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07-SEPTEMBER-2008 03:17:44 - biology For the drugs used in AIDS, please refer to protease inhibitor pharmacology. In biology and biochemistry, protease inhibitors are molecules that inhibit the function of peptidases old name: protease, hence the term protease inhibitor. Many naturally occurring protease inhibitors are proteins. In medicine, protease inhibitor is often used interchangeably with alpha 1-antitrypsin A1AT, which is abbreviated Pi for this reason.1 A1AT is indeed the protease inhibitor most often involved in disease, namely in alpha 1-antitrypsin deficiency. Contents 1 Classification 1.1 By protease 1.2 By mechanism 2 Compounds 3 External links 4 References Classification Protease inhibitors may be classified either by the type of protease the inhibit, or by their mechanism of action. By protease Classes of proteases are: Cysteine protease inhibitors Serine protease inhibitors serpins Trypsin inhibitors Threonine protease inhibitors Aspartic protease inhibitors Metalloprotease inhibitors By mechanism Classes of inhibitor mechanisms of action are: Suicide inhibitor Transition state inhibitor Protein protease inhibitor see serpins Chelating agents Compounds Aprotinin Bestatin Calpain inhibitor I and II Chymostatin E-64 Leupeptin N-acetyl-L-leucyl-L-leucyl-L-argininal alpha-2-Macroglobuline Pefabloc SC Pepstatin PMSF phenylmethanesulfonyl fluoride TLCK Trypsin inhibitors External links Sigma-Aldrich protease inhibitor overview References ^ OMIM - PROTEASE INHIBITOR 1; PI This enzyme-related article is a stub. v d e Pharmacology: enzyme inhibition Class Competitive inhibition - Uncompetitive inhibition - Non-competitive inhibition - Suicide inhibition - Mixed inhibition Substrate Oxidoreductase EC 1: Aromatase inhibitors - Lipoxygenase inhibitor - Monoamine oxidase inhibitors - COX-2 inhibitor Transferase EC 2: Integrase inhibitor - Protein kinase inhibitors - Reverse transcriptase inhibitors - COMT inhibitors Hydrolase EC 3: Acetylcholinesterase inhibitors - Phosphodiesterase inhibitors - Protease inhibitors ACE inhibitor, Trypsin inhibitor - Histone deacetylase inhibitor Lyase EC 4: Carbonic anhydrase inhibitors Retrieved from http://en..org/wiki/Protease_inhibitor_biology Categories: Protease inhibitors | Enzyme stubs Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Polski This page was last modified on 9 May 2008, at 22:42
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