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Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
07-SEPTEMBER-2008 03:17:44 - Benazepril Benazepril Systematic IUPAC name 2-4S-4-1S-1-ethoxycarbonyl-3-phenyl-propylamino- 3-oxo-2-azabicyclo5.4.0undeca-7,9,11-trien-2-ylacetic acid Identifiers CAS number 86541-75-5 ATC code C09AA07 PubChem 5362124 DrugBank APRD00063 Chemical data Formula C24H28N2O5 Mol. mass 424.49 g/mol Pharmacokinetic data Bioavailability ? Protein binding 96.7% Metabolism Hepatic glucuronidation Half life 10-11 hours Excretion Renal and biliary Therapeutic considerations Pregnancy cat. D Legal status â„ž Prescription only Routes Oral Benazepril, brand name Lotensin, is a medication used to treat high blood pressure hypertension, congestive heart failure, and chronic renal failure. Upon cleavage of its ester group by the liver, benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme ACE inhibitor. Contents 1 Dosage forms 2 Side effects 3 Contraindications 4 Kidney disease 4.1 Veterinary use 5 References 6 External links Dosage forms Oral tablets, 5 mg, 10 mg, 20 mg, and 40 mg. Benazepril is also available in combination with hydrochlorothiazide, under the trade name Lotensin HCT, and with amlodipine trade name Lotrel. Side effects Most commonly, headache and cough. Anaphylaxis and angioedema can occur. Hyperkalemia, or an elevation of potassium levels, can also occur. Benazepril may cause harm to the fetus during pregnancy. Contraindications Benazepril should be discontinued during pregnancy. Kidney disease According to a 2006 article in the New England Journal of Medicine, patients with advanced renal insufficiency taking benazepril showed substantial kidney benefits.1 A long term study of patients' kidney disease revealed that patients who took benazepril had better kidney function and a slower progression of kidney disease. Kidney function was much better in the group of patients taking the drug than their peers who took a placebo drug.2 This is notable because this category of pharmaceuticals have long been thought to cause further kidney damage or increase the rate of progression for kidney disease. According to coverage of the study on WebMD: ACE inhibitors can pose a potential threat to kidneys as well. The key question was whether damaged kidneys would worsen if patients took ACE inhibitors. In a nutshell, concerns centered on blood levels of potassium and creatinine, waste products that are excreted by the kidneys. Testing creatinine levels in the blood is used as a way to monitor kidney function ... kidney problems worsened more slowly in those taking Lotensin. Overall, there were no major differences in side effects between patients taking Lotensin or the placebo.2 This study marks the first indication that benazepril, and perhaps other ACE inhibitors, may actually be beneficial in the treatment of hypertension in patients with kidney disease. Veterinary use Under the brand name Fortekor Novartis, benazepril hydrochloride is used to treat congestive heart failure in dogs and chronic renal failure in cats. References ^ Hou F, Zhang X, Zhang G, Xie D, Chen P, Zhang W, Jiang J, Liang M, Wang G, Liu Z, Geng R 2006. Efficacy and safety of benazepril for advanced chronic renal insufficiency. N Engl J Med 354 2: 131-40. doi:10.1056/NEJMoa053107. PMID 16407508. ^ a b Hitti, Miranda; Chang, Louise January 11, 2006. Drug May Treat Advanced Kidney Disease. WebMD. Retrieved on 2006-09-07. External links Prescribing Information for Lotensin v d e Agents acting on the renin-angiotensin system C09 ACE inhibitors Alacepril Benazepril Captopril Cilazapril Delapril Enalapril Fosinopril Imidapril Lisinopril Moexipril Perindopril Quinapril Ramipril Rentiapril Spirapril Temocapril Trandolapril Zofenopril Angiotensin II receptor antagonists AIIRA Azilsartan Candesartan Eprosartan Irbesartan Losartan Olmesartan Tasosartan Telmisartan Valsartan Renin inhibitors Aliskiren Remikiren Retrieved from http://en..org/wiki/Benazepril Categories: ACE inhibitors | Prodrugs Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Italiano Magyar 日本語 Português СрпÑ?ки / Srpski This page was last modified on 19 July 2008, at 14:17
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So many of us do not eat a balanced diet, get enough sleep, have too much stress, or are impacted with toxins and pollutants. Drinking 2 ounces of MonaVie twice a day will help your body detoxify as well as build your immune system. Its the smartest thing you can do for yourself, so start today. Buying MonaVie through our company guarantees you support 7 days a week and, if you would like to share MonaVie with your family and friends we will guide you from start to finish.
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