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07-SEPTEMBER-2008 03:17:44 - Gamma globulin Redirected from Gammopathy June 2007 Schematic representation of a protein electrophoresis gel Schematic representation of a protein electrophoresis gel Gamma globulins, or Ig's, are a class of proteins in the blood, identified by their position after serum protein electrophoresis. The most significant gamma globulins are immunoglobulins. Contents 1 Injections 2 Pathology 3 Disease treatments 4 External links Injections Gamma globulin injections are usually given in an attempt to temporarily boost a patient's immunity against disease. Injections are most commonly used on patients who have been exposed to hepatitis A or measles, or to make a donor and a kidney recipient compatible regardless of blood type of tissue match. Injections are also used to boost immunity in patients who cannot produce gamma globulins naturally because of an immune deficiency, such as X-linked agammaglobulinemia and hyper IgM syndrome. Such injections are less common in modern medical practice than they were previously, and injections of gamma globulin previously recommended for travelers have largely been replaced by the use of hepatitis A vaccine. Gamma globulin infusions are also used to treat immunological diseases, such as idiopathic thrombocytopenia purpura ITP, a disease in which the platelets are being attacked by antibodies, leading to seriously low platelet counts. Gamma globulin apparently causes the spleen to ignore the antibody-tagged platelets, thus allowing them to survive and function. Gamma globulin injections also provide substantial benefit to many suffering from Chronic Fatigue Syndrome, also known as Chronic Fatigue and Immune Disfunction Syndrome; Mylagic Encyphalitis; Chronic Epsteinn-Barr; Chronic Mono. In particular, it helps those who are greatly affected by changes in the barometric pressure i.e., change in weather conditions, especially rain or other storms. Another theory on how gamma globulin administration works in autoimmune disease is by overloading the mechanisms which degrade gamma globulins. Overloading the degradation mechanism causes the harmful gamma globulins to have a much shorter halflife in sera. Pathology An excess is known as hypergammaglobulinemia. A disease of gamma globulins is called a gammopathy for example, in monoclonal gammopathy of undetermined significance. Disease treatments Kawasaki disease Kidney Transplant: Intravenous Gamma globulin was FDA approved in 2004 to reduce antibodies in a patient with kidney failure to allow that person to accept a kidney from a donor who has a different blood type, ABO incompatible or is an unacceptable tissue match. Dr. Stanley Jordan at Cedars-Sinai Medical Center in Los Angeles pioneered this treatment. External links MeSH gamma-Globulins http://www.sciencedaily.com/releases/2004/12/041208234532.htm v d e Proteins: globulins Serum Alpha globulins - Beta globulins - Gamma globulin Immunoglobulins - Fibronectins - Macroglobulins - Transcobalamins Other Beta-lactoglobulin Lactoferrin - Thyroglobulin - Alpha-lactalbumin This medical article is a stub. This protein-related article is a stub. Retrieved from http://en..org/wiki/Gamma_globulin Categories: Proteins | Medicine stubs | Protein stubsHidden categories: Articles lacking sources from June 2007 | All articles lacking sources Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Deutsch Português Suomi This page was last modified on 6 August 2008, at 22:37
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