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07-SEPTEMBER-2008 03:17:44 - Immunoglobulin light chain Schematic diagram of an typical antibody showing two Ig heavy chains blue linked by disulfide bonds to two Ig light chains green. The constant C and variable V domains are shown. Schematic diagram of an typical antibody showing two Ig heavy chains blue linked by disulfide bonds to two Ig light chains green. The constant C and variable V domains are shown. An antibody molecule. The two heavy chains are colored red and blue and the two light chains green and yellow. See also:1 An antibody molecule. The two heavy chains are colored red and blue and the two light chains green and yellow. See also:1 A light chain is the small polypeptide subunit of an antibody or immunoglobulin. A typical antibody is composed of two immunoglobulin Ig heavy chains and two Ig light chains. Contents 1 In humans 2 In other animals 3 Structure 4 References 5 External links In humans There are two types of light chain in mammals, lambda λ chain 1, 2, 3, and 4 kappa κ chain only one type In other animals Other types of light chains can be found in lower vertebrates, such as the Ig-Light-Iota chain of Chondrichthyes and Teleostei.12 Camelids are unique among mammals as they have fully functional antibodies which have two heavy chains, but lack the light chains usually paired with each heavy chain.3 The functional role of this separate repertoire is unknown as yet. Structure Only one type of light chain is present in a typical antibody, thus the two light chains of an individual antibody are identical. Each light chain is composed of two tandem immunoglobulin domains: one constant IgC domain one variable domain IgV that is important for binding antigen The approximate length of a light chain protein is from 211 to 217 amino acids.1 References ^ a b Janeway CA, Jr. et al 2001. Immunobiology., 5th ed., Garland Publishing. electronic full text via NCBI Bookshelf ISBN 0-8153-3642-X. ^ IMGT Index Antibodies or Immunoglobulins. ^ Hamers-Casterman C, Atarhouch T, Muyldermans S, Robinson G, Hamers C, Songa E, Bendahman N, Hamers R 1993. Naturally occurring antibodies devoid of light chains. Nature 363 6428: 446-8. PMID 8502296. External links MeSH Immunoglobulin+Light+Chains v d e Immune system proteins Antibodies Light chain, Heavy chain, IgA, IgD, IgE, IgG, IgM Other MAC complex - Nanobodies - Perforin This protein-related article is a stub. Retrieved from http://en..org/wiki/Immunoglobulin_light_chain Categories: Immune system | Protein stubs Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Español This page was last modified on 22 July 2008, at 18:33
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