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14-September-2008 18:38:44 - Choline Choline IUPAC name 2-Hydroxyethyltrimethylammonium Identifiers CAS number 62-49-7 PubChem 305 MeSH Choline SMILES CN+CCCCO ChemSpider ID 299 Properties Molecular formula C5H14NO+ Molar mass 104.17 g/mol Except where noted otherwise, data are given for materials in their standard state at 25 °C, 100 kPa Infobox references Choline is an organic compound, classified as a water-soluble essential nutrient123 and usually grouped within the Vitamin B complex. This natural amine is found in the lipids that make up cell membranes and in the neurotransmitter acetylcholine. Adequate intakes AI for this micronutrient of between 425 to 550 milligrams daily, for adults, have been established by the Food and Nutrition Board of the Institute of Medicine of the National Academy of Sciences. Contents 1 History 2 Chemistry 3 Physiology 4 Choline as a supplement 5 Fish odor syndrome 6 Choline hydroxide 7 Sources 8 Additional images 9 References History Choline was discovered by Andreas Strecker in 1864 and chemically synthesized in 1866. In 1998 choline was classified as an essential nutrient by the Food and Nutrition Board of the Institute of Medicine U.S.A.. Chemistry Choline is a quaternary saturated amine with the chemical formula CH33N+CH2CH2OHX-, where X- is a counterion such as chloride see choline chloride, hydroxide or tartrate. Choline chloride, in mixture with urea is used as a solvent DES and the salicylate salt is used topically for pain relief of aphthous ulcers. Physiology Choline metabolism. Choline is green box at left, second from the bottom. Choline metabolism. Choline is green box at left, second from the bottom. Choline and its metabolites are needed for three main physiological purposes: structural integrity and signaling roles for cell membranes, cholinergic neurotransmission acetylcholine synthesis, and as a major source for methyl groups via its metabolite, trimethylglycine betaine that participates in the S-adenosylmethionine synthesis pathways. When choline is metabolized by the body, it may form trimethylamine, a compound with a fishy odor. Hence, when large amounts of choline are taken the person may suffer from a fishy body odor. Choline as a supplement It is well established that supplements of methyl group transfer vitamins B6, B12, folic acid reduce the blood titer of homocysteine and prevent heart disease. Choline is a necessary source of methyl groups for methyl group transfer. Supplements of lecithin/choline by Central Soya scientists reduced heart disease in laboratory studies. The reduction in heart disease with lecithin supplements may however relate more to the cholesterol carrying capacity of lecithin than to the methyl group transfer role of choline.specify Choline supplements are often taken as a form of 'smart drug' or nootropic, due to the role that the neurotransmitter acetylcholine plays in various cognition systems within the brain. Choline is a chemical precursor or building block needed to produce the neurotransmitter acetylcholine, and research suggests that memory, intelligence and mood are mediated at least in part by acetylcholine metabolism in the brain. The compound's quaternary amine renders it lipid insoluble which might suggest it would be unable to cross the blood-brain barrier. However, despite choline's lipid insolubility, a choline transporter exists that allows transport across the blood-brain barrier. The efficacy of these supplements in enhancing cognitive abilities is a topic of continuing debate. Lakhan Vieira 20084 link choline deficiency to bipolar disorder and report efficacy in lecithin supplementation based on a double-blind, placebo controlled trial. Some people who practice lucid dreaming use Galantamine with choline bitartrate or Alpha GPC to increase their odds of having a lucid dream. Acetylcholine precursors such as choline work synergistically with Galantamine to help improve memory and the symptoms of Alzheimer's Disease AD. The Food and Drug Administration FDA requires that infant formula not made from cow's milk be supplemented with choline.5 Due to its role in lipid metabolism, choline has also found its way into nutritional supplements which claim to reduce body fat; but there is little or no evidence to prove that it has any effect on reducing excess body fat or that taking high amounts of choline will increase the rate at which fat is metabolised. Fish odor syndrome Main article: trimethylaminuria Choline is a precursor to trimethylamine, which some persons are not able to break down due to a genetic disorder. Persons suffering from this disorder, called trimethylaminuria, may suffer from a strong fishy or otherwise unpleasant body odor due to the body's release of odorous trimethylamine. A body odor will occur even on a normal diet - i.e., one that is not particularly high in choline. Persons with trimethylaminuria are advised to restrict the intake of foods high in choline; this may help to reduce the sufferer's body odor. Choline hydroxide Choline hydroxide is one of the class of phase transfer catalysts which are used to carry the hydroxide ion into organic systems. It is far and away the least costly phase transfer catalyst, and gets a lot of use in stripping photoresists in printed circuit board production. Choline hydroxide is not completely stable and it spontaneously, slowly breaks down to release trimethylamine. It is a strong base. bot2x na. Sources The foods richest in phosphatidylcholine - the major delivery form of choline - are egg yolks, soy and cooked beef, chicken, veal and turkey livers. Many foods contain trace amounts of free choline, even iceberg lettuce. To what extent these trace forms are usable by human digestion is still debated. In 2004, the USDA released its first database of the choline content in common foods.6 The most often available choline dietary supplement is lecithin, derived from soy or egg yolks, often used as a food additive. Phosphatidylcholine is also available as a supplement, in pill or powder form. Supplementary choline is also available as choline chloride, which comes as a liquid due to its hydrophilic properties. Choline chloride is sometimes preferred as a supplement because phosphatidylcholine can have gastrointestinal side effects. Additional images Choline C5H14NO+ Choline chloride Choline hydroxide Synthesis References ^ Jane Higdon, Choline, Micronutrient Information Center, Linus Pauling Institute ^ Choline, PDRHealth ^ Choline An interview with Steven Zeisel, or-in-Chief of the Journal of Nutritional Biochemistry, Radio National Health Report with Norman Swan, Monday 17 April 2000 ^ Lakhan SE; Vieira KF. Nutritional therapies for mental disorders. Nutrition Journal 2008;72. ^ Isadora B. Stehlin, Infant Formula: Second Best but Good Enough, U.S. Food and Drug Administration. ^ USDA Database for the Choline Content of Common Foods - 2004, USDA Nutrient Data Laboratory v d e Vitamins A11 Fat soluble A: Retinol - Beta-carotene - Tretinoin - Alpha-carotene D3: 7-Dehydrocholesterol → Previtamin D3 → Cholecalciferol D3 → Calcidiol → Calcitriol active form → Calcitroic acid D2: Ergosterol → Ergocalciferol D2 D analogues: Dihydrotachysterol - Calcipotriol - Tacalcitol D4: Dihydroergocalciferol E: Tocopherol - Tocotrienol K: Naphthoquinone - Phylloquinone/K1 - Menatetrenone/K2 Water soluble: B vitamins B1 Thiamine - B2 Riboflavin - B3 Niacin, Nicotinamide - B5 Pantothenic acid, Dexpanthenol, Pantethine - B6 Pyridoxine, Pyridoxal phosphate, Pyridoxamine - B7 Biotin - B9 Folic acid, Folinic acid - B12 Cyanocobalamin, Hydroxocobalamin, Methylcobalamin, Cobamamide Water soluble: other C Ascorbic acid - Choline see also enzyme cofactors Retrieved from http://en..org/wiki/Choline Categories: Alcohols | Quaternary ammonium compounds | Dietary supplements | Nutrition | VitaminsHidden category: Articles needing more detailed references Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Dansk Deutsch Français עברית Lietuvių Nederlands 日本語 Polski РуÑ?Ñ?кий Simple English SlovenÄ?ina Suomi Svenska Türkçe This page was last modified on 31 August 2008, at 16:43
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