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11-SEPTEMBER-2008 12:20:15 - Leptin receptor Leptin receptor Identifiers Symbols LEPR; CD295; OBR External IDs OMIM: 601007 MGI: 104993 HomoloGene: 1731 Gene ontology Molecular function: hematopoietin/interferon-class D200-domain cytokine receptor activity protein binding Cellular component: integral to plasma membrane membrane Biological process: energy reserve metabolic process cell surface receptor linked signal transduction multicellular organismal development Orthologs Human Mouse Entrez 3953 16847 Ensembl n/a ENSMUSG00000057722 Uniprot n/a P48356 Refseq NM_001003679 mRNA NP_001003679 protein NM_010704 mRNA NP_034834 protein Location n/a Chr 4: 101.22 - 101.31 Mb Pubmed search 1 2 Leptin receptor, also known as LEPR, is a human gene. LEPR has also been designated as CD295 cluster of differentiation 295. Leptin LEP; MIM 164160, an adipocyte-specific hormone that regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure, acts through the leptin receptor LEPR, a single-transmembrane-domain receptor of the cytokine receptor family.supplied by OMIM1 References ^ Entrez Gene: LEPR leptin receptor. Further reading Heshka JT, Jones PJ 2001. A role for dietary fat in leptin receptor, OB-Rb, function.. Life Sci. 69 9: 987-1003. PMID 11508653. Tartaglia LA, Dembski M, Weng X, et al. 1996. Identification and expression cloning of a leptin receptor, OB-R.. Cell 83 7: 1263-71. PMID 8548812. Chen H, Charlat O, Tartaglia LA, et al. 1996. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice.. Cell 84 3: 491-5. PMID 8608603. Cioffi JA, Shafer AW, Zupancic TJ, et al. 1996. Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction.. Nat. Med. 2 5: 585-9. PMID 8616721. Considine RV, Considine EL, Williams CJ, et al. 1996. The hypothalamic leptin receptor in humans: identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations.. Diabetes 45 7: 992-4. PMID 8666155. Chung WK, Power-Kehoe L, Chua M, Leibel RL 1996. Mapping of the OB receptor to 1p in a region of nonconserved gene order from mouse and rat to human.. Genome Res. 6 5: 431-8. PMID 8743992. Bennett BD, Solar GP, Yuan JQ, et al. 1997. A role for leptin and its cognate receptor in hematopoiesis.. Curr. Biol. 6 9: 1170-80. PMID 8805376. Winick JD, Stoffel M, Friedman JM 1997. Identification of microsatellite markers linked to the human leptin receptor gene on chromosome 1.. Genomics 36 1: 221-2. doi:10.1006/geno.1996.0455. PMID 8812446. Luoh SM, Di Marco F, Levin N, et al. 1997. Cloning and characterization of a human leptin receptor using a biologically active leptin immunoadhesin.. J. Mol. Endocrinol. 18 1: 77-85. PMID 9061609. Echwald SM, Sørensen TD, Sørensen TI, et al. 1997. Amino acid variants in the human leptin receptor: lack of association to juvenile onset obesity.. Biochem. Biophys. Res. Commun. 233 1: 248-52. doi:10.1006/bbrc.1997.6430. PMID 9144432. Thompson DB, Ravussin E, Bennett PH, Bogardus C 1997. Structure and sequence variation at the human leptin receptor gene in lean and obese Pima Indians.. Hum. Mol. Genet. 6 5: 675-9. PMID 9158141. Gotoda T, Manning BS, Goldstone AP, et al. 1997. Leptin receptor gene variation and obesity: lack of association in a white British male population.. Hum. Mol. Genet. 6 6: 869-76. PMID 9175732. Bailleul B, Akerblom I, Strosberg AD 1997. The leptin receptor promoter controls expression of a second distinct protein.. Nucleic Acids Res. 25 14: 2752-8. PMID 9207021. Chung WK, Power-Kehoe L, Chua M, et al. 1997. Exonic and intronic sequence variation in the human leptin receptor gene LEPR.. Diabetes 46 9: 1509-11. PMID 9287054. Bjørbaek C, Uotani S, da Silva B, Flier JS 1998. Divergent signaling capacities of the long and short isoforms of the leptin receptor.. J. Biol. Chem. 272 51: 32686-95. PMID 9405487. Clément K, Vaisse C, Lahlou N, et al. 1998. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction.. Nature 392 6674: 398-401. doi:10.1038/32911. PMID 9537324. Carpenter LR, Farruggella TJ, Symes A, et al. 1998. Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor.. Proc. Natl. Acad. Sci. U.S.A. 95 11: 6061-6. PMID 9600917. Kielar D, Clark JS, Ciechanowicz A, et al. 1998. Leptin receptor isoforms expressed in human adipose tissue.. Metab. Clin. Exp. 47 7: 844-7. PMID 9667233. Haniu M, Arakawa T, Bures EJ, et al. 1998. Human leptin receptor. Determination of disulfide structure and N-glycosylation sites of the extracellular domain.. J. Biol. Chem. 273 44: 28691-9. PMID 9786864. Haft CR, de la Luz Sierra M, Barr VA, et al. 1998. Identification of a family of sorting nexin molecules and characterization of their association with receptors.. Mol. Cell. Biol. 18 12: 7278-87. PMID 9819414. External links MeSH LEPR+protein,+human This membrane protein-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Proteins: clusters of differentiation see also list of human clusters of differentiation 1-50 CD1 a-c, 1A, 1D, 1E - CD2 - CD3 γ, δ, ε - CD4 - CD5 - CD6 - CD7 - CD8 a - CD9 - CD10 - CD11 a, b, c - CD13 - CD14 - CD15 - CD16 A, B - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 A, B - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 a, b, c, d - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 a, b, c, d, e, f - CD50 51-100 CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 E, L, P - CD63 - CD64 - CD66 a, b, c, d, e, f - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD79 a, b - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 a, d, e, h, j, k - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100 101-150 CD101 - CD102 - CD103 - CD104 - CD105 - CD106 - CD107 a, b - CD108 - CD109 - CD110 - CD111 - CD112 - CD113 - CD114 - CD115 - CD116 - CD117 - CD118 - CD119 - CD120 a, b - CD121 a, b - CD122 - CD123 - CD124 - CD125 - CD126 - CD127 - CD129 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD136 - CD137 - CD138 - CD140b - CD141 - CD142 - CD143 - CD144 - CD146 - CD147 - CD148 - CD150 151-200 CD151 - CD152 - CD153 - CD154 - CD155 - CD156 a, b, c - CD157 - CD158 a, d, e, i, k - CD159 a, c - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 a, b - CD168 - CD169 - CD170 - CD171 - CD172 a, b, g - CD174 - CD177 - CD178 - CD179 a, b - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200 201-250 CD201 - CD202b - CD204 - CD205 - CD206 - CD207 - CD208 - CD209 - CDw210 a, b - CD212 - CD213a 1, 2 - CD217 - CD218 a, b - CD220 - CD221 - CD222 - CD223 - CD224 - CD225 - CD226 - CD227 - CD228 - CD229 - CD230 - CD233 - CD234 - CD235 a, b - CD236 - CD238 - CD239 - CD240CE - CD241 - CD243 - CD244 - CD246 - CD247- CD248 - CD249 251-300 CD252 - CD253 - CD254 - CD256 - CD257 - CD258 - CD261 - CD262 - CD264 - CD265 - CD266 - CD267 - CD268 - CD269 - CD271 - CD272 - CD273 - CD274 - CD275 - CD276 - CD278 - CD279 - CD280 - CD281 - CD282 - CD283 - CD284 - CD286 - CD288 - CD289 - CD290 - CD292 - CDw293 - CD294 - CD295 - CD297 - CD298 - CD299 301-350 CD300A - CD304 - CD305 - CD307 - CD309 - CD312 - CD314 - CD315 - CD316 - CD317 - CD318 - CD320 - CD321 - CD322 - CD324 - CD325 - CD326 - CD328 - CD329 - CD331 - CD332 - CD333 - CD334 - CD335 - CD336 - CD337 - CD338 - CD339 - CD340 - CD344 - CD349 - CD350 Retrieved from http://en..org/wiki/Leptin_receptor Categories: Human proteins | Membrane protein stubs | Clusters of differentiationHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 10:51
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