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Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
14-September-2008 12:50:34 - AMPT AMPT Systematic IUPAC name 2-amino-3-4-hydroxyphenyl-2- methylpropanoic acid Identifiers CAS number 658-48-0 ATC code ? PubChem 3125 Chemical data Formula C10H13NO3 Mol. mass 195.21512 g/mol Pharmacokinetic data Bioavailability ? Metabolism ? Half life ? Excretion ? Therapeutic considerations Pregnancy cat. ? Legal status Routes ? Alpha-methyl-p-tyrosine AMPT is a drug that temporarily reduces brain catecholamine activity by competitively inhibiting tyrosine hydroxylase. It has been used in the treatment of pheochromocytoma.1 Contents 1 Side effects 2 Mechanism 3 References 4 External links Side effects AMPT administration leads to a transient exacerbation of depressive symptoms in patients that have responded to catecholaminergic antidepressants. The mood changes induced by AMPT may be mediated by decreases in norepinephrine, while changes in selective attention and motivation may be mediated by dopamine. Prolonged administration can have an impact upon the circadian rhythm.2 Mechanism It prevents the conversion of tyrosine to L-DOPA, the precursor to dopamine. References ^ Ankenman R, Salvatore MF 2007. Low dose alpha-methyl-para-tyrosine AMPT in the treatment of dystonia and dyskinesia. J Neuropsychiatry Clin Neurosci 19 1: 65-9. doi:10.1176/appi.neuropsych.19.1.65. PMID 17308229. ^ Zimmermann RC, Krahn LE, Klee GG, Ditkoff EC, Ory SJ, Sauer MV 2001. Prolonged inhibition of presynaptic catecholamine synthesis with alpha-methyl-para-tyrosine attenuates the circadian rhythm of human TSH secretion. J. Soc. Gynecol. Investig. 8 3: 174-8. PMID 11390253. External links 1 and 2 A Clinical Trial This mental health-related article is a stub. Retrieved from http://en..org/wiki/AMPT Categories: Psychoactive drugs | Mental health stubs Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 10 July 2008, at 04:04
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