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News About Alitretinoin

14-September-2008 18:38:38 - Alitretinoin Alitretinoin Systematic IUPAC name 2E,4E,6Z,8E-3,7-dimethyl-9-2,6,6-trimethyl- 1-cyclohexenylnona-2,4,6,8-tetraenoic acid Identifiers CAS number 5300-03-8 ATC code L01XX22 D11AX191 PubChem 449171 DrugBank APRD00017 Chemical data Formula C20H28O2 Mol. mass 300.435 g/mol Pharmacokinetic data Bioavailability ? Metabolism ? Half life ? Excretion ? Therapeutic considerations Pregnancy cat. ? Legal status Rx only Routes Topical Alitretinoin tradename Panretin is an antineoplastic agent developed by Ligand Pharmaceuticals. It is a first generation retinoid. Contents 1 Clinical uses 2 History 3 References 4 External links Clinical uses Alitretinoin is indicated for the topical treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma. It is not indicated when systemic anti-KS therapy is required e.g., more than 10 new KS lesions in the prior month, symptomatic lymphedema, symptomatic pulmonary KS, or symptomatic visceral involvement. There is no experience to date using alitretinoin with systemic anti-KS treatment. History Ligand gained Food and Drug Administration FDA approval for alitretinoin in February 1999. References ^ WHO International Working Group for Drug Statistics Methodology August 27, 2008. ATC/DDD Classification FINAL: New ATC 5th level codes. WHO Collaborating Centre for Drug Statistics Methodology. Retrieved on 2008-09-05. External links Prescribing Information revised February 2007. Retrieved on 01-30-08. v d e Chemotherapeutic agents/Antineoplastic agents L01 Purine+pyrimidine/ Ribonucleotides/ Deoxyribonucleotides Antimetabolites Folic acid Aminopterin, Methotrexate, Pemetrexed, Raltitrexed Purine Cladribine, Clofarabine, Fludarabine, Mercaptopurine, Pentostatin, Thioguanine Pyrimidine Cytarabine, Decitabine, Fluorouracil/Capecitabine, Floxuridine, Gemcitabine, Enocitabine, Sapacitabine DNA Alkylating/alkylating-like Nitrogen mustards Chlorambucil, Chlormethine, Cyclophosphamide, Ifosfamide, Melphalan, Bendamustine, Trofosfamide, Uramustine Nitrosoureas Carmustine, Fotemustine, Lomustine, Nimustine, Prednimustine, Ranimustine, Semustine, Streptozocin Platinum alkylating-like Carboplatin, Cisplatin, Nedaplatin, Oxaliplatin, Triplatin tetranitrate, Satraplatin Alkyl sulfonates Busulfan, Mannosulfan, Treosulfan Hydrazines Procarbazine Triazenes Dacarbazine, Temozolomide Aziridines Carboquone, ThioTEPA, Triaziquone, Triethylenemelamine Spindle poisons/mitotic inhibitors Taxanes Docetaxel, Larotaxel, Ortataxel, Paclitaxel, Tesetaxel · Vinca alkaloids Vinblastine, Vincristine, Vinflunine, Vindesine, Vinorelbine · Ixabepilone Cytotoxic/antitumor antibiotics Anthracyclines Aclarubicin, Daunorubicin, Doxorubicin, Epirubicin, Idarubicin, Amrubicin, Pirarubicin, Valrubicin, Zorubicin Anthracenediones Mitoxantrone, Pixantrone Streptomyces Actinomycin, Bleomycin, Mitomycin, Plicamycin · Hydroxyurea Topoisomerase inhibitors Camptotheca Camptothecin, Topotecan, Irinotecan, Rubitecan, Belotecan · Podophyllum Etoposide, Teniposide Other Altretamine · Amsacrine · Bexarotene · Estramustine · Irofulven · Trabectedin Cellular CI monoclonal antibodies Receptor tyrosine kinase Cetuximab, Panitumumab, Trastuzumab · CD20 Rituximab, Tositumomab · other Alemtuzumab, Bevacizumab, Edrecolomab, Gemtuzumab Tyrosine kinase inhibitors Axitinib · Bosutinib · Cediranib · Dasatinib · Erlotinib · Gefitinib · Imatinib · Lapatinib · Lestaurtinib · Nilotinib · Semaxanib · Sorafenib · Sunitinib · Vandetanib Cyclin-dependent kinase inhibitors Alvocidib · Seliciclib Other Fusion protein Aflibercept · Denileukin diftitox Other/ungrouped Photosensitizers Aminolevulinic acid/Methyl aminolevulinate · Efaproxiral · Porphyrin derivatives Porfimer sodium, Talaporfin, Temoporfin, Verteporfin Other Retinoids Alitretinoin, Tretinoin · Anagrelide · Arsenic trioxide · Asparaginase/Pegaspargase · Atrasentan · Bortezomib · Carmofur · Celecoxib · Demecolcine · Elesclomol · Elsamitrucin · Etoglucid · Lonidamine · Lucanthone · Masoprocol · Mitobronitol · Mitoguazone · Mitotane · Oblimersen · Omacetaxine · Sitimagene ceradenovec · Tegafur · Testolactone · Tiazofurine · Tipifarnib · Vorinostat v d e Carotenoids Carotenes: Carotene Alpha-carotene · Beta-carotene · Lycopene · Phytoene Phytofluene · Neurosporene Retinoids: Acitretin · Alitretinoin · Apocarotenal · Bexarotene · Etretinate · Fenretinide · Isotretinoin · Retinaldehyde · Tazarotene · Vitamin A Retinol, Tretinoin Xanthophylls: Antheraxanthin · Astaxanthin · Canthaxanthin · Citranaxanthin · Cryptoxanthin · Diadinoxanthin · Diatoxanthin · Dinoxanthin · Flavoxanthin · Fucoxanthin · Lutein · Neoxanthin · Rhodoxanthin · Rubixanthin · Violaxanthin · Zeaxanthin Other: Crocin · Crocetin · Peridinin · Food orange 7 Retrieved from http://en..org/wiki/Alitretinoin Categories: Retinoids Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 5 September 2008, at 16:32

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