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11-SEPTEMBER-2008 12:20:15 - Fen-phen July 2008 Fen-phen was an anti-obesity medication an anorectic which consisted of two drugs: fenfluramine and phentermine. Fenfluramine, and later, a related drug, dexfenfluramine, was marketed by American Home Products, now known as Wyeth. After reports of valvular heart disease and pulmonary hypertension, primarily in women who had been undergoing treatment with Fen-phen, the Food and Drug Administration FDA requested its withdrawal from the market in September 1997. The action was based on findings from doctors who had evaluated patients taking these two drugs with echocardiograms, a procedure that can test the functioning of heart valves. The findings indicated that approximately 30 percent of evaluated patients had abnormal echocardiograms, even though they had no symptoms. This percentage of abnormal test results was much higher than would be expected from a comparatively-sized sample of the population who had not been exposed to either fenfluramine or dexfenfluramine.citation needed In July 1997, researchers at the Mayo Clinic and Mayo Foundation reported 24 cases of rare valvular disease in women who took the Fen-phen combination therapy.citation needed The FDA alerted medical doctors that it had received nine additional reports of the same type, and requested all health care professionals to report any such cases to the agency's MedWatch program, or to their respective pharmaceutical manufacturers. The FDA subsequently received 66 additional reports of heart valve disease, all primarily associated with Fen-phen.citation needed There were also reports of documented heart-valve problems in patients taking only either fenfluramine or dexfenfluramine.citation needed The FDA requested that the manufacturers of fenfluramine and dexfenfluramine stress the potential risk to the heart in the drugs' labeling and in patient package inserts. As of 1997, the FDA was continuing to receive reports of cardiac valvular disease in persons who had taken these drugs. This valvular disease typically involves the aortic and mitral valves. As of 2004, Fen-phen is no longer widely available. In April 2005, American Lawyer magazine ran a cover story on the Fen-phen mass tort crisis, reporting that more than 50,000 product liability lawsuits had been filed by alleged Fen-phen victims. Estimates of total liability run as high as $14 billion. In 2008, three Kentucky attorneys stood trial in a U.S. federal district court for allegedly bilking millions of dollars appropriated to their clients in a Fen-phen settlement. One attorney, Melbourne Mills, Jr., was acquitted. Jurors were deadlocked on the other two attorneys, Shirley Cunningham Jr. and William Gallion. A judge declared a mistrial in the case.1 Also in 2008, 60 Minutes ran a broadcast about two Kentucky residents suing Wyeth because Fen-phen had done permanent damage to their hearts.citation needed References ^ 1 External links U.S. FDA Fen-Phen information Retrieved from http://en..org/wiki/Fen-phen Categories: Anorectics | Withdrawn drugsHidden categories: Articles needing additional references from July 2008 | All articles with statements | Articles with statements since July 2008 Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Srpskohrvatski / СрпÑ?кохрватÑ?ки This page was last modified on 20 July 2008, at 00:28
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