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14-September-2008 12:50:34 - ADAM33 ADAM metallopeptidase domain 33 PDB rendering based on 1r54. Available structures: 1r54, 1r55 Identifiers Symbols ADAM33; DJ964F7.1; DKFZp434K0521; FLJ35308; FLJ36751; MGC149823; MGC71889 External IDs OMIM: 607114 MGI: 1341813 HomoloGene: 11881 Gene ontology Molecular function: metalloendopeptidase activity metallopeptidase activity zinc ion binding metal ion binding Cellular component: membrane integral to membrane Biological process: proteolysis integrin-mediated signaling pathway regulation of cytokine biosynthetic process regulation of cell proliferation Orthologs Human Mouse Entrez 80332 110751 Ensembl ENSG00000149451 ENSMUSG00000027318 Uniprot Q9BZ11 Q6TYY9 Refseq NM_025220 mRNA NP_079496 protein NM_033615 mRNA NP_291093 protein Location Chr 20: 3.6 - 3.61 Mb Chr 2: 130.74 - 130.76 Mb Pubmed search 1 2 ADAM metallopeptidase domain 33, also known as ADAM33, is a human gene.1 This gene encodes a member of the ADAM a disintegrin and metalloprotease domain family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing of this gene results in two transcript variants encoding different isoforms.1 References ^ a b Entrez Gene: ADAM33 ADAM metallopeptidase domain 33. Further reading Holgate ST, Davies DE, Rorke S, et al. 2005. ADAM 33 and its association with airway remodeling and hyperresponsiveness in asthma.. Clinical reviews in allergy immunology 27 1: 23-34. PMID 15347848. Holloway JW, Davies DE, Powell R, et al. 2007. The discovery and role of ADAM33, a new candidate gene for asthma.. Expert reviews in molecular medicine 6 17: 1-12. doi:10.1017/S1462399404007963. PMID 15387895. Holgate ST, Yang Y, Haitchi HM, et al. 2006. The genetics of asthma: ADAM33 as an example of a susceptibility gene.. Proceedings of the American Thoracic Society 3 5: 440-3. doi:10.1513/pats.200603-026AW. PMID 16799089. Deloukas P, Matthews LH, Ashurst J, et al. 2002. The DNA sequence and comparative analysis of human chromosome 20.. Nature 414 6866: 865-71. doi:10.1038/414865a. PMID 11780052. Yoshinaka T, Nishii K, Yamada K, et al. 2002. Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity.. Gene 282 1-2: 227-36. PMID 11814695. Van Eerdewegh P, Little RD, Dupuis J, et al. 2002. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness.. Nature 418 6896: 426-30. doi:10.1038/nature00878. PMID 12110844. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Garlisi CG, Zou J, Devito KE, et al. 2003. Human ADAM33: protein maturation and localization.. Biochem. Biophys. Res. Commun. 301 1: 35-43. PMID 12535637. Chae SC, Yoon KH, Chung HT 2003. Identification of novel polymorphisms in the Adam33 gene.. J. Hum. Genet. 48 5: 278-81. doi:10.1007/s10038-003-0019-1. PMID 12768445. Clark HF, Gurney AL, Abaya E, et al. 2003. The secreted protein discovery initiative SPDI, a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.. Genome Res. 13 10: 2265-70. doi:10.1101/gr.1293003. PMID 12975309. Howard TD, Postma DS, Jongepier H, et al. 2003. Association of a disintegrin and metalloprotease 33 ADAM33 gene with asthma in ethnically diverse populations.. J. Allergy Clin. Immunol. 112 4: 717-22. doi:10.1016/S0091. PMID 14564349. Orth P, Reichert P, Wang W, et al. 2004. Crystal structure of the catalytic domain of human ADAM33.. J. Mol. Biol. 335 1: 129-37. PMID 14659745. Zou J, Zhu F, Liu J, et al. 2004. Catalytic activity of human ADAM33.. J. Biol. Chem. 279 11: 9818-30. doi:10.1074/jbc.M309696200. PMID 14676211. Ota T, Suzuki Y, Nishikawa T, et al. 2004. Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat. Genet. 36 1: 40-5. doi:10.1038/ng1285. PMID 14702039. Powell RM, Wicks J, Holloway JW, et al. 2004. The splicing and fate of ADAM33 transcripts in primary human airways fibroblasts.. Am. J. Respir. Cell Mol. Biol. 31 1: 13-21. doi:10.1165/rcmb.2003-0330OC. PMID 14742294. Haitchi HM, Powell RM, Shaw TJ, et al. 2005. ADAM33 expression in asthmatic airways and human embryonic lungs.. Am. J. Respir. Crit. Care Med. 171 9: 958-65. doi:10.1164/rccm.200409-1251OC. PMID 15709049. Zou J, Zhang R, Zhu F, et al. 2005. ADAM33 enzyme properties and substrate specificity.. Biochemistry 44 11: 4247-56. doi:10.1021/bi0476230. PMID 15766253. Simpson A, Maniatis N, Jury F, et al. 2005. Polymorphisms in a disintegrin and metalloprotease 33 ADAM33 predict impaired early-life lung function.. Am. J. Respir. Crit. Care Med. 172 1: 55-60. doi:10.1164/rccm.200412-1708OC. PMID 15805180. This article on a gene on chromosome 20 is a stub. v d e Proteases: metalloendopeptidases EC 3.4.24 ADAM proteins Alpha secretases ADAM9 · ADAM10 · ADAM17 · ADAM19 · ADAM2 · ADAM7 · ADAM8 · ADAM11 · ADAM12 · ADAM15 · ADAM18 · ADAM22 · ADAM23 · ADAM28 · ADAM33 · ADAMTS1 · ADAMTS2 · ADAMTS3 · ADAMTS4 · ADAMTS5 · ADAMTS8 · ADAMTS9 · ADAMTS10 · ADAMTS12 · ADAMTS13 Matrix metalloproteinase Collagenase · Gelatinase Other Neprilysin · Procollagen peptidase · Thermolysin · Pregnancy-associated plasma protein A · Bone morphogenetic protein 1 · Insulysin · Lysostaphin · Insulin degrading enzyme Retrieved from http://en..org/wiki/ADAM33 Categories: Genes on chromosome 20 | Human proteins | Chromosome 20 gene stubs Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 21 July 2008, at 18:28
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