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07-SEPTEMBER-2008 03:17:44 - Endothelium Redirected from Endothelial Diagram showing the location of endothelial cells Diagram showing the location of endothelial cells This article is about the lining of blood vessels. For the endothelium of the cornea, see corneal endothelium The endothelium is the thin layer of cells that line the interior surface of blood vessels, forming an interface between circulating blood in the lumen and the rest of the vessel wall. Endothelial cells line the entire circulatory system, from the heart to the smallest capillary. These cells reduce turbulence of the flow of blood allowing the fluid to be pumped farther. Endothelial tissue is a specialized type of epithelium tissue one of the four types of biological tissue in animals. More specifically, it is simple squamous epithelium. Endothelium of the interior surfaces of the heart chambers are called endocardium. Both blood and lymphatic capillaries are composed of a single layer of endothelial cells. Contents 1 Function 2 Pathology 3 See also 4 External links 5 References Function Endothelial cells are involved in many aspects of vascular biology, including: vasoconstriction and vasodilation, and hence the control of blood pressure blood clotting thrombosis fibrinolysis atherosclerosis formation of new blood vessels angiogenesis inflammation and swelling oedema Endothelial cells also control the passage of materials - and the transit of white blood cells - into and out of the bloodstream. In some organs, there are highly differentiated endothelial cells to perform specialized 'filtering' functions. Examples of such unique endothelial structures include the renal glomerulus and the blood-brain barrier. Pathology Endothelial dysfunction, or the loss of proper endothelial function, is a hallmark for vascular diseases, and often leads to atherosclerosis. This is very common in patients with diabetes mellitus, hypertension or other chronic pathophysiological conditions. One of the main mechanisms of endothelial dysfunction is the diminishing of nitric oxide, often due to high levels of asymmetric dimethylarginine, which interfere with the normal L-arginine-stimulated nitric oxide synthesis. See also Endothelium-derived relaxing factor EDRF Robert F. Furchgott 1998 Nobel prize for discovery of EDRF Caveolae Weibel-Palade bodies Endothelial microparticles Endothelial progenitor cells Endocardium Tunica intima Apelin Susac's syndrome External links endothelium at eMedicine Dictionary Organology at UC Davis Circulatory/vessels/capillaries1/capillaries3 - Capillaries, non-fenestrated EM, Low Histology at BU 21402ooa Endothelium: Journal of Endothelial Research 1 References Molecular Biology of the CELL, 4th ion, Alberts et al., 2002 v d e Cardiovascular system Systemic circulation Heart → Aorta → Arteries → Arterioles → Capillaries → Venules → Veins → Vena cava → Heart Pulmonary circulation Heart → Pulmonary arteries → Lungs → Pulmonary vein → Heart Blood vessels Endothelium - Tunica intima - Tunica media - Tunica externa Retrieved from http://en..org/wiki/Endothelium Categories: Cardiovascular system | Tissues Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages БългарÑ?ки Català Deutsch Español Esperanto Français Italiano Latina Nederlands 日本語 Plattdüütsch Polski Português СрпÑ?ки / Srpski Svenska Suomi УкраїнÑ?ька Tiếng Việt 䏿–‡ This page was last modified on 10 August 2008, at 00:26
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