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07-SEPTEMBER-2008 03:17:44 - ejaculation Semi-protected This article or section has multiple issues. Please help improve the article or discuss these issues on the talk page. It may contain original research or claims. Tagged since March 2008. It is in need of attention from an expert on the subject. Medicine or the Medicine Portal may be able to help recruit one. It may need a complete rewrite to meet 's quality standards.Tagged since April 2008. Premature ejaculation Classification and external resources ICD-10 F52.4 ICD-9 302.75 MedlinePlus 001524 eMedicine med/643 Premature ejaculation PE, also known as, rapid ejaculation, rapid climax, premature climax or early ejaculation, is the most common sexual problem in men, affecting 25%-40% of men. It is characterized by a lack of voluntary control over ejaculation. Masters and Johnson stated that a man suffers from premature ejaculation if he ejaculates before his sex partner achieves orgasm in more than fifty percent of their sexual encounters. Other sex researchers have defined premature ejaculation as occurring if the man ejaculates within two minutes of penetration; however, a survey by Alfred Kinsey in the 1950s demonstrated that three quarters of men ejaculate within two minutes of penetration in over half of their sexual encounters. Today, most sex therapists understand premature ejaculation as occurring when a lack of ejaculatory control interferes with sexual or emotional well-being in one or both partners. The term premature ejaculation is not well defined in medical circles and is sometimes considered to be more of a marketing tool than a medical condition. By widely advertising PE/ED as a problem, an industry has been created to solve what was in the past not a great concern. This process is analagous to the 'invention' of halitosis for the purpose of Listerine sales. The psychological effects of PE/ED have also been considered similar to the effects on young women of the thin model paradigm. Most men experience premature ejaculation at least once in their lives. Often adolescents and young men experience premature ejaculation during their first sexual encounters, but eventually learn ejaculatory control. Because there is great variability in both how long it takes men to ejaculate and how long both partners want sex to last, researchers have begun to form a quantitative definition of premature ejaculation. Current evidence supports an average intravaginal ejaculation latency time IELT of six and a half minutes in 18-30 year olds.12 If the disorder is defined as an IELT percentile below 2.5, then premature ejaculation could be suggested by an IELT of less than about one and a half minutes.3 Nevertheless, it is well accepted that men with IELTs below 1.5 minutes could be happy with their performance and do not report a lack of control and therefore do not suffer from PE. On the other hand, a man with 2 minutes IELT could present with perception of poor control over his ejaculation, distressed about his condition, has interpersonal difficulties and therefore be diagnosed with PE. Contents 1 Possible psychological and environmental factors 2 Possible physical factors 2.1 Science of mechanism of ejaculation 3 Diagnosis 3.1 Differential diagnosis 3.2 Ejaculation disorder types 4 Treatment 4.1 Medications 4.2 Devices 5 References Possible psychological and environmental factors Psychological factors commonly contribute to premature ejaculation. While men sometimes underestimate the relationship between sexual performance and emotional well-beingwho?, premature ejaculation can be caused by temporary depression, stress over financial matters, unrealistic expectations about performance, a history of sexual repression, or an overall lack of confidence. Interpersonal dynamics strongly contribute to sexual function, and premature ejaculation can be caused by a lack of communication between partners, hurt feelings, or unresolved conflicts that interfere with the ability to achieve emotional intimacy. Neurological premature ejaculation can also lead to other forms of sexual dysfunction, or intensify the existing problem, by creating performance anxiety. In a less pathological context, premature ejaculation could also be simply caused by extreme arousal. Recent research has also investigated the role of factors involving the female partner. One study of young married couples Tullberg, 1999 reported that the husband's IELT seems to be affected by the phases of the wife's menstrual cycle, the IELT tending to be shortest during the fertile phase. Other studies suggest that young men with older female partners reach the ejaculatory threshold sooner, on average, than those whose partners are their own age or youngercitation needed. Possible physical factors Science of mechanism of ejaculation The physical process of ejaculation requires two sequential actions: emission and expulsion. Mechanism of Ejaculation Mechanism of Ejaculation The emission phase is the first one to happen and it involves deposition of seminal fluid from ampullary vasa deferens, seminal vesicles prostate gland into posterior urethra.4 Second phase is the expulsion of semen which involves closure of bladder neck followed by the rhythmic contractions of urethra by pelvic-perineal and bulbospongiosus muscle and intermittent relaxation of external Sphincter urethrae.5 Today it is believed that the neurotransmitor serotonin 5HT has a central role in modulating ejaculation. Several animal studies have demonstrated its inhibitory effect on ejaculation modulated through the PGI system in the brain. Therefore, it is perceived that low level of serotonin in the synaptic cleft in these specific areas in the brain could cause premature ejaculation. This theory is further supported by the proven effectiveness of SSRIs, which increase serotonin level in the synapse, in treating PE. Sympathetic motor neurons control the emission phase of ejaculation reflex and expulsion phase is executed by somatic and autonomic motor neurons. These motor neurons are located in the thoracolumbar and lumbosacral spinal cord and are activated in a coordinated manner when sufficient sensory input to reach the ejaculatory threshold has entered the central nervous system.67 Several areas in the brain, and especially the nucleus paragigantocellularis, have been identified to be involved in ejaculatory control.8 Scientists have long suspected a genetic link to certain forms of premature ejaculation. In one study, ninety-one percent of men who suffered from lifelong premature ejaculation also had a first-relative with lifelong premature ejaculation. Other researchers have noted that men who suffer from premature ejaculation have a faster neurological response in the pelvic muscles. Simple exercises commonly suggested by sex therapists can significantly improve ejaculatory control for men with premature ejaculation caused by neurological factorscitation needed. Often, these men may benefit from anti-anxiety medication or selective serotonin reuptake inhibitors SSRIs, such as sertraline or paroxetine, as these slow down ejaculation times1. Some men prefer using anaesthetic creams, however, these creams may also deaden sensations in the man's partner, and are not generally recommended by sex therapists. Diagnosis Diagnostic criteria for Premature Ejaculation DSM-IV-TR American Psychiatric Association A. Persistent or recurrent ejaculation with minimal sexual stimulation before, on, or shortly after penetration and before the person wishes it. The clinician must take into account factors that affect duration of the excitement phase, such as age, novelty of the sexual partner or situation, and recent frequency of sexual activity. B. The disturbance causes marked distress or interpersonal difficulty. C. The premature ejaculation is not due exclusively to the direct effects of a substance e.g., withdrawal from opioids. Differential diagnosis Premature ejaculation should be distinguished from erectile dysfunction related to the development of a general medical condition. Some individuals with erectile dysfunction may omit their usual strategies for delaying orgasm. Others require prolonged noncoital stimulation to develop a degree of erection sufficient for intromission. In such individuals, sexual arousal may be so high that ejaculation occurs immediately. Occasional problems with premature ejaculation that are not persistent or recurrent or are not accompanied by marked distress or interpersonal difficulty do not qualify for the diagnosis of premature ejaculation. The clinician should also take into account the individual's age, overall sexual experience, recent sexual activity, and the novelty of the partner. When problems with premature ejaculation are due exclusively to substance use e.g., opioid withdrawal, a substance-induced sexual dysfunction can be diagnosed. Ejaculation disorder types Premature ejaculation -Ejaculation occurs very early Retarded ejaculation -Ejaculation takes a long time Retrograde ejaculation -Semen flows from the prostate gland into the bladder rather than spurting out of the penis Inhibited orgasm in males9 Treatment This section contains instructions, advice, or how-to content. The purpose of is to present facts, not to teach subject matter. by removing or rewriting the how-to content, which may qualify for a move to Wikiversity, http://www.wikihow.com/, or http://howto.wikia.com/. In mundane cases, treatments are focused on gradually training and improving mental habituation to sex and physical development of stimulation control. In clinical cases, various medications are being tested to help slow down the speed of the arousal response. Masters and Johnson recommended a start and stop technique to increase the time till ejaculation. This requires a great deal of couple cooperation and communication and may be difficult for some. Medications Serotonergic medications, such as SSRIs can delay ejaculation.1011 SSRIs are commonly used as anti-depressants. Examples include Prozac, Zoloft, Celexa, Effexor, and Lexapro. William Francis Ganong physiologist, cited dietary 5-HTP as an alternative source to raising serotonin levels. Many supplements are available that contain 5-HTP. Devices External latex rigid sheathes fastened to the body have been developed that cover all part of the penis during penetration so that the penis is protected from all the stimulation of the vagina. These help to gain control and to provide satisfaction to the partner. Masters and Johnson recommended the use of the Lateral coital position to help alleviate premature ejaculation. References ^ Ejaculation delay: what's normal? July 2005; 137-4. Retrieved on 2007-10-21. ^ Waldinger MD, Quinn P, Dilleen M, Mundayat R, Schweitzer DH, Boolell M 2005. A multinational population survey of intravaginal ejaculation latency time. The journal of sexual medicine 2 4: 492-7. doi:10.1111/j.1743-6109.2005.00070.x. PMID 16422843. ^ Waldinger MD, Zwinderman AH, Olivier B, Schweitzer DH 2005. Proposal for a definition of lifelong premature ejaculation based on epidemiological stopwatch data. The journal of sexual medicine 2 4: 498-507. doi:10.1111/j.1743-6109.2005.00069.x. PMID 16422844. ^ Böhlen D, Hugonnet CL, Mills RD, Weise ES, Schmid HP 2000. Five meters of H2O: the pressure at the urinary bladder neck during human ejaculation. Prostate 44 4: 339-41. doi:10.1002/1097-00452000090144:4339::AID-PROS123.0.CO;2-Z. PMID 10951500. ^ Master VA, Turek PJ 2001. Ejaculatory physiology and dysfunction. Urol. Clin. North Am. 28 2: 363-75, x. doi:10.1016/S0094-01430570145-2. PMID 11402588. ^ deGroat WC, Booth AM 1980. Physiology of male sexual function. Ann. Intern. Med. 92 2 Pt 2: 329-31. PMID 7356224. ^ Truitt WA, Coolen LM 2002. Identification of a potential ejaculation generator in the spinal cord. Science 297 5586: 1566-9. doi:10.1126/science.1073885. PMID 12202834. ^ Coolen LM, Olivier B, Peters HJ, Veening JG 1997. Demonstration of ejaculation-induced neural activity in the male rat brain using 5-HT1A agonist 8-OH-DPAT. Physiol. Behav. 62 4: 881-91. PMID 9284512. ^ Premature Ejaculation. Premature Ejaculation and Male Orgasmic Disorder. Armenian Medical Network 2006. Retrieved on 2007-09-19. ^ Safarinejad, M. R., Hosseini, S. Y. 2006. Pharmacotherapy for premature ejaculation. Current Drug Therapy, 1, 37-46. ^ SadeghiNejad, H., Watson, R. 2008. Premature ejaculation: Current medical treatment and new directions. Journal of Sexual Medicine, 5, 1037-1050. v d e WHO ICD-10 mental and behavioral disorders F · 290-319 Neurological/symptomatic Dementia Alzheimer's disease, multi-infarct dementia, Pick's disease, Creutzfeldt-Jakob disease, Huntington's disease, Parkinson's disease, AIDS dementia complex, Frontotemporal dementia, Elopement, Sundowning, Wandering · Delirium · Post-concussion syndrome · Organic brain syndrome Psychoactive substance alcohol drunkenness, alcohol dependence, alcoholic hallucinosis, Alcohol withdrawal, delirium tremens, Korsakoff's syndrome, alcohol abuse · opioids opioid dependency · sedative/hypnotic benzodiazepine withdrawal · cocaine cocaine dependence · general Intoxication, Drug abuse, Physical dependence, Withdrawal Psychotic disorder Schizophrenia disorganized schizophrenia · Schizophreniform disorder · Schizotypal personality disorder · Delusional disorder · Folie à deux · Schizoaffective disorder Mood affective Mania · Bipolar disorder · Clinical depression · Cyclothymia · Dysthymia Neurotic, stress-related and somatoform Anxiety disorder Agoraphobia, Panic disorder, Panic attack, Generalized anxiety disorder, Social anxiety, Social phobia · OCD · Acute stress reaction · PTSD · Adjustment disorder · Conversion disorder Ganser syndrome · Somatoform disorder Somatization disorder, Body dysmorphic disorder, Hypochondriasis, Nosophobia, Da Costa's syndrome, Psychalgia · Neurasthenia Physiological/physical behavioral Eating disorder: Anorexia nervosa · Bulimia nervosa Sleep disorder: Dyssomnia Hypersomnia, Insomnia · Parasomnia REM behavior disorder, Night terror · Nightmare Sexual dysfunction: Erectile dysfunction · Premature ejaculation · Vaginismus · Dyspareunia · Hypersexuality · Female sexual arousal disorder Postpartum depression · Postnatal psychosis Adult personality and behavior Personality disorder · Passive-aggressive behavior · Kleptomania · Trichotillomania · Voyeurism · Factitious disorder · Munchausen syndrome · Ego-dystonic sexual orientation · Fetishism Mental retardation Mental retardation Psychological development developmental disorder Specific: speech and language expressive language disorder, aphasia, expressive aphasia, receptive aphasia, Landau-Kleffner syndrome, lisp · Scholastic skills dyslexia, dysgraphia, Gerstmann syndrome · Motor function developmental dyspraxia Pervasive: Autism · Rett syndrome · Asperger syndrome Behavioral and emotional, childhood and adolescence onset ADHD · Conduct disorder · Oppositional defiant disorder · Separation anxiety disorder · Selective mutism · Reactive attachment disorder · Tic disorder · Tourette syndrome · Speech stuttering · cluttering Retrieved from http://en..org/wiki/Premature_ejaculation Categories: Andrology | Urology | Sexual and gender identity disorders | PenisHidden categories: Semi-protected | Articles that may contain original research since March 2008 | Medicine articles needing expert attention | articles needing rewrite | Cleanup from April 2008 | Articles with specifically-marked weasel-worded phrases | All articles with statements | Articles with statements since November 2007 | Articles with statements since January 2007 | Articles containing how-to sections Views Article Discussion View source History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages العربية Deutsch Español Français 한국어 Hrvatski Italiano עברית Nederlands 日本語 Polski Português Simple English Suomi Svenska Tiếng Việt Türkçe 中文 This page was last modified on 18 July 2008, at 14:16
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