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Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
07-SEPTEMBER-2008 03:17:44 - Fosinopril Fosinopril Systematic IUPAC name 4-cyclohexyl-1-2-2-methyl-1-propanoyloxy-propoxy-4-phenylbutylphosphorylacetyl -pyrrolidine-2-carboxylic acid Diagrams above are fosinopril and fosinoprilat, respectively. Data below refers to fosinopril unless indicated Identifiers CAS number 98048-97-6 ATC code C09AA09 PubChem 55891 DrugBank APRD00526 Chemical data Formula C30H46NO7P Mol. mass 563.663 g/mol Pharmacokinetic data Bioavailability ~36% Protein binding 87% fosinoprilat Metabolism hepatic, GIT mucosa to fosinoprilat Half life 12 hours fosinoprilat Excretion renal Therapeutic considerations Pregnancy cat. DAU Legal status ℞ Prescription only Routes oral Fosinopril is an angiotensin converting enzyme ACE inhibitor used for the treatment of hypertension and some types of chronic heart failure. Fosinopril is the first and only phosphonate-containing ACE inhibitor marketed. It is marketed by Bristol-Myers Squibb under the trade name Monopril. Development The development of fosinopril started from the observation of the hypotensive effects of phosphoramidon, an extract from the bacterium Streptomyces tanashiensis. Phosphoramidon was found to be a potent inhibitor of ACE. It was speculated that the phosphoramide moiety in the molecule was central to its inhibition of ACE. Further studies found that the phosphoramide moiety served the dual-purpose of interacting with the Zn2+ in ACE, as well as mimicking the transition-state of the natural substrate of ACE. These discoveries led to the attempt to develop a new group of ACE inhibitors which contained the phosphoramide moiety. The initial lead proved to be very potent but unstable at physiological pH. Later compounds would have a phosphonate moiety being more stable in place of the phosphoramide. The lessons learnt in the development of enalapril and later ACE inhibitors were applied to the design and eventually fosinoprilat was developed. Fosinoprilat and Fosinopril Fosinoprilat proved to have the same problem as enalaprilat and the other carboxylate-containing ACE inhibitors namely poor oral bioavailability. The solution, fortunately, was very similar - the addition of a hydrophobic side-chain to modulate the ionisation characteristics of the molecule. Thus fosinopril was developed. Fosinopril is administered as a prodrug and is converted in vivo to the active form fosinoprilat. v d e Agents acting on the renin-angiotensin system C09 ACE inhibitors Alacepril Benazepril Captopril Cilazapril Delapril Enalapril Fosinopril Imidapril Lisinopril Moexipril Perindopril Quinapril Ramipril Rentiapril Spirapril Temocapril Trandolapril Zofenopril Angiotensin II receptor antagonists AIIRA Azilsartan Candesartan Eprosartan Irbesartan Losartan Olmesartan Tasosartan Telmisartan Valsartan Renin inhibitors Aliskiren Remikiren Retrieved from http://en..org/wiki/Fosinopril Categories: ACE inhibitors Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages العربية Deutsch Hrvatski Italiano Magyar This page was last modified on 7 August 2008, at 23:21
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So many of us do not eat a balanced diet, get enough sleep, have too much stress, or are impacted with toxins and pollutants. Drinking 2 ounces of MonaVie twice a day will help your body detoxify as well as build your immune system. Its the smartest thing you can do for yourself, so start today. Buying MonaVie through our company guarantees you support 7 days a week and, if you would like to share MonaVie with your family and friends we will guide you from start to finish.
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