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07-SEPTEMBER-2008 03:17:44 - Alpha catenin catenin cadherin-associated protein, alpha 1, 102kDa Identifiers Symbol CTNNA1 Entrez 1495 HUGO 2509 OMIM 116805 RefSeq NM_001903 UniProt P35221 Other data Locus Chr. 5 q31.2 catenin cadherin-associated protein, alpha 2 Identifiers Symbol CTNNA2 Entrez 1496 HUGO 2510 OMIM 114025 RefSeq NM_004389 UniProt P26232 Other data Locus Chr. 2 p12-p11.1 catenin cadherin-associated protein, alpha 3 Identifiers Symbol CTNNA3 Entrez 29119 HUGO 2511 OMIM 607667 RefSeq NM_013266 UniProt Q9UI47 Other data Locus Chr. 10 q21 Alpha-catenin was suggested to function as a linking protein between cadherins and actin-containing filaments of the cytoskeleton.1 It has been reported that the actin binding proteins vinculin2 and alpha-actinin3 can bind to alpha-catenin. However, a protein complex including a cadherin, actin, beta-catenin and alpha-catenin has not been isolated. It has been suggested that alpha-catenin does not bind with high affinity to both actin filaments and the E-cadherin-beta-catenin complex at the same time.4 It has been observed that when alpha-catenin is not in a molecular complex with beta-catenin, it dimerizes and functions to regulate actin filament assembly, possibly by competing with Arp2/3 protein.5 The amino acid sequence of alpha-catenin has sequence similarity to that of vinculin.6 Contents 1 Types 2 See also 3 External links 4 References Types There are three human alpha-catenin genes: alpha-1-catenin also called alpha-E-catenin alpha-2-catenin also called alpha-N-catenin alpha-3-catenin See also Catenin External links MeSH alpha+Catenin References ^ Model of attachment of actin filaments to catenin-cadherin complexes. Figure 11.14 in The Cell: A Molecular Approach second ion by Geoffrey M. Cooper 2000 Published by Sinauer Associates, Inc. ISBN 0878932194 . ^ M. Watabe-Uchida, N. Uchida, Y. Imamura, A. Nagafuchi, K. Fujimoto, T. Uemura, S. Vermeulen, F. van Roy, E. D. Adamson and M. Takeichi. alpha-Catenin-vinculin interaction functions to organize the apical junctional complex in epithelial cells in Journal of Cell Biology 1998 Volume 142, pages 847-857. Entrez PubMed 9700171 ^ K. A. Knudsen, A. P. Soler, K. R. Johnson and M. J. Wheelock Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin in Journal of Cell Biology 1995 Volume 130, pages 67-77. Entrez PubMed 7790378 ^ S. Yamada, S. Pokutta, F. Drees, W. I. Weis and W. J. Nelson Deconstructing the cadherin-catenin-actin complex in Cell 2005 Volume 123, pages 889-901. Entrez PubMed 16325582 ^ F. Drees, S. Pokutta, S. Yamada, W. J. Nelson and W. T. Weis. Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly in Cell 2005 Volume 123, pages 903-915. Entrez PubMed 16325583 ^ A. Nagafuchi, M. Takeichi, and S. Tsukita. The 102 kd cadherin-associated protein: similarity to vinculin and posttranscriptional regulation of expression in Cell 1991 Volume 65, pages 849-857. Entrez PubMed 1904011 This article on a gene on chromosome 10 is a stub. v d e Proteins of the cytoskeleton Microfilaments Actins - Actin-binding proteins - Actinin - Arp2/3 complex - Cofilin - Destrin - Gelsolin - Myosins - Profilin - Tropomodulin - Troponin T, C, I - Tropomyosin - Wiskott-Aldrich syndrome protein Intermediate filaments type 1 and 2 Cytokeratin, type I, type II - type 3 Desmin, GFAP, Peripherin, Vimentin - type 4 Internexin, Nestin, Neurofilament, Synemin, Syncoilin - type 5 Lamin A, B Microtubules Dyneins - Kinesins - MAPs Tau protein, Dynamin - Tubulins - Stathmin - Tektin Catenins Alpha catenin - Beta catenin - Plakoglobin gamma catenin - Delta catenin Nonhuman Major sperm proteins - Prokaryotic cytoskeleton Crescentin, FtsZ, MreB Other APC - Dystrophin Dystroglycan - plakin Desmoplakin, Plectin - Spectrin - Talin - Utrophin - Vinculin Retrieved from http://en..org/wiki/Alpha_catenin Categories: Genes on chromosome 5 | Genes on chromosome 2 | Genes on chromosome 10 | Chromosome 10 gene stubsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 6 May 2008, at 04:58
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So many of us do not eat a balanced diet, get enough sleep, have too much stress, or are impacted with toxins and pollutants. Drinking 2 ounces of MonaVie twice a day will help your body detoxify as well as build your immune system. Its the smartest thing you can do for yourself, so start today. Buying MonaVie through our company guarantees you support 7 days a week and, if you would like to share MonaVie with your family and friends we will guide you from start to finish.
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