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07-SEPTEMBER-2008 03:17:44 - beta hydroxylase Redirected from Dopamine beta-hydroxylase Dopamine beta-hydroxylase dopamine beta-monooxygenase Identifiers Symbols DBH; DBM External IDs OMIM: 609312 MGI: 94864 HomoloGene: 615 EC number 1.14.17.1 Gene ontology Molecular function: monooxygenase activity dopamine beta-monooxygenase activity copper ion binding L-ascorbic acid binding metal ion binding Cellular component: extracellular region membrane fraction soluble fraction cytoplasm membrane chromaffin granule Biological process: cytokine production blood vessel remodeling response to amphetamine leukocyte mediated immunity histidine catabolic process synaptic transmission memory locomotory behavior associative learning visual learning regulation of cell proliferation homoiothermy dopamine catabolic process norepinephrine biosynthetic process glucose homeostasis fear response maternal behavior regulation of apoptosis positive regulation of vasoconstriction behavioral response to ethanol response to pain leukocyte migration RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 1621 13166 Ensembl ENSG00000123454 ENSMUSG00000000889 Uniprot P09172 Q3V1U4 Refseq NM_000787 mRNA NP_000778 protein NM_138942 mRNA NP_620392 protein Location Chr 9: 135.49 - 135.51 Mb Chr 2: 26.99 - 27 Mb Pubmed search 1 2 Dopamine β-hydroxylase DBH is an enzyme that converts dopamine to norepinephrine: Synonyms: Aromatic L-amino acid decarboxylase EC 4.1.1.28, tryptophan decarboxylase, 5-hydroxytryptophan decarboxylase, AAAD is a lyase enzyme. Dopamine Norepinephrine. Note extra hydroxyl group. DBH is a 290 kDa copper-containing oxygenase consisting of four identical subunits, and its activity requires ascorbate as a cofactor. 1 It is the only enzyme involved in the synthesis of small-molecule neurotransmitters that is membrane-bound, making norepinephrine and epinephrine the only transmitters synthesized inside vesicles. It is expressed in noradrenergic nerve terminals of the central and peripheral nervous systems, as well as in chromaffin cells of the adrenal medulla. DBH is inhibited by disulfiram, 2 tropolone, 3 and, most selectively, by nepicastat. 4 See also Hydroxylation References ^ Rush RA, Geffen LB 1980. Dopamine beta-hydroxylase in health and disease.. Crit Rev Clin Lab Sci. 12 3: 241-77. doi:10.3109/10408368009108731. PMID 6998654. ^ Goldstein M, Anagnoste B, Lauber E, McKeregham MR 1964. Inhibition of dopamine-beta-hydroxylase by Disulfiram.. Life Sci 3: 763-7. doi:10.1016/0024-32056490031-1. PMID 14203977. ^ Goldstein M, Lauber E, McKeregham MR 1964. Inhibition of dopamine-beta-hydroxylase by tropolone and other chelating agents.. Biochem Pharmacol 13: 1103-6. doi:10.1016/0006-29526490109-1. PMID 14201135. ^ Stanley WC et al. 1997. Catecholamine modulatory effects of nepicastat RS-25560-197, a novel, potent and selective inhibitor of dopamine-beta-hydroxylase.. British Journal of Pharmacology 121 8: 1803-9. doi:10.1038/sj.bjp.0701315. PMID 9283721. External links MeSH Dopamine+beta-Hydroxylase This oxidoreductase article is a stub. v d e Oxidoreductases: dioxygenases, including steroid hydroxylases EC 1.14 1.14.11 - 2-oxoglutarate Prolyl hydroxylase - Lysyl hydroxylase 1.14.13 - NADH or NADPH Flavin-containing monooxygenase - Nitric oxide synthase NOS1, NOS2A, NOS3 - Cholesterol 7 alpha-hydroxylase - Methane monooxygenase - 3A4 -51A1 1.14.14 - reduced flavin or flavoprotein 19A1 - 2D6 - 2E1 1.14.15 - reduced iron-sulfur protein 11B1 - 11B2 - 11A1 1.14.16 - reduced pteridine Phenylalanine hydroxylase - Tyrosine hydroxylase - Tryptophan hydroxylase 1.14.17 - reduced ascorbate Dopamine beta hydroxylase 1.14.18-19 - other Tyrosinase - Stearoyl-CoA desaturase-1 1.14.99 - miscellaneous Cyclooxygenase - Heme oxygenase HMOX1 - Squalene monooxygenase - 17A1 - 21A2 v d e Metabolism: amino acid metabolism - neurotransmitter enzymes histidine→histamine anabolism: Histidine decarboxylase catabolism: Histamine N-methyltransferase - Amine oxidase tyrosine→dopamine→epinephrine anabolism: Tyrosine hydroxylase - Aromatic L-amino acid decarboxylase - Dopamine beta hydroxylase - Phenylethanolamine N-methyltransferase catabolism: Catechol-O-methyl transferase - Monoamine oxidase glutamate→GABA anabolism: Glutamate decarboxylase catabolism: 4-aminobutyrate aminotransferase - 4-aminobutyrate transaminase tryptophan→serotonin→melatonin Tryptophan hydroxylase - Aromatic L-amino acid decarboxylase - Acetylserotonin O-methyltransferase arginine→NO Nitric oxide synthase NOS1, NOS2A, NOS3 choline→Acetylcholine anabolism: Choline acetyltransferase catabolism: Cholinesterase Acetylcholinesterase, Butyrylcholinesterase see also intermediates Retrieved from http://en..org/wiki/Dopamine_beta_hydroxylase Categories: Genes on chromosome 9 | Human proteins | Oxidoreductase stubsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 03:38
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