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07-SEPTEMBER-2008 03:17:44 - trachomatis Chlamydia trachomatis C. trachomatis inclusion bodies brown in a McCoy cell culture. C. trachomatis inclusion bodies brown in a McCoy cell culture. Scientific classification Kingdom: Bacteria Phylum: Chlamydiae Order: Chlamydiales Family: Chlamydiaceae Genus: Chlamydia Species: C. trachomatis Binomial name Chlamydia trachomatis Busacca, 1935 Chlamydia trachomatis, an obligate intracellular human pathogen, is one of three bacterial species in the genus Chlamydia, family Chlamydiaceae, class Chlamydiae, phylum Chlamydiae, domain Bacteria. C. trachomatis cannot be stained with the Gram stain it is Gram negative. C. trachomatis was the first chlamydial agent discovered in humans. It was identified in 1907.1 It comprises three human biovars: Urethritis serovars D-K, trachoma serovars A, B, Ba or C and lymphogranuloma venereum LGV, serovars L1, 2 and 3. Many, but not all,2 C. trachomatis strains have an extrachromosomal plasmid. Contents 1 Clinical significance 2 Identification 3 References 4 External links Clinical significance It has only been found living inside the cells of humans, causing the following conditions: In men Prostatitis Epididymitis In women Cervicitis Pelvic inflammatory disease PID Ectopic pregnancy Pelvic pain, chronic or acute Newborn eye trachoma or lung infection In both sexes Urethritis Infertility Proctitis rectal disease and bleeding Reactive arthritis Trachoma C. trachomatis has also been detected in some patients with temporomandibular joint disease TMJ. It may be treated with any of several antibiotics: azithromycin, erythromycin or doxycycline/tetracycline. Identification Chlamydia species are readily identified and distinguished from other chlamydial species using DNA-based tests. Most strains of C. trachomatis are recognized by monoclonal antibodies mAbs to epitopes in the VS4 region of MOMP.3 However, these mAbs may also crossreact with the other two Chlamydia species, Chlamydia suis and Chlamydia muridarum. References ^ Budai I 2007. Chlamydia trachomatis: milestones in clinical and microbiological diagnostics in the last hundred years: a review. Acta microbiologica et immunologica Hungarica 54 1: 5-22. doi:10.1556/AMicr.54.2007.1.2. PMID 17523388. ^ Alexander S, Ison CA 2007. Is New Variant Chlamydia trachomatis present in England and Wales?. Sexually Transmitted Infections 84: 29. doi:10.1136/sti.2007.026880. PMID 17855488. ^ Ortiz L, Angevine M, Kim SK, Watkins D, DeMars R 2000. T-cell epitopes in variable segments of Chlamydia trachomatis major outer membrane protein elicit serovar-specific immune responses in infected humans. Infect. Immun. 68 3: 1719-23. doi:10.1128/IAI.68.3.1719-1723.2000. PMID 10678996. External links Chlamydiae.com 1 342556674 at GPnotebook Retrieved from http://en..org/wiki/Chlamydia_trachomatis Categories: Chlamydiae Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Dansk Deutsch Español Français Bahasa Indonesia Italiano Nederlands 日本語 ‪Norsk bokmÃ¥l‬ Polski Português РуÑ?Ñ?кий Tiếng Việt Türkçe УкраїнÑ?ька This page was last modified on 20 June 2008, at 19:38

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