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07-SEPTEMBER-2008 03:17:44 - Lipodystrophy Lipodystrophy Classification and external resources ICD-10 E88.1 ICD-9 272.6 DiseasesDB 30066 eMedicine med/1307 med/3523 MeSH D008060 Lipodystrophy is a medical condition characterized by abnormal or degenerative conditions of the body's adipose tissue. Lipo is Greek for fat and dystrophy is Greek for abnormal or degenerative condition. A more specific term, lipoatrophy is used when describing the loss of fat from one area usually the face. Contents 1 Insulin injections 2 Antiretroviral drugs 3 Herary forms 4 References 5 See also 6 External links Insulin injections A lipodystrophy can be a lump or small dent in the skin that forms when a person keeps performing injections in the same spot. These types of lipodystrophies are harmless. People who want to avoid them can do so by changing rotating the places where they perform injections. For people with diabetes, using purified insulins may also help. One of the side-effects of lipodystrophy is the rejection of the injected medication, the slowing down of the absorption of the medication, or trauma that can cause bleeding that, in turn, will reject the medication. In either scenarios, the dosage of the medication, such as insulin for diabetics, becomes impossible to gauge correctly and the treatment of the disease for which the medication is administered is impaired thereby allowing the medical condition to worsen. In some cases, rotation of the injection sites may not be enough to prevent lipodystrophy. Antiretroviral drugs Lipodystrophies can be a possible side effect of antiretroviral drugs. Other lipodystrophies manifest as lipid redistribution; with excess, or lack of, fat in various regions of the body. These include, but are not limited to, having sunken cheeks and/or humps on the back or back of the neck also referred to as buffalo hump.1 Herary forms Lipodystrophy can be caused by metabolic abnormalities due to genetic issues. These are often characterized by insulin resistance and are associated with Syndrome X. References ^ Physical and Biochemical Changes in HIV Disease Eric S. Daar, M.D. MedicineNet, Accessed 22 September 2007 See also Barraquer-Simons syndrome External links DermAtlas 1847886158 TheBody: The Lipoatrophy Resource Center v d e Lipid metabolism disorders / Inborn error of lipid metabolism - dyslipidemia E78 and E71.3, 272 Hyperlipidemia Hypercholesterolemia/Hypertriglyceridemia Familial hypercholesterolemia, Combined hyperlipidemia - Xanthoma Hypolipoproteinemia Hypoalphalipoproteinemia/HDL Lecithin cholesterol acyltransferase deficiency, Tangier disease Hypobetalipoproteinemia/LDL Abetalipoproteinemia, Apolipoprotein B deficiency Lipodystrophy Barraquer-Simons syndrome Fatty acid metabolism deficiency transport: Carnitine Primary, I, II, -acylcarnitine - Adrenoleukodystrophy beta oxidation: Acyl CoA dehydrogenase Short-chain, Medium-chain, Long-chain 3-hydroxy, Very long-chain - Mitochondrial trifunctional protein deficiency to acetyl-CoA: Malonic aciduria Cholesterol synthesis Smith-Lemli-Opitz syndrome Other Sjögren-Larsson syndrome - Lipomatosis - Adiposis dolorosa - Lipoid proteinosis see also lipid metabolism enzymes, lipoprotein metabolism This medical sign article is a stub. Retrieved from http://en..org/wiki/Lipodystrophy Categories: Metabolic disorders | Medical sign stubs Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Deutsch Español Bahasa Indonesia Italiano Nederlands Polski This page was last modified on 25 May 2008, at 22
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