol as building blocks to create the multiple membranes which cells use to both control internal water content, internal water soluble elements and to organize their internal structure and protein enzymatic systems. Lipoproteins in the blood, an aqueous medium, carry fats around the body. The protein particles have hydrophilic groups aimed outward so as to attract water molecules; this makes them soluble in the salt water based blood pool. Triglyceride-fats and cholesterol are carried internally, shielded from the water by the protein particle. The interaction of the proteins forming the surface of the particles with a enzymes in the blood, b with each other and c with specific proteins on the surfaces of cells determine whether triglycerides and cholesterol will be added to or removed from the lipoprotein transport particles. Regarding atheroma development and progression vs. regression, the key issue has always been cholesterol transport patterns, not cholesterol concentration itself. Classification By density General categories of lipoproteins, listed in order from larger and less dense more fat than protein to smaller and denser more protein, less fat: Chylomicrons - carry triacylglycerol fat from the intestines to the liver, skeletal muscle, and to adipose tissue. Very low density lipoproteins VLDL - carry newly synthesised triacylglycerol from the liver to adipose tissue. Intermediate density lipoproteins IDL - are intermediate between VLDL and LDL. They are not usually detectable in the blood. Low density lipoproteins LDL - carry cholesterol from the liver to cells of the body. Sometimes referred to as the bad cholesterol lipoprotein. High density lipoproteins HDL - collects cholesterol from the body's tissues, and brings it back to the liver. Sometimes referred to as the good cholesterol lipoprotein. Density g/mL Class Diameter nm % protein % cholesterol % phospholipid % triacylglycerol 1.063 HDL 5-15 33 30 29 8 1.019-1.063 LDL 18-28 25 50 21 4 1.006-1.019 IDL 25-50 18 29 22 31 0.95-1.006 VLDL 30-80 10 22 18 50 0.95 Chylomicrons 100-1000 2 8 7 84 1 Alpha and beta It is also possible to classify lipoproteins as alpha and beta, akin to the classification of proteins in serum protein electrophoresis. This terminology is sometimes used in describing lipid disorders such as Abetalipoproteinemia. Lipoproteina Lipoproteina - Lpa, Cardiology diagnostic tests 14 mg/dL : Normal 14-19 mg/dL : ? 19 mg/dL : High risk How to lower: aerobic exercise, niacin, aspirin, guggulipid. 2 Metabolism The handling of lipoproteins in the body is referred to as lipoprotein metabolism. It is divided into two pathways, exogenous and endogenous, depending in large part on whether the lipoproteins in question are composed chiefly of dietary exogenous lipids or whether they originated in the liver endogenous. Exogenous pathway Epithelial cells lining the small intestine readily absorb lipids from the diet. These lipids, including triglycerides, phospholipids, and cholesterol, are assembled with apolipoprotein B-48 into chylomicrons. These nascent chylomicrons are secreted from the intestinal epithelial cells into the lymphatic circulation in a process that depends heavily on apolipoprotein B-48. As they circulate through the lymphatic vessels, nascent chylomicrons bypass the liver circulation and are drained elsewhere into the bloodstream. In the bloodstream, HDL particles donate apolipoprotein C-II and apolipoprotein E to the nascent chylomicron; the chylomicron is now considered mature. Via apolipoprotein C-II, mature chylomicrons activate lipoprotein lipase LPL, an enzyme on endothelial cells lining the blood vessels. LPL catalyzes a hydrolysis reaction that ultimately releases glycerol and fatty acids from the chylomicrons. Glycerol and fatty acids can be absorbed in peripheral tissues, especially adipose and muscle, for energy and storage. The hydrolyzed chylomicrons are now considered chylomicron remnants. The chylomicron remnants continue circulating until they interact via apolipoprotein E with chylomicron remnant receptors, found chiefly in the liver. This interaction causes the endocytosis of the chylomicron remnants, which are subsequently hydrolyzed within lysosomes. Lysosomal hydrolysis releases glycerol and fatty acids into the cell, which can be used for energy or stored for later use. Endogenous pathway The liver is another important source of lipoproteins, principally VLDL. Triacylglycerol and cholesterol are assembled with apolipoprotein B-100 to form VLDL particles. Nascent VLDL particles are released into the bloodstream via a process that depends upon apolipoprotein B-100. As in chylomicron metabolism, the apolipoprotein C-II and apolipoprotein E of VLDL particles are acquired from HDL particles. Once loaded with apolipoproteins C-II and E, the nascent VLDL particle is considered mature. Again like chylomicrons, VLDL particles circulate and encounter LPL expressed on endothelial cells. Apolipoprotein C-II activates LPL, causing hydrolysis of the VLDL particle and the release of glycerol and fatty acids. These products can be absorbed from the blood by preipheral tissues, principally adipose and muscle. The hydrolyzed VLDL particles are now called VLDL remnants or intermediate density lipoproteins IDLs. VLDL remnants can circulate and, via an interaction between apolipoprotein E and the remnant receptor, be absorbed by the liver, or they can be further hydrolyzed by hepatic lipase. Hydrolysis by hepatic lipase releases glycerol and fatty acids, leaving behind IDL remnants, called low density lipoproteins LDL, which contain a relatively high cholesterol content. LDL circulates and is absorbed by the liver and peripheral cells. Binding of LDL to its target tissue occurs through an interaction between the LDL receptor and apolipoprotein B-100 or E on the LDL molecule. Absorption occurs through endocytosis, and the internalized LDL particles are hydrolyzed within lysosomes, releasing lipids, chiefly cholesterol. References ^ Biochemistry 2nd Ed. 1995 Garrett Grisham ^ Beyond Cholesterol, Julius Torelli MD, 2005 ISBN 0-312-34863-0 p.91 See also Apolipoprotein Lipid anchored protein Lipid anchor External links Database of bacterial lipoproteins at mrc-lmb.cam.ac.uk Overview and diagram at washington.edu Lipoprotein assembly at wisc.edu Lipoprotein circulation at purdue.edu MeSH Lipoproteins MeSH Proteolipids v d e Lipids: membrane lipids Lipid bilayer - Phospholipids - Proteolipids - Sphingolipids - Sterols v d e Lipids: lipoprotein metabolism General Chylomicron - HDL - LDL - IDL - VLDL - Lpa Apolipoproteins APOA 1, 2, 5 - APOB - APOC 1, 2, 3, 4 - APOD - APOE - APOH Other Lipoprotein lipase - HDL Cholesterylester transfer protein, Acetyl-CoA C-acyltransferase, LCAT - LDL receptor - Microsomal triglyceride transfer protein - ABCA1 see also disorders Retrieved from http://en..org/wiki/Lipoprotein Categories: Lipids | Lipoproteins Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages العربية Dansk Deutsch Español Français Italiano עברית Lietuvių МакедонÑ?ки 日本語 Polski Português РуÑ?Ñ?кий Suomi Svenska Türkçe УкраїнÑ?ька ä¸æ–‡ This page was last modified on 13 September 2008, at 12:31
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