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Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
11-SEPTEMBER-2008 13:54:10 - CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 Identifiers Symbol CYP51A1 Alt. Symbols CYP51 Entrez 1595 HUGO 2649 OMIM 601637 RefSeq NM_000786 UniProt Q16850 Other data EC number 1.14.13.70 Locus Chr. 7 q21.2-21.3 CYP51A1 or lanosterol 14 alpha-demethylase is a cytochrome P450 family 51, subfamily A, polypeptide 1 which converts lanosterol to cholesterol. It is a target for antifungal drugs, inhibiting the production of ergosterol. Over-expression of CYP51A1 can lead to resistance to these antifungals.1 Lanosterol Ergosterol Cholesterol See also Antifungal drug References ^ Vanden Bossche H, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D 1998. Antifungal drug resistance in pathogenic fungi. Med. Mycol. 36 Suppl 1: 119-28. PMID 9988500. External links MeSH cytochrome+P-450+CYP51 This oxidoreductase article is a stub. v d e Metabolism: lipid metabolism - ketones/mevalonate pathway/cholesterol synthesis enzymes To HMG-CoA Acetyl-Coenzyme A acetyltransferase - HMG-CoA synthase regulated step Ketogenesis HMG-CoA lyase - 3-hydroxybutyrate dehydrogenase - Thiophorase To Mevalonic acid HMG-CoA reductase To DMAPP Mevalonate kinase - Phosphomevalonate kinase - Pyrophosphomevalonate decarboxylase - Isopentenyl-diphosphate delta isomerase To Cholesterols Dimethylallyltranstransferase - Geranyl pyrophosphate - Farnesyl-diphosphate farnesyltransferase - Squalene monooxygenase - Lanosterol synthase - CYP51A1 To Bile acids Cholesterol 7 alpha-hydroxylase see also intermediates v d e Oxidoreductases: dioxygenases, including steroid hydroxylases EC 1.14 1.14.11 - 2-oxoglutarate Prolyl hydroxylase - Lysyl hydroxylase 1.14.13 - NADH or NADPH Flavin-containing monooxygenase - Nitric oxide synthase NOS1, NOS2A, NOS3 - Cholesterol 7 alpha-hydroxylase - Methane monooxygenase - 3A4 -51A1 1.14.14 - reduced flavin or flavoprotein 19A1 - 2D6 - 2E1 1.14.15 - reduced iron-sulfur protein 11B1 - 11B2 - 11A1 1.14.16 - reduced pteridine Phenylalanine hydroxylase - Tyrosine hydroxylase - Tryptophan hydroxylase 1.14.17 - reduced ascorbate Dopamine beta hydroxylase 1.14.18-19 - other Tyrosinase - Stearoyl-CoA desaturase-1 1.14.99 - miscellaneous Cyclooxygenase - Heme oxygenase HMOX1 - Squalene monooxygenase - 17A1 - 21A2 v d e Cytochromes, oxygenases: cytochrome P450 EC 1.14 CYP1 A1, A2, B1 CYP2 A6, A7, A13, B6, C8, C9, C18, C19, D6, E1, F1, J2, R1, S1, U1, W1 CYP3 CYP3A A4, A5, A7, A43 CYP4 A11, A22, B1, F2, F3, F8, F11, F12, F22, V2, X1, Z1 CYP5-20 CYP5 A1 - CYP7 A1, B1 - CYP8 A1, B1 - CYP11 A1, B1, B2 - CYP17 A1 - CYP19 A1 - CYP20 A1 CYP21-51 CYP21 A2 - CYP24 A1 - CYP26 A1, B1, C1 - CYP27 A1, B1, C1 - CYP39 A1 - CYP46 A1 - CYP51 A1 Retrieved from http://en..org/wiki/CYP51A1 Categories: Genes on chromosome 7 | Oxidoreductase stubs | Cytochrome P450Hidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 9 July 2008, at 18:07
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