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07-SEPTEMBER-2008 03:17:44 - Nephropathy April 2008 Nephropathy Classification and external resources MeSH D007674 Nephropathy refers to damage to or disease of the kidney. An older term for this is nephrosis. Contents 1 Causes 1.1 Analgesics 1.2 Xanthine oxidase deficiency 2 See also Causes or section by expanding it. Further information might be found on the talk page or at requests for expansion. June 2008 The main causes of nephropathy are administration of analgesics, xanthine oxidase deficiency, and long-term exposure to lead or its salts. Analgesics One cause of nephropathy is the long term usage of analgesics. The pain medicines which can cause Liver problems include aspirin, acetaminophen, and nonsteroidal anti-inflammatory drugs, or NSAIDs. This form of nephropathy is chronic analgesic nephritis, a chronic inflammatory change characterized by loss and atrophy of tubules and interstitial fibrosis and inflammation BRS Pathology, 2nd ion. Specifically, long term use of the analgesic phenacetin has been linked to renal papillary necrosis necrotizing papillitis. Xanthine oxidase deficiency A second possible cause of nephropathy is due to decreased function of xanthine oxidase in the purine degradation pathway. Xanthine oxidase will degrade hypoxanthine to xanthine and then to uric acid. Xanthine is not very soluble in water; therefore, an increase in xanthine forms crystals which can lead to kidney stones and result in damage of the kidney. Drugs like allopurinol that are used to inhibit xanthine oxidase can therefore cause possible nephropathy. See also Diabetic nephropathy Hypertensive nephropathy Nephritis IgA nephropathy This medical article is a stub. v d e Urinary system - Pathology - Urologic disease N00-N39, 580-599 Abdominal Kidney/ nephropathy Glomerulus Nephritis/ glomerulonephritis by structure: Membranoproliferative glomerulonephritis - Membranous glomerulonephritis/Membranous nephritis - IgA nephropathy/glomerulonephritis by disease: Post-streptococcal glomerulonephritis - Lupus nephritis other: Rapidly progressive glomerulonephritis - Nephritic syndrome Nephrosis/ noninflammatory Glomerulosclerosis Focal segmental glomerulosclerosis, Diabetic nephropathy/glomerulosclerosis - Nephrotic syndrome Minimal change disease - Familial renal amyloidosis Tubulointerstitial/ Renal tubule Interstitial nephritis Pyelonephritis, Danubian endemic familial nephropathy Uropathy Obstructive uropathy, Hydronephrosis, Pyonephrosis Inborn errors of renal tubular transport Renal tubular acidosis, Gitelman syndrome Reflux nephropathy - Nephrogenic diabetes insipidus - Renal papillary necrosis Renal failure Acute renal failure Acute tubular necrosis - Chronic renal failure Other Renal osteodystrophy - Nephroptosis - Abderhalden-Kaufmann-Lignac syndrome vascular Renal artery stenosis, Hypertensive nephropathy, Renovascular hypertension Ureter Ureteritis - Ureterocele - Megaureter Pelvic Bladder Cystitis Interstitial cystitis, Trigonitis - Neurogenic bladder - Vesicointestinal fistula - Vesicoureteral reflux Urethra Urethritis Non-gonococcal urethritis - Urethral syndrome - Urethral stricture Other/general Urinary tract infection - Retroperitoneal fibrosis - Urolithiasis Kidney stone, Renal colic See also congenital, neoplasia, symptoms/signs Retrieved from http://en..org/wiki/Nephropathy Categories: Kidney diseases | Organ disorders | Medicine stubsHidden categories: Articles lacking sources from April 2008 | All articles lacking sources | Articles to be expanded since June 2008 | All articles to be expanded Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Deutsch Español Português Suomi Svenska This page was last modified on 18 August 2008, at 19:40
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