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14-September-2008 12:50:27 - chemistry Clinical chemistry also known as clinical biochemistry, chemical pathology or pure blood chemistry is the area of pathology that is generally concerned with analysis of bodily fluids. The discipline originated in the late 19th century with the use of simple chemical tests for various components of blood and urine. Subsequently other techniques were applied including the use and measurement of enzyme activities, spectrophotometry, electrophoresis and immunoassay. Most current laboratories are now highly automated and use assays that are closely monitored and quality controlled. Tests that require examination and measurement of the cells of blood, as well as blood clotting studies, are not included as in the UK these are usually grouped under hematology, but in many countries these specialties along with immunology and microbiology are grouped under laboratory medicine. All biochemical tests come under chemical pathology. These are performed on any kind of body fluid, but mostly on serum or plasma. Serum is the yellow watery part of blood that is left after blood has been allowed to clot and all blood cells have been removed. This is most easily done by centrifugation which packs the denser blood cells and platelets to the bottom of the centrifuge tube, leaving the liquid serum fraction resting above the packed cells. Plasma is essentially the same as serum, but is obtained by centrifuging the blood without clotting. Plasma therefore contains all of the clotting factors, including fibrinogen. A large laboratory will accept samples for up to about 700 different kinds of tests. Even the largest of laboratories rarely does all these tests themselves and some need to be referred to other labs. This large array of tests can be further sub-categorised into sub-specialities of: General or routine chemistry Endocrinology - the study of hormones Immunology - the study of the immune system and antibodies Pharmacology or Toxicology - the study of drugs Chemical pathology tests Common chemical pathology tests include: Sodium; Potassium; Chloride; Bicarbonate; Urea; Creatinine; Calcium; Phosphate; Albumin; Bilirubin; AST; ALT; GGT; Alkaline phosphatase; Magnesium; Osmolality; Urate; Iron; Transferrin; Total protein; Globulins; Glucose; C-reactive protein; HbA1c glycohemoglobin. Blood gases H^+, P_\mathrmCO_2 , P_\mathrmO_2 See also Reference ranges for common blood tests Medical technologist v d e Pathology Principles of pathology Disease - Infection - Ischemia - Inflammation - Wound healing - Neoplasia - Hemodynamics Cell death: Necrosis Liquefactive necrosis, Coagulative necrosis, Caseous necrosis - Apoptosis - Pyknosis - Karyorrhexis - Karyolysis Cellular adaptation: Atrophy - Hypertrophy - Hyperplasia - Dysplasia - Metaplasia Squamous, Glandular accumulations: pigment Hemosiderin, Lipochrome/Lipofuscin, Melanin - Steatosis Anatomical pathology Surgical pathology - Cytopathology - Autopsy - Molecular pathology - Forensic pathology - Dental pathology Gross examination - Histopathology - Immunohistochemistry - Electron microscopy - Immunofluorescence - Fluorescent in situ hybridization Clinical pathology Clinical chemistry - Hematopathology - Transfusion medicine - Medical microbiology - Diagnostic immunology - Immunopathology Enzyme assay - Mass spectrometry - Chromatography - Flow cytometry - Blood bank - Microbiological culture - Serology Retrieved from http://en..org/wiki/Clinical_chemistry Categories: Chemical pathology Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Deutsch Français Italiano Nederlands ‪Norsk bokmål‬ Suomi This page was last modified on 29 August 2008, at 07:07

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