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News About Familial_amyloid_neuropathy

07-SEPTEMBER-2008 03:17:44 - amyloid neuropathy Familial amyloid neuropathy Classification and external resources ICD-10 E85.1 ICD-9 277.3 MeSH D028227 The familial amyloid neuropathies or familial amyloidotic neuropathies, neuropathic heredofamilial amyloidosis, familial amyloid polyneuropathy are a rare group of autosomal dominant neuropathies of autonomic and peripheral nerves. Contents 1 Classification 2 Treatment 3 References 4 External links Classification The precursor proteins are: transthyretin ATTR, the most commonly implicated protein, apolipoprotein A1, and gelsolin. Due to the rareness of the other types, it is sometimes associated with transthyretin alone.1 FAP-I and FAP-II are associated with transthyretin.2 Senile systemic amyloidosis is also associated with transthyretin. FAP-III is also known as Iowa-type, and involves apolipoprotein A1.2 FAP-IV is also known as Finnish-type, and involves gelsolin.3 Fibrinogen, apolipoprotein A1, and lysozyme are associated with a closely related condition, familial visceral amyloidosis. Treatment Liver transplantation has demonstrated moderate improvement in ATTR familial amyloidosis.4 References ^ Delahaye N, Rouzet F, Sarda L, et al July 2006. Impact of liver transplantation on cardiac autonomic denervation in familial amyloid polyneuropathy. Medicine Baltimore 85 4: 229-38. doi:10.1097/01.md.0000232559.22098.c3. PMID 16862048. ^ a b Amyloid. ^ Akiya S, Nishio Y, Ibi K, et al July 1996. Lattice corneal dystrophy type II associated with familial amyloid polyneuropathy type IV. Ophthalmology 103 7: 1106-10. PMID 8684801. ^ BU. External links http://cancerweb.ncl.ac.uk/cgi-bin/omd?herary+amyloidosis v d e Metabolic disease: amyloidosis E85, 277.3 Forms of amyloid Serum amyloid P component - Serum amyloid A - Transthyretin - Beta-2 microglobulin - Bence Jones protein/Multiple myeloma - Amyloid precursor protein/Beta amyloid - Amylin Systemic amyloidosis AL amyloidosis - AA amyloidosis - Haemodialysis-associated amyloidosis - Senile systemic amyloidosis - Finnish type amyloidosis - Familial Merranean fever Organ-limited amyloidosis heart: Cardiac amyloidosis brain: Familial amyloid neuropathy - Cerebral amyloid angiopathy - Alzheimer's disease kidney: Familial renal amyloidosis cutaneous: Primary cutaneous amyloidosis Retrieved from http://en..org/wiki/Familial_amyloid_neuropathy Categories: Metabolic disorders | Diseases Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 24 June 2008, at 14:29

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