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07-SEPTEMBER-2008 03:17:44 - Punicalagins Punicalagins are tannins, large polyphenol compound which are isomers of 2,3-S-hexahydroxydiphenoyl-4,6-S,S-gallagyl-D-glucose, hydrolysable tannins with a molecular weight of 1084. Punicalagins are the largest molecule found intact in rat plasma after oral ingestion1 and were found to show no toxic effects in rats who were given a 6% diet of punicalagins for 37 days2. Punicalagins are also found to be the major component responsible for pomegranate juice's antioxidant and health benefits3. Punicalagins are known to hydrolyze into smaller polyphenols such as ellagic acid in vivo where one potential mechanism is hydrolysis across the mitochondrial membrane of cultured human colon cells.4.5 A few dietary supplements and nutritional ingredients are available that contain extracts of whole pomegranate and/or are standardized to punicalagins, the marker compound of pomegranate. Extracts of pomegranate are also 'Generally Recognized As Safe' GRAS by the United States. It has been recommended to look for pomegranate ingredients that mimic the polyphenol ratio of the fruit, as potent synergistic effects have been observed in 'natural spectrum' extracts, especially pomegranate concentrate normalized to punicalagins6. A pomegranate extract standardized to punicalagins marketed under the name Pomella was found to absorb into the bloodstream after consumption in humans. A maximum 32% increase in plasma antioxidant status measured by ORAC was also noted in this study7. References ^ Cerda et al. Eur J Nutr. 2003 Jan;421:18-28. ^ Cerda et al. J. Agric. Food Chem. 2003, 51, 3493-3501 ^ Gil et al. J Agric Food Chem 2000 48 10 4581-89 ^ Seeram et al. Clin Chim Acta. 2004 Oct;3481-2:63-8. ^ Larrosa et al. J Nutr Biochem. 2006 Sep;179:611-25. ^ Seeram et al. J Nutr Biochemistry 2005 16 360-367. ^ Mertens-Talcott et al. J Agric Food Chem. 2006 Nov 15;5423:8956-8961 Retrieved from http://en..org/wiki/Punicalagins Categories: Nutrition | Phenols Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 1 June 2008, at 14:37
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