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07-SEPTEMBER-2008 03:17:44 - protein Merge arrow It has been suggested that this article or section be merged into APC gene. Discuss APC adenomatosis polyposis coli is the product of a tumor suppressor gene APC gene. The human full-length protein comprises 2843 AA with a predicted molecular mass of 311646 Da. Most domains of this protein are solved structurally and exhibit high intrinsic disorder/flexibility as monomer and a low content of stable secondary structure. Thus it is a member of the intrinsically unstructured proteins Intrinsically unstructured proteins. Nothing is known about in vivo full-length unfoldome which is nice for some investigators but bad for current therapeutic intervention ... List of some ... point mutants L852M P865S S906Y E911G S966R Y1027C T1018C S1081I D1083E Q1096H E1284G E1284K A1305S E1306K K1308E E1317Q P1319T S1321N V1326M E1353V F1354L G1357R S1364R Q1367H P1373T S1389F S1389T S1385R L1393P S1395C S1398N S1415I D1422H D1425A S1434I K1468N G1534R S1599L References Point mutants : PMID 12619115 PMID 14695993 PMID 1528264 PMID 8395678 PMID 12093899 PMID 9924427 PMID 15072829 PMID 12833148 PMID 8764128 PMID 11315765 PMID 10638959 PMID 11819789 PMID 8055154 PMID 9014854 PMID 11048797 PMID 7881432 PMID 9482574 PMID 14502807 PMID 17882487 External links Database concerning peer-reviewed reports on cancer critical alteration in several genes including APC protein, TP53, β-catenin Retrieved from http://en..org/wiki/APC_protein Categories: Human proteinsHidden category: Articles to be merged since November 2007 Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 10 August 2008, at 17:28
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