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07-SEPTEMBER-2008 03:17:44 - Organ-limited amyloidosis Organ-limited amyloidosis Classification and external resources ICD-10 E85.4 ICD-9 277.3 Organ-limited amyloidosis is a category of amyloidosis where the distribution can be associated primarily with a single organ. It is contrasted to systemic amyloidosis, and it can be caused by several different types of amyloid.1 In almost all of the organ-specific pathologies, there is significant debate as to whether the amyloid plaques are the causal agent of the disease or instead a downstream consequence of a common idiopathic agent. The associated proteins are indicated in parentheses. Contents 1 Neurological amyloid 2 Cardiovascular amyloid 3 Other 4 References Neurological amyloid Alzheimer's disease Aβ 39-43 Parkinson's disease alpha-synuclein Huntington's disease huntingtin protein Transmissible spongiform encephalopathies caused by prion protein PrP were sometimes classed as amyloidoses, as one of the four pathological features in diseased tissue is the presence of amyloid plaques. These diseases include; Creutzfeldt-Jakob disease PrP in cerebrum Kuru diffuse PrP deposits in brain Fatal Familial Insomnia PrP in thalamus Bovine spongiform encephalopathy PrP in cerebrum of cows Cardiovascular amyloid Cardiac amyloidosis Senile cardiac amyloidosis-may cause heart failure Congophilic angiopathy Other Amylin deposition can occur in the pancreas in some cases of type 2 diabetes mellitus References ^ Mayo Clinic Proceedings. v d e Metabolic disease: amyloidosis E85, 277.3 Forms of amyloid Serum amyloid P component - Serum amyloid A - Transthyretin - Beta-2 microglobulin - Bence Jones protein/Multiple myeloma - Amyloid precursor protein/Beta amyloid - Amylin Systemic amyloidosis AL amyloidosis - AA amyloidosis - Haemodialysis-associated amyloidosis - Senile systemic amyloidosis - Finnish type amyloidosis - Familial Merranean fever Organ-limited amyloidosis heart: Cardiac amyloidosis brain: Familial amyloid neuropathy - Cerebral amyloid angiopathy - Alzheimer's disease kidney: Familial renal amyloidosis cutaneous: Primary cutaneous amyloidosis Retrieved from http://en..org/wiki/Organ-limited_amyloidosis Categories: Metabolic disorders | Diseases Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 24 June 2008, at 13:30

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