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14-September-2008 12:50:33 - 418 ABT-418 Systematic IUPAC name 3-methyl-5-2S-1-methylpyrrolidin-2-yl-1,2-oxazole Identifiers CAS number 147402-53-7 ATC code ? PubChem 119380 Chemical data Formula C9H14N2O Mol. mass 166.22 SMILES eMolecules PubChem Pharmacokinetic data Bioavailability ? Metabolism ? Half life ? Excretion ? Therapeutic considerations Pregnancy cat. ? Legal status Routes ? ABT-418 is a drug developed by Abbott, which acts as a partial agonist at neural nicotinic acetylcholine receptors. It binds with high affinity to the α4β2, α2β2 and α7 subtypes, but not to the α3β4 subtype.12 It has nootropic, neuroprotective and anxiolytic effects,3456 and has been researched for treatment of both Alzheimer's disease7 and more recently ADHD.8910 ABT-418 was reasonably effective for both applications and fairly well tolerated, but produced some side effects, principally nausea, and it is unclear whether ABT-418 itself will proceed to clinical development or if another similar drug will be used instead.11 Tablets This pharmacology-related article is a stub. References ^ Papke RL, Thinschmidt JS, Moulton BA, Meyer EM, Poirier A February 1997. Activation and inhibition of rat neuronal nicotinic receptors by ABT-418. Br. J. Pharmacol. 120 3: 429-38. doi:10.1038/sj.bjp.0700930. PMID 9031746. ^ Briggs CA, McKenna DG, Piattoni-Kaplan M June 1995. Human alpha 7 nicotinic acetylcholine receptor responses to novel ligands. Neuropharmacology 34 6: 583-90. doi:10.1016/0028-39089500028-5. PMID 7566493. ^ Arneric SP, Sullivan JP, Briggs CA, Donnelly-Roberts D, Anderson DJ, Raszkiewicz JL, Hughes ML, Cadman ED, Adams P, Garvey DS' July 1994. S-3-methyl-5-1-methyl-2-pyrrolidinyl isoxazole ABT 418: a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterization. J. Pharmacol. Exp. Ther. 270 1: 310-8. PMID 7518514. ^ Decker MW, Brioni JD, Sullivan JP, Buckley MJ, Radek RJ, Raszkiewicz JL, Kang CH, Kim DJ, Giardina WJ, Wasicak JT July 1994. S-3-methyl-5-1-methyl-2-pyrrolidinylisoxazole ABT 418: a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: II. In vivo characterization. J. Pharmacol. Exp. Ther. 270 1: 319-28. PMID 7913497. ^ Brioni JD, O'Neill AB, Kim DJ, Buckley MJ, Decker MW, Arneric SP October 1994. Anxiolytic-like effects of the novel cholinergic channel activator ABT-418. J. Pharmacol. Exp. Ther. 271 1: 353-61. PMID 7965735. ^ Prendergast MA, Terry AV, Jackson WJ, et al April 1997. Improvement in accuracy of delayed recall in aged and non-aged, mature monkeys after intramuscular or transdermal administration of the CNS nicotinic receptor agonist ABT-418. Psychopharmacology Berl. 130 3: 276-84. doi:10.1007/s002130050240. PMID 9151363. ^ Potter A, Corwin J, Lang J, Piasecki M, Lenox R, Newhouse PA March 1999. Acute effects of the selective cholinergic channel activator nicotinic agonist ABT-418 in Alzheimer's disease. Psychopharmacology Berl. 142 4: 334-42. doi:10.1007/s002130050897. PMID 10229057. ^ Wilens TE, Biederman J, Spencer TJ, Bostic J, Prince J, Monuteaux MC, Soriano J, Fine C, Abrams A, Rater M, Polisner D December 1999. A pilot controlled clinical trial of ABT-418, a cholinergic agonist, in the treatment of adults with attention deficit hyperactivity disorder. Am J Psychiatry 156 12: 1931-7. PMID 10588407. ^ Horrigan JP April 2001. Present and future pharmacotherapeutic options for adult attention deficit/hyperactivity disorder. Expert Opin Pharmacother 2 4: 573-86. doi:10.1517/14656566.2.4.573. PMID 11336608. ^ Spencer T, Biederman J 2002. Non-stimulant treatment for Attention-Deficit/Hyperactivity Disorder. J Atten Disord 6 Suppl 1: S109-19. PMID 12685525. ^ Wilens TE, Decker MW October 2007. Neuronal nicotinic receptor agonists for the treatment of attention-deficit/hyperactivity disorder: focus on cognition. Biochem. Pharmacol. 74 8: 1212-23. doi:10.1016/j.bcp.2007.07.002. PMID 17689498. v d e Stimulants Alkylamines Cyclopentamine Geranamine Isometheptene Octodrine Propylhexedrine Tuamine Alphapyrrolidinylalkiophenones α-PPP MDPPP MDPV MPBP MPHP MPPP MOPPP Pyrovalerone Cholinergics ABT-089 ABT-418 Anabasine Arecoline Cotinine Cytisine Dianicline Epibatidine Epiboxidine GTS-21 Ispronicline Nicotine Rivanicline Tebanicline Varenicline Convulsants Bicuculline DMCM Gabazine Pentetrazol Picrotoxin Strychnine Thujone Eugeroics Adrafinil Armodafinil Carphedon Modafinil Phenethylamines 4-Bromomethcathinone 4-Fluoroamphetamine 4-Fluoromethamphetamine 4-Fluoromethcathinone 4-Methylmethcathinone 4-MTA Aletamine Amfepentorex Amphechloral Amphetamine Dextroamphetamine, Adderall Amphetaminil Benzphetamine Bupropion Cathinone Chlorphentermine Clenbuterol Clobenzorex Clortermine Diethylpropion Dimethoxyamphetamine Dimethylamphetamine Dimethylcathinone Ephedrine Epinephrine Ethcathinone Ethylamphetamine Fenethylline Fenfluramine Fenproporex Fludorex Furfenorex Levomethamphetamine Lisdexamfetamine MDMA Mefenorex Methamphetamine Methcathinone Methoxyphedrine Methylone Octopamine Ortetamine Parahydroxyamphetamine PCA PIA PMA PMEA PMMA PPAP Phendimetrazine Phenmetrazine Phentermine Phenylephrine Phenylpropanolamine Propylamphetamine Pseudoephedrine Selegiline Synephrine Tiflorex Xylopropamine Phenylaminooxazoles 4-Methyl-aminorex Aminorex Clominorex Fenozolone Fluminorex Pemoline Thozalinone Piperazines 2C-B-BZP BZP GBR-12783 GBR-12935 GBR-13069 GBR-13098 GBR-13119 MeOPP MBZP Vanoxerine Piperidines 2-Benzylpiperidine Desoxypipradrol Diphemethoxidine Ethylphenidate HDMP-28 --Methyl-1-methyl-4β-2-naphthylpiperidine-3β-carboxylate Methylphenidate Dexmethylphenidate Nocaine Phacetoperane Pipradrol Tropanes 3α-Bis-4-fluorophenylmethoxytropane 3α-4-Chlorophenylphenylmethoxytropane 3-Pseudotropyl-4-fluorobenzoate Altropane IACFT Brasofensine CFT WIN 35,428 β-CIT RTI-55 Cocaethylene Cocaine β-CPPIT Dichloropane RTI-111 Difluoropine FE-β-CPPIT FP-β-CPPIT Ioflupane FPCIT PIT PTT RTI-31 RTI-32 RTI-51 RTI-112 RTI-113 RTI-121 IPCIT RTI-126 RTI-150 RTI-171 RTI-177 RTI-336 Tesofensine Troparil β-CPT, WIN 35,065-2 WF-23 WF-33 WF-60 Xanthines Aminophylline Caffeine Dimethazan Paraxanthine Theobromine Theophylline Others Amineptine Bemegride Benzydamine BPAP Bromantane BTQ Clofenciclan Cypenamine Cyprodenate Diclofensine Dimethocaine Diphenyl prolinol Ethamivan Fencamfamine Feprosidnine Gilutensin GYKI-52895 Hexacyclonate Indanorex Indatraline LR-5182 Mazindol Mesocarb Naphthylisopropylamine Nikethamide Nomifensine Phthalimidopropiophenone Prolintane Sibutramine Yohimbine Zylofuramine See also Sympathomimetic amines Retrieved from http://en..org/wiki/ABT-418 Categories: Pharmacology stubs | Nootropics | Nicotinic agonists | Stimulants | Isoxazoles Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 June 2008, at 08:51
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