Sierra Acai Company
Sierra Acai Company
Open 7 Days a Week
MonaVie Independent Distributor
Distributor Training
Shop Online
Enroll Now
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
Friends
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
07-SEPTEMBER-2008 03:17:44 - Anandamide Anandamide IUPAC name 5Z,8Z,11Z,14Z- N-2-hydroxyethyl icosa-5,8,11,14-tetraenamide or arachidonoylethanolamide Identifiers CAS number 94421-68-8 PubChem 5281969 MeSH Anandamide SMILES CCCCC\C=C/C\C=C/C\C=C /C\C=C/CCCCNCCO=O Properties Molecular formula C22H37NO2 Molar mass 347.53 g/mol Except where noted otherwise, data are given for materials in their standard state at 25 °C, 100 kPa Infobox references Anandamide, also known as arachidonoylethanolamide or AEA, is an endogenous cannabinoid neurotransmitter found in animal and human organs, especially in the brain. It was isolated and its structure was first described by Czech analytical chemist LumÃr OndÅ™ej HanuÅ¡ and American molecular pharmacologist William Anthony Devane in the Laboratory of Raphael Mechoulam, at the Hebrew University in Jerusalem, Israel in 1992. The name is taken from the Sanskrit word ananda, which means bliss, delight, and amide.12 It is degraded by the fatty acid amide hydrolase FAAH enzyme which converts anandamide into ethanolamine and arachidonic acid. As such, inhibitors of FAAH lead to elevated anandamide levels and are being pursued for therapeutic use. Contents 1 Cannabinoid receptors 2 Endogenous and dietary sources 3 See also 4 References 5 External links Cannabinoid receptors Anandamide's effects can be either central, in the brain, or peripheral, in other parts of the body. These distinct effects are mediated primarily by CB1 cannabinoid receptors in the nervous system, and CB2 cannabinoid receptors in the periphery. The latter is mainly involved in functions of the immune system. Cannabinoid receptors are part of the largest known family of receptors, the G protein-coupled receptors, which - in this case - has a distinctive pattern in which the receptor molecule spans the cell membrane seven times over. The CB1 receptor is one of the most numerous G protein-coupled receptors in the nervous system. Cannabinoid receptors were originally discovered as being sensitive to Δ9-tetrahydrocannabinol Δ9-THC, commonly called THC, which is the primary psychoactive cannabinoid found in cannabis. The discovery of anandamide came from research into CB1 and CB2, as it was inevitable that a naturally occurring endogenous chemical would be found to affect these receptors. Anandamide has been shown to be involved in working memory3. Studies are under way to explore what role anandamide plays in human behavior, such as eating and sleep patterns, and pain relief. Anandamide is also important for implantation of the early stage embryo in its blastocyst form into the uterus. Therefore cannabinoids such as Δ9-THC might interfere with the earliest stages of human pregnancy4. Anandamide also is important in the regulation of feeding behavior, and the neural generation of motivation and pleasure. Both anandamide and exogenous cannabinoids like THC enhance food intake in animals and humans, an effect that is sometimes called the 'marijuana munchies.' In addition, anandamide injected directly into the forebrain reward-related brain structure nucleus accumbens enhances the pleasurable responses of rats to a rewarding sucrose taste, and enhances food intake as well. Moreover, anandamide is thought to be an endogenous ligand for vanilloid receptors which are involved in the transduction of acute and inflammatory pain signals, activating the receptor in a PKC-dependent protein kinase C-dependent manner. Raphael Mechoulam right, discoverer of psychoactive compound, --trans-delta-9-tetrahydrocannabinol, from Cannabis sativa L. 1964 and LumÃr OndÅ™ej HanuÅ¡ left, discoverer of endogenous ligand, anandamide, from brain 1992. Both compounds bind to the cannabinoid receptors in the brain. Raphael Mechoulam right, discoverer of psychoactive compound, --trans-delta-9-tetrahydrocannabinol, from Cannabis sativa L. 1964 and LumÃr OndÅ™ej HanuÅ¡ left, discoverer of endogenous ligand, anandamide, from brain 1992. Both compounds bind to the cannabinoid receptors in the brain. Endogenous and dietary sources Anandamide occurs in minute quantities in sea urchin roe.5 Anandamide was reported to be present in chocolate6 in small quantitities that were not assumed to have pharmacological or psychoactive effects.7 However, a later study failed to repeat these findings and did not detect anandamide in chocolate.8 The human body synthesizes anandamide from N-arachidonoyl phosphatidylethanolamine, which is itself made by transferring arachidonic acid from phosphatidylcholine PC to the free amine of phosphatidylethanolamine PE.910 Endogenous anandamide is present at very low levels and has a very short half-life due to the action of the enzyme fatty acid amide hydrolase which breaks it down into free arachidonic acid and ethanolamine. Studies of piglets show that dietary levels of AA and other essential fatty acids affect the levels of anandamide and other endocannabinoids in the brain.11 High fat diet feeding in mice increase levels of Anandamide in the liver and increase lipogenesis.12 This indicates that Anandamide plays a role in the development of obesity, at least in rodents. A study lead in 1998 shows that anandamide inhibits human breast cancer cell proliferation.13 See also Cannabinoids Tetrahydrocannabinol THC 2-Arachidonoylglycerol Fatty acid amide hydrolase References ^ Devane W. A., HanuÅ¡ L., Breuer A., Pertwee R. G., Stevenson L. A., Griffin G., Gibson D., Mandelbaum A., Etinger A., Mechoulam R.: Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258, 1946-1949 1992 ^ Mechoulam R., Fride E.: The unpaved road to the endogenous brain cannabinoid ligands, the anandamides in Cannabinoid Receptors ed. R. Pertwee, Academic Press, London. Pp. 233-258 1995 ^ Mallet PE, Beninger RJ. The endogenous cannabinoid receptor agonist anandamide impairs memory in rats. Behav Pharmacol. 1996; 7:276-284. ^ Piomelli D. THC: moderation during implantation. Nat Med. 2004 Jan;101:19-20. PMID 14702623 ^ Bisogno T, Ventriglia M, Milone A, Mosca M, Cimino G, Di Marzo V. Occurrence and metabolism of anandamide and related acyl-ethanolamides in ovaries of the sea urchin Paracentrotus lividus. Biochim Biophys Acta. 1997 Apr 21;13453:338-48. PMID 9150253 ^ E. di Tomaso, M. Beltramo, D. Piomelli 1996. Brain cannabinoids in chocolate. Nature 382 6593: 677-678. doi:10.1038/382677a0. PMID 8751435. ^ Di Marzo V, Sepe N, De Petrocellis L, et al 1998. Trick or treat from food endocannabinoids?. Nature 396 6712: 636-7. doi:10.1038/25267. PMID 9872309. ^ GC Willi, A Berger, V Di Marzo, T Bisogno, L De 2001. Lipids in Neural Function: Modulation of Behavior by Oral Administration of Endocannabinoids Found in Foods. Nestle Nutr Workshop Ser Clin Perform Programme 5: 169-84; discussion 185-7. PMID 11510437. ^ V Natarajan, PV Reddy, PC Schmid, HH Schmid, N-Acylation of ethanolamine phospholipids in canine myocardium, Biochem. Biophys. Acta, 1982, Vol 712, 342-355, PMID 7126608 ^ H Cadas, E di Tamaso, D Piomelli, Occurrence and biosynthesis of endogenous cannabinoid precursor, N-arachidonoyl phosphatidylethanolamine, in rat brain., J Neurosci, 1997, Vol 174, 1226-42. PMID 9006968 ^ Alvin Berger, Anandamide and diet: Inclusion of dietary arachidonate and docosahexaenoate leads to increased brain levels of the corresponding N-acylethanolamines in piglets, PNAS, May 22, 2001 vol. 9, no. 11, http://www.pnas.org/cgi/content/abstract/98/11/6402 ^ Osei-Hyiaman D, DePetrillo M, Pacher P, Liu J, Radaeva S, Bátkai S, Harvey-White J, Mackie K, Offertáler L, Wang L, Kunos G, Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity, J Clin Invest. 2005 May;1155:1298-305. PMID: 15864349 ^ Luciano De Petrocellis, Dominique Melck, Antonella Palmisano, Tiziana Bisogno, Chiara Laezza, Maurizio Bifulco, Vincenzo Di Marzo 1998. The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation. Proceedings of the National Academy of Sciences 95: 8375. doi:10.1073/pnas.95.14.8375. PMID 9653194. External links v d e Cannabinoids Plant cannabinoids CBD CBDV CBN CBG CBV CBL THC THC-C4 THCV Cannabinoid metabolites 11-Hydroxy-THC 11-nor-9-Carboxy-THC Endogenous cannabinoids Arachidonoyl ethanolamide Anandamide or AEA 2-Arachidonoylglycerol 2-AG 2-Arachidonyl glyceryl ether noladin ether Virodhamine N-arachidonoyl-dopamine NADA; Oleamide Synthetic cannabinoid agonists Classical cannabinoids Dibenzopyrans A-41988 Ajulemic acid AM-087 AM-411 AM-855 AM-905 AM-906 AM-919 AM-938 AM-4030 AMG-1 AMG-3 AMG-36 AMG-41 Dexanabinol HU-211 DMHP Dronabinol HU-210 JWH-051 JWH-133 JWH-139 L-759,633 L-759,656 Levonantradol Nabilone Nabitan O-806 O-823 O-1057 O-1125 O-1238 O-2545 O-2694 Parahexyl THC-O-acetate THC-O-phosphate Nonclassical cannabinoids CP 47,497 CP 55,244 CP 55,940 HU-308 2-Isopropyl-5-methyl-1-2,6-dihydroxy-4-nonylphenylcyclohex-1-ene Aminoalkylindoles AM-630 AM-1241 JWH-015 JWH-018 JWH-073 JWH-081 JWH-200 L-768,242 Pravadoline WIN 55,212-2 Aminoalkylpyrroles JWH-030 JWH-147 JWH-307 Eicosanoids AM-883 Arachidonyl-2'-chloroethylamide Arachidonylcyclopropylamide Methanandamide O-585 O-689 O-1812 O-1860 O-1861 Others BAY 38-7271 BAY 59-3074 GW 842,166X JWH-171 O-2220 Endocannabinoid activity enhancers AM-404 CAY-10401 CAY-10402 N-arachidonoyl-serotonin O-1624 PF-622 PF-750 URB-597 URB-602 URB-754 Cannabinoid antagonists and inverse agonists AM-251 AM-281 AM-630 AVE-1625 BML-190 CAY-10508 CB-25 CB-52 JTE-907 LY-320,135 MK-9470 NESS-0327 O-1184 O-2050 O-2654 Rimonabant SLV-319 SR-144,528 Surinabant Taranabant VCHSR Retrieved from http://en..org/wiki/Anandamide Categories: Cannabinoids | Neurotransmitters | Amides | Biomolecules Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages ÄŒesky Deutsch Español Français Italiano עברית Magyar Nederlands 日本語 ‪Norsk bokmÃ¥l‬ Polski РуÑ?Ñ?кий Suomi Svenska This page was last modified on 8 August 2008, at 01:5
39 Reasons to Drink Acai Juice Every Day
What is MonaVie - Watch the 8-minute video
Discovering MonaVie Video
The Power of You Video
Effects of MonaVie Active on Antioxidant Capacity in Humans
Log into your Wholesale MonaVie Account
So many of us do not eat a balanced diet, get enough sleep, have too much stress, or are impacted with toxins and pollutants. Drinking 2 ounces of MonaVie twice a day will help your body detoxify as well as build your immune system. Its the smartest thing you can do for yourself, so start today. Buying MonaVie through our company guarantees you support 7 days a week and, if you would like to share MonaVie with your family and friends we will guide you from start to finish.
1. Click on Enroll Now (30 - 55% off retail price)
2. Pay $39 for your Wholesale ID number.
3. NO minimum order required.
4. MonaVie is delivered to your door in 3 to 5 days.