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09-SEPTEMBER-2008 02:07:44 - Gigantism Gigantism Classification and external resources Anna Haining Bates with her parents ICD-10 E22.0, E34.4 ICD-9 253.0 DiseasesDB 30730 MedlinePlus 001174 MeSH D005877 Gigantism or giantism, from Greek gigas, gigantas giant is a condition characterized by excessive growth1 and height significantly above average. Contents 1 Types 2 Terminology 3 See also 4 References 5 External links Types As a medical term, gigantism can refer to: Pituitary gigantism, which is due to prepubertal growth hormone excess. This is sometimes equated with acromegaly, but more precisely, an excess of growth hormone leads to pituitary gigantism vertical growth if the epiphyseal plates have not yet closed,2 but it leads to acromegaly lateral growth if they have closed. Cerebral gigantism, also known as Sotos syndrome,3 which is due to a mutation in NSD1. Terminology There is no precise definition of the degree of height that qualifies a person to be termed a giant. The term has been typically applied to those whose height is not just in the upper 1% of the population but several standard deviations above mean for persons of the same sex, age, and ethnic ancestry. Typical adult heights of Americans of European descent to whom the term might be applied are 2.10 - 2.40 metres 7 - 8 feet. The term is seldom applied to those who are simply tall or above average - whose heights appear to be the healthy result of normal genetics and nutrition. Other names somewhat obsolete for this pathology are hypersomia Greek: hyper over the normal level; soma body and somatomegaly Greek; soma body, object pronoun somatos of the body; megas, megalos great. See also Acromegaly Deep-sea gigantism Growth hormone Island gigantism List of humans with gigantism List of tallest people Local gigantism Megafauna Overgrowth syndrome References ^ Gigantism at Dorland's Medical Dictionary ^ pituitary gigantism at Dorland's Medical Dictionary ^ Sotos syndrome at Dorland's Medical Dictionary January 2008 External links Acromegaly and Gigantism very comprehensive article Acromegaly and Gigantism Image of a patient with macroglossia - enlargement of the tongue Brief overview of overgrowth syndromes in childhoodPDF 2.95 MiB Hoax of Extremely Large Giants Exposed as Untrue v d e Endocrine pathology: endocrine diseases E00-35, 240-259 Pancreas/ glucose metabolism Diabetes mellitus types: type 1, type 2, MODY, complications: coma, angiopathy, ketoacidosis, nephropathy, neuropathy, retinopathy Hypoglycemia - Hyperinsulinism - Zollinger-Ellison syndrome - insulin receptor Rabson-Mendenhall syndrome - Insulin resistance Hypothalamic/ pituitary axes Pituitary Hyperpituitarism Acromegaly, Hyperprolactinaemia, SIADH Hypopituitarism Sheehan's syndrome, Kallmann syndrome, Growth hormone deficiency, Diabetes insipidus Adiposogenital dystrophy - Empty sella syndrome - Pituitary apoplexy - ACTH deficiency Thyroid Hypothyroidism Iodine deficiency, Cretinism, Congenital hypothyroidism, Goitre, Myxedema Hyperthyroidism Graves disease, Toxic multinodular goitre, Teratoma with thyroid tissue or Struma ovarii Thyroiditis De Quervain's thyroiditis, Hashimoto's thyroiditis, Riedel's thyroiditis Euthyroid sick syndrome - Thyroid hormone resistance - Thyroid nodule Parathyroid Hypoparathyroidism Pseudohypoparathyroidism - Hyperparathyroidism Primary, Secondary, Tertiary Adrenal Adrenocortical hyperfunction: Cushing's syndrome Nelson's syndrome, Pseudo-Cushing's syndrome - Hyperaldosteronism Conn syndrome, Bartter syndrome CAH Lipoid, 3β, 11β, 17α, 21α Adrenal insufficiency Addison's disease, Waterhouse-Friderichsen syndrome - Hypoaldosteronism Gonads ovarian Polycystic ovary syndrome, Premature ovarian failure testicular 5-alpha-reductase deficiency, 17-beta-hydroxysteroid dehydrogenase deficiency general Hypogonadism, Delayed puberty, Precocious puberty Other Androgen insensitivity syndrome - Autoimmune polyendocrine syndrome - Carcinoid syndrome - Gigantism - Short stature Laron syndrome, Psychogenic dwarfism - Multiple endocrine neoplasia 1, 2 - Progeria - Woodhouse-Sakati syndrome - thymus Abscess of thymus, Thymus hyperplasia see also congenital, neoplasia Retrieved from http://en..org/wiki/Gigantism Categories: Growth disorders | Human height | Growth hormones | Neuroendocrinology | People with gigantismHidden category: Articles needing additional references from January 2008 Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Deutsch Eesti Ελληνικά Español Euskara Français Bahasa Indonesia Italiano עברית 日本語 Polski Português РуÑ?Ñ?кий Suomi Svenska This page was last modified on 20 August 2008, at 11:42
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