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11-SEPTEMBER-2008 12:20:15 - Peptide YY Redirected from PYY 3-36 Peptide YY PDB rendering based on 1qbf. Available structures: 1qbf, 1ru5, 1ruu, 2dez, 2df0 Identifiers Symbols PYY; PYY1 External IDs OMIM: 600781 MGI: 99924 HomoloGene: 3066 Gene ontology Molecular function: hormone activity Cellular component: extracellular region soluble fraction Biological process: cell motility cytoskeleton organization and biogenesis G-protein coupled receptor protein signaling pathway cell-cell signaling digestion feeding behavior cell proliferation Orthologs Human Mouse Entrez 5697 217212 Ensembl ENSG00000131096 ENSMUSG00000017311 Uniprot P10082 Q3V334 Refseq NM_004160 mRNA NP_004151 protein NM_145435 mRNA NP_663410 protein Location Chr 17: 39.39 - 39.44 Mb Chr 11: 101.92 - 101.92 Mb Pubmed search 1 2 Peptide YY is a short 36 amino acid protein released by cells in the ileum and colon in response to feeding. In humans it appears to reduce appetite. It is also known as PYY, Peptide Tyrosine Tyrosine, or Pancreatic Peptide YY3-361. Contents 1 Description 2 Relevance to obesity 3 References 4 Further reading 5 See also 6 External links Description Peptide YY3-36 PYY is a linear polypeptide consisting of 36 amino acids with structural homology to NPY and pancreatic polypeptide. PYY exerts its action through NPY receptors, inhibits gastric motility and increases water and electrolyte absorption in the colon.2 PYY may also suppress pancreatic secretion. It is secreted by the neuroendocrine cells in the ileum and colon in response to a meal, and has been shown to reduce appetite. Research has also indicated that PYY may be useful in removing aluminium aluminum accumulated in the brain. Relevance to obesity Leptin also reduces appetite in response to feeding, but obese people develop a resistance to leptin. In contrast, obese people secrete less PYY than normal people do, and in response to added PYY, they reduce their food intake.3 References ^ Entrez Gene: PYY peptide YY. ^ Liu C, Aloia T, Adrian T, Newton T, Bilchik A, Zinner M, Ashley S, McFadden D 1996. Peptide YY: a potential proabsorptive hormone for the treatment of malabsorptive disorders.. Am Surg 62 3: 232-6. PMID 8607584. ^ Batterham RL et al September 4, 2003. Inhibition of food intake in obese subjects by peptide YY3-36. New England Journal of Medicine 349 10: 926-928. Massachusetts Medical Society. PMID 12954742. Retrieved on 2006-01-19. Further reading Ekblad E, Sundler F 2002. Distribution of pancreatic polypeptide and peptide YY.. Peptides 23 2: 251-61. PMID 11825640. Sandström O, El-Salhy M 2002. Ontogeny and the effect of aging on pancreatic polypeptide and peptide YY.. Peptides 23 2: 263-7. PMID 11825641. Yang H 2002. Central and peripheral regulation of gastric acid secretion by peptide YY.. Peptides 23 2: 349-58. PMID 11825649. Naruse S, Kitagawa M, Ishiguro H, Hayakawa T 2002. Feedback regulation of pancreatic secretion by peptide YY.. Peptides 23 2: 359-65. PMID 11825650. Aponte GW 2002. PYY-mediated fatty acid induced intestinal differentiation.. Peptides 23 2: 367-76. PMID 11825651. Hagan MM 2002. Peptide YY: a key mediator of orexigenic behavior.. Peptides 23 2: 377-82. PMID 11825652. Mannon PJ 2002. Peptide YY as a growth factor for intestinal epithelium.. Peptides 23 2: 383-8. PMID 11825653. Tseng WW, Liu CD 2002. Peptide YY and cancer: current findings and potential clinical applications.. Peptides 23 2: 389-95. PMID 11825654. El-Salhy M, Suhr O, Danielsson A 2002. Peptide YY in gastrointestinal disorders.. Peptides 23 2: 397-402. PMID 11825655. Imamura M 2002. Effects of surgical manipulation of the intestine on peptide YY and its physiology.. Peptides 23 2: 403-7. PMID 11825656. Beglinger C, Degen L 2007. Gastrointestinal satiety signals in humans--physiologic roles for GLP-1 and PYY?. Physiol. Behav. 89 4: 460-4. doi:10.1016/j.physbeh.2006.05.048. PMID 16828127. Eberlein GA, Eysselein VE, Schaeffer M, et al. 1989. A new molecular form of PYY: structural characterization of human PYY3-36 and PYY1-36.. Peptides 10 4: 797-803. PMID 2587421. Facer P, Bishop AE, Cole GA, et al. 1989. Developmental profile of chromogranin, hormonal peptides, and 5-hydroxytryptamine in gastrointestinal endocrine cells.. Gastroenterology 97 1: 48-57. PMID 2721879. Tatemoto K, Nakano I, Makk G, et al. 1989. Isolation and primary structure of human peptide YY.. Biochem. Biophys. Res. Commun. 157 2: 713-7. PMID 3202875. Lukinius AI, Ericsson JL, Lundqvist MK, Wilander EM 1986. Ultrastructural localization of serotonin and polypeptide YY PYY in endocrine cells of the human rectum.. J. Histochem. Cytochem. 34 6: 719-26. PMID 3517149. Adrian TE, Ferri GL, Bacarese-Hamilton AJ, et al. 1985. Human distribution and release of a putative new gut hormone, peptide YY.. Gastroenterology 89 5: 1070-7. PMID 3840109. Lundell I, Blomqvist AG, Berglund MM, et al. 1996. Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.. J. Biol. Chem. 270 49: 29123-8. PMID 7493937. Bard JA, Walker MW, Branchek TA, Weinshank RL 1995. Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.. J. Biol. Chem. 270 45: 26762-5. PMID 7592911. Hort Y, Baker E, Sutherland GR, et al. 1995. Gene duplication of the human peptide YY gene PYY generated the pancreatic polypeptide gene PPY on chromosome 17q21.1.. Genomics 26 1: 77-83. PMID 7782089. Kohri K, Nata K, Yonekura H, et al. 1993. Cloning and structural determination of human peptide YY cDNA and gene.. Biochim. Biophys. Acta 1173 3: 345-9. PMID 8318545. See also Ghrelin Leptin External links MeSH Peptide+YY This article on a gene on chromosome 17 is a stub. v d e Hormones: gastrointestinal hormones CCK - EGF - GIP - Gastrin releasing peptide - Gastrins - Proglucagon - Motilin - Peptide YY -Prokineticin - Secretin - VIP Retrieved from http://en..org/wiki/Peptide_YY Categories: Genes on chromosome 17 | Human proteins | Chromosome 17 gene stubs | Peptide hormones | Nutrition | Obesity Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Nederlands This page was last modified on 25 August 2008, at 19:07
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