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07-SEPTEMBER-2008 03:17:44 - Melphalan Melphalan Systematic IUPAC name 2-amino-3-4-bis2-chloroethylaminophenyl- propanoic acid Identifiers CAS number 148-82-3 ATC code L01AA03 PubChem 4053 DrugBank APRD00118 Chemical data Formula C13H18Cl2N2O2 Mol. mass 305.2 g/mol Pharmacokinetic data Bioavailability 25% to 89% Metabolism hydrolysis Half life 1.5 ± 0.8 hours Excretion Renal, significantly metabolised Therapeutic considerations Pregnancy cat. ? Legal status ℞ Prescription only Routes Oral, intravenous Melphalan hydrochloride trade name Alkeran is a chemotherapy drug belonging to the class of nitrogen mustard alkylating agents. It is used primarily to treat multiple myeloma and ovarian cancer, and occasionally malignant melanoma. Otherwise known as L-Phenylalanine Mustard, or L-PAM, melphalan is a phenylalanine derivative of mechlorethamine. The agent was first investigated as a possible drug for use in melanoma. It did not work, but was found to be of use in myeloma. Administration Oral or intravenous; dosing varies by purpose and route of administration as well as patient weight. Side effects Common side effects include: Nausea and vomiting Bone marrow suppression, including Decreased white blood cell count causing increased risk of infection Decreased platelet count causing increased risk of bleeding Less common side effects include: Severe allergic reactions Scarring of lung tissue usually only with prolonged use Hair loss Rash Itching Tablets This pharmacology-related article is a stub. v d e Chemotherapeutic agents/Antineoplastic agents L01 Purine+pyrimidine/ Ribonucleotides/ Deoxyribonucleotides Antimetabolites Folic acid: Aminopterin, Methotrexate, Pemetrexed, Raltitrexed Purine: Cladribine, Clofarabine, Fludarabine, Mercaptopurine, Pentostatin, Thioguanine Pyrimidine: Cytarabine, Decitabine, Fluorouracil/Capecitabine, Floxuridine, Gemcitabine, Enocitabine, Sapacitabine DNA Alkylating/alkylating-like Nitrogen mustards: Chlorambucil, Chlormethine, Cyclophosphamide, Ifosfamide, Melphalan, Bendamustine, Trofosfamide, Uramustine Nitrosoureas:Carmustine, Fotemustine, Lomustine, Nimustine, Prednimustine, Ranimustine, Semustine, Streptozocin Platinum alkylating-like: Carboplatin, Cisplatin, Nedaplatin, Oxaliplatin, Triplatin tetranitrate, Satraplatin Alkyl sulfonates:Busulfan, Mannosulfan, Treosulfan Hydrazines:Procarbazine Triazenes:Dacarbazine, Temozolomide Aziridines:Carboquone, ThioTEPA, Triaziquone, Triethylenemelamine Spindle poison/mitotic inhibitor Taxane: Docetaxel, Larotaxel, Ortataxel, Paclitaxel, Tesetaxel. Vinca: Vinblastine, Vincristine, Vinflunine, Vindesine, Vinorelbine, Ixabepilone Cytotoxic/antitumor antibiotics Anthracycline family: Aclarubicin, Daunorubicin, Doxorubicin, Epirubicin, Idarubicin, Amrubicin, Pirarubicin, Mitoxantrone, Pixantrone, Valrubicin, Zorubicin streptomyces Actinomycin, Bleomycin, Mitomycin, Plicamycin - Hydroxyurea Topoisomerase inhibitors Camptotheca: Camptothecin, Topotecan, Irinotecan, Rubitecan, Belotecan, Podophyllum:Etoposide, Teniposide Other Altretamine, Amsacrine, Bexarotene, Estramustine, Irofulven, Trabectedin Cellular CI monoclonal antibodies Receptor tyrosine kinase Cetuximab, Panitumumab, Trastuzumab - CD20 Rituximab, Tositumomab - other Alemtuzumab, Bevacizumab, Edrecolomab, Gemtuzumab Tyrosine kinase inhibitors Axitinib, Bosutinib, Cediranib, Dasatinib, Erlotinib, Gefitinib, Imatinib, Lapatinib, Lestaurtinib, Nilotinib, Semaxanib, Sorafenib, Sunitinib, Vandetanib Cyclin-dependent kinase inhibitors Alvocidib, Seliciclib Other Fusion protein Aflibercept, Denileukin diftitox Other/ungrouped Photosensitizers Aminolevulinic acid, Efaproxiral, Methyl aminolevulinate, Porfimer sodium, Talaporfin, Temoporfin, Verteporfin Other retinoids Alitretinoin, Tretinoin, Anagrelide, Arsenic trioxide, Asparaginase Pegaspargase, Atrasentan, Bortezomib, Carmofur, Celecoxib, Demecolcine, Elesclomol, Elsamitrucin, Etoglucid, Lonidamine, Lucanthone, Masoprocol, Mitobronitol, Mitoguazone, Mitotane, Oblimersen, Omacetaxine, Sitimagene ceradenovec, Tegafur, Testolactone, Tiazofurine, Tipifarnib, Vorinostat Retrieved from http://en..org/wiki/Melphalan Categories: Chemotherapeutic agents | Pharmacology stubs Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages 日本語 Polski This page was last modified on 19 July 2007, at 17:42
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