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09-SEPTEMBER-2008 02:07:44 - metabolism Redirected from Glucose metabolism disorder Jump to: navigation, search Carbohydrate metabolism denotes the various biochemical processes responsible for the formation, breakdown and interconversion of carbohydrates in living organisms. The most important carbohydrate is glucose, a simple sugar monosaccharide that is metabolized by nearly all known organisms. Glucose and other carbohydrates are part of a wide variety of metabolic pathways across species: plants synthesize carbohydrates from atmospheric gases by photosynthesis storing the absorbed energy internally, often in the form of starch or lipids. Plant components are eaten by animals and fungi, and used as fuel for cellular respiration. Oxidation of one gram of carbohydrate yields approximately 4 kcal of energy and from lipids about 9 kcal. Energy obtained from metabolism is usually stored temporarily within cells in the form of ATP. Organisms capable of aerobic respiration metabolize glucose and oxygen to release energy with carbon dioxide and water as byproducts. Carbohydrates are a superior short-term fuel for organisms because they are simpler to metabolize than fats or proteins. In animals, the most important carbohydrate is glucose; so much so, that the level of glucose is used as the main control for the central metabolic hormone, insulin. Starch, and cellulose in a few animals eg, termites, ruminants, and some bacteria, being both glucose polymers are disassembled during digestion and absorbed as glucose. Other simple carbohydrates have their own enzymatic oxidation pathways, as do some of the more complex carbohydrates. The disaccharide lactose, for instance, requires the enzyme lactase to be broken into into its monosaccharides components; many animals lack this enzyme in adulthood. Carbohydrates are typically stored as long polymers of glucose molecules with Glycosidic bonds for structural support e.g. chitin, cellulose or for energy storage e.g. glycogen, starch. However, the strong affinity of most carbohydrates for water makes storage of large quantities of carbohydrates inefficient due to the large molecular weight of the solvated water-carbohydrate complex. In some organisms, such as plants, excess carbohydrates are sometimes catabolised to form Acetyl-CoA, which is a feed stock for the fatty acid synthesis pathway; fatty acids, triglycerides, and other lipids are commonly used for long-term energy storage. The hydrophobic character of lipids makes them a much more compact form of energy storage than hydrophilic carbohydrates. However, animals, including humans, lack the necessary enzymatic machinery and so do not synthesize lipids from carbohydrate. All carbohydrates share a general formula of approximately CnH2nOn; glucose is C6H12O6. Monosaccharides may be chemically bonded together to form disaccharides such as sucrose and longer polysaccharides such as starch and cellulose. Contents 1 Catabolism 2 Metabolic pathways 3 Glucoregulation 4 Human diseases of carbohydrate metabolism 5 External links Catabolism Main article: Carbohydrate catabolism Oligo/polysaccharides are typically cleaved into smaller monosaccharides by enzymes called Glycoside hydrolases. The monosaccharide units then enter monosaccharide catabolism. Organisms vary in the range of monosaccharides they can absorb and use, and also in the range of more complex carbohydrates they are capable of disassembling. Metabolic pathways Carbon fixation, or photosynthesis, in which CO2 is reduced to carbohydrate. Glycolysis - the oxidation metabolism of glucose molecules to obtain ATP and Pyruvate Pyruvate from glycolysis enters the Krebs cycle in aerobic organisms. The Pentose phosphate pathway, which acts in the conversion of hexoses into pentoses and in NADPH regeneration. Glycogenesis - the conversion of excess glucose into glycogen as a cellular storage mechanism; this prevents excessive osmotic pressure buildup inside the cell Glycogenolysis - the breakdown of glycogen into glucose, which provides a glucose supply for glucose-dependent tissues. Gluconeogenesis - de novo synthesis of glucose molecules from simple organic compounds. an example in humans is the conversion of a few amino acids in cellular protein to glucose. Glucoregulation Glucoregulation is the maintenance of steady levels of glucose in the body; it is part of homeostasis, and keeps a constant internal environment around cells in the body. The hormone insulin is the primary regulatory signal in animals, suggesting that the basic mechanism is very old and very central to animal life. When present, it causes many tissue cells to take up glucose from the circulation, causes some cells to store glucose internally in the form of glycogen, causes some cells to take in and hold lipids, and in many cases controls cellular electrolyte balances and amino acid uptake as well. Its absence turns off glucose uptake into cells, reverses electrolyte adjustments, begins glycogen breakdown and glucose release into the circulation by some cells, begins lipid release from lipid storage cells, etc. Circulatory glucose levels are the most important signal to the insulin producing cells, and as they are largely due to dietary carbohydrate intake, diet controls major aspects of metabolism via insulin. In humans, insulin is made by beta cells in the pancreas, fat is stored in adipose tissue cells, and glycogen is both stored and released as needed by liver cells. No glucose is released to the blood from internal glycogen stores from muscle cells, however, regardless of insulin levels. The hormone glucagon, on the other hand, acts in the opposite direction to insulin, forcing the conversion of glycogen in some cells to glucose. It's release is controlled by low levels of blood glucose. Human diseases of carbohydrate metabolism Diabetes mellitus Lactose intolerance Fructose intolerance Galactosemia Glycogen storage disease External links MeSH Carbohydrate+metabolism Glucose Metabolism and Diabetes BBC - GCSE Bitesize - Biology | Humans | Glucoregulation v d e Metabolism: carbohydrate metabolism Anabolism Gluconeogenesis - Glycogenesis - Photosynthesis Carbon fixation Carbohydrate catabolism Glycolysis - Glycogenolysis - Fermentation Ethanol, Lactic acid - Cellular respiration - Xylose metabolism Other Pentose phosphate pathway v d e Metabolism: carbohydrate metabolism - glycogenesis and glycogenolysis enzymes Glycogenesis Phosphoglucomutase - UDP-glucose pyrophosphorylase - Glycogen synthase Glycogen branching enzyme Glycogenolysis Glycogen phosphorylase Debranching enzyme - Phosphoglucomutase - Glycogenin Maltase Regulation Phosphorylase kinase - Phosphoprotein phosphatase v d e Metabolism: carbohydrate metabolism: glycolysis/gluconeogenesis enzymes Glycolysis Glucokinase/Hexokinase/Glucose 6-phosphatase - Glucose isomerase - Phosphofructokinase 1/Fructose 1,6-bisphosphatase Aldolase - Triosephosphate isomerase Glyceraldehyde 3-phosphate dehydrogenase - Phosphoglycerate kinase - Phosphoglycerate mutase - Enolase - Pyruvate kinase Gluconeogenesis only to oxaloacetate: Pyruvate carboxylase - Phosphoenolpyruvate carboxykinase from lactate Cori cycle: Lactate dehydrogenase from alanine Alanine cycle: Alanine transaminase from glycerol: Glycerol kinase - Glycerol dehydrogenase Regulatory Phosphofructokinase 2/Fructose 2,6-bisphosphatase - Bisphosphoglycerate mutase see also disorders v d e Metabolism: carbohydrate metabolism - fructose and galactose enzymes Fructose Hepatic fructokinase - Aldolase B Sorbitol Sorbitol dehydrogenase - Aldose reductase Galactose Galactokinase - Galactose-1-phosphate uridylyltransferase - UDP galactose epimerase Aldose reductase Lactose Lactose synthase - Lactase see also disorders v d e Metabolism: carbohydrate metabolism - glycosaminoglycan enzymes Anabolism L-xylulose reductase - L-gulonolactone oxidase - UDP-glucuronate 5'-epimerase - Xylosyltransferase - Sulfotransferase Catabolism: Hunter, Hurler Iduronate-2-sulfatase - Iduronidase Catabolism: Sanfilippo, Sly Heparan sulfamidase - N-acetyltransferase - Alpha-N-acetylglucosaminidase - Glucuronidase - N-acetylglucosamine-6-sulfatase Catabolism: Morquio/Maroteaux-Lamy Arylsulfatase B - Galactosamine-6 sulfatase - Beta-galactosidase v d e Metabolism: carbohydrate metabolism - glycoprotein enzymes Anabolism Dolichol kinase Catabolism Neuraminidase - Beta-galactosidase - Hexosaminidase - mannosidase alpha-Mannosidase, beta-Mannosidase - Aspartylglucosaminidase - Fucosidase - NAGA Transport SLC17A5 M6P tagging N-acetylglucosamine-1-phosphate transferase see also disorders Retrieved from http://en..org/wiki/Carbohydrate_metabolism Categories: Metabolism Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Deutsch Français 日本語 ไทย This page was last modified on 26 August 2008, at 06:56
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