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07-SEPTEMBER-2008 03:17:44 - Bence Jones protein A Bence Jones protein is a monoclonal globulin protein found in the blood or urine. Finding this protein in the context of end-organ manifestations such as malignant bone marrow cancer, renal failure, lytic bone disease, or anemia, or large numbers of plasma cells in the bone marrow of patients can be diagnostic of multiple myeloma, in which it is present in 2/3 of cases.1 The proteins are antibody immunoglobulin free light chains paraproteins and are produced by neoplastic plasma cells. They can be kappa most of the time or lambda.1 The light chains can be immunoglobulin fragments or single homogenous immunoglobulins. They are found in urine as they are small and hence easily cleared by the kidneys. The light chains can be detected by heating or electrophoresis of concentrated urine. Light chains precipitate when heated to 50 - 60 degrees C and redisolve at 90 -100 degrees C. These tests are essential in patients suspected of having Bence Jones proteins in their urine as these proteins don't react with the reagents normally utilized in urinalysis dipsticks. This leads to false negative results in people with Bence Jones proteins in their urine undergoing standard urinalysis. There are various rarer conditions which can produce Bence Jones proteins, such as Waldenström's macroglobulinemia and other malignanices. The Bence Jones protein was described by the English physician Henry Bence Jones in 1847 and published in 1848.2 The protein was later sequenced by Frank Putnam at the laboratory of Fred Sanger in Cambridge, who was the first to report the entire sequence. References ^ a b Hoffbrand V, Moss P, Pettit J 2006. Essential Haematology Essential, 5th ion, Blackwell Publishing Professional, 218. ISBN 1405136499. ^ Jones HB 1848. On a new substance occurring in the urine of a patient with mollities ossium. Phil Trans R Soc Lond 138: 55-62. doi:10.1098/rstl.1848.0003. This immunology article is a stub. v d e Eponymous medical signs for hematology Hematology Arneth count - Apt test - Auer rod - Cabot rings - Coombs test - Döhle bodies - Mentzer index - Russell bodies - Virchow's triad - Howell-Jolly body Retrieved from http://en..org/wiki/Bence_Jones_protein Categories: Medical tests | Hematology | Immunology stubs Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Deutsch Français This page was last modified on 6 August 2008, at 19:38
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So many of us do not eat a balanced diet, get enough sleep, have too much stress, or are impacted with toxins and pollutants. Drinking 2 ounces of MonaVie twice a day will help your body detoxify as well as build your immune system. Its the smartest thing you can do for yourself, so start today. Buying MonaVie through our company guarantees you support 7 days a week and, if you would like to share MonaVie with your family and friends we will guide you from start to finish.
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