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07-SEPTEMBER-2008 03:17:44 - Surinabant Surinabant Systematic IUPAC name 5-4-bromophenyl-1-2,4-dichlorophenyl-4-ethyl- N-1-piperidinyl-1H-pyrazole-3-carboxamide Identifiers CAS number 288104-79-0 ATC code ? PubChem 9849616 Chemical data Formula C23H23BrCl2N4O Mol. mass 522.264 g/mol SMILES eMolecules PubChem Pharmacokinetic data Bioavailability ? Metabolism ? Half life ? Excretion ? Therapeutic considerations Pregnancy cat. ? Legal status Routes ? Surinabant SR-147,778 is a cannabinoid receptor type 1 antagonist developed by Sanofi-Aventis.1 It is being investigated as a potential treatment for nicotine addiction, to assist smoking cessation. It may also be developed as an anorectic drug to assist with weight loss, however there are already several CB1 antagonists or inverse agonists on the market or under development for this application,2 so surinabant is at present mainly being developed as an anti-smoking drug,3 with possible application in the treatment of other addictive disorders such as alcoholism.45 Other potential applications such as treatment of ADHD have also been proposed.6 References ^ Rinaldi-Carmona M, Barth F, Congy C, Martinez S, Oustric D, Pério A, Poncelet M, Maruani J, Arnone M, Finance O, Soubrié P, Le Fur G. SR147778 5-4-bromophenyl-1-2,4-dichlorophenyl-4-ethyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide, a new potent and selective antagonist of the CB1 cannabinoid receptor: biochemical and pharmacological characterization. Journal of Pharmacology and Experimental Therapeutics. 2004 Sep;3103:905-14. PMID 15131245 ^ Doggrell SA. Will the new CB1 cannabinoid receptor antagonist SR-147778 have advantages over rimonabant? Expert Opinion on Investigational Drugs. 2005 Mar;143:339-42. PMID 15833065 ^ Lamota L, Bermudez-Silva FJ, Marco EM, Llorente R, Gallego A, Rodríguez de Fonseca F, Viveros MP. Effects of adolescent nicotine and SR 147778 Surinabant administration on food intake, somatic growth and metabolic parameters in rats. Neuropharmacology. 2008 Jan;541:194-205. PMID 17720206 ^ Gessa GL, Serra S, Vacca G, Carai MA, Colombo G. Suppressing effect of the cannabinoid CB1 receptor antagonist, SR147778, on alcohol intake and motivational properties of alcohol in alcohol-preferring sP rats. Alcohol and Alcoholism. 2005 Jan-Feb;401:46-53. PMID 15582988 ^ Lallemand F, De Witte P. SR147778, a CB1 cannabinoid receptor antagonist, suppresses ethanol preference in chronically alcoholized Wistar rats. Alcohol. 2006 Jul;393:125-34. PMID 17127132 ^ Louis C, Terranova JP, Decobert M, Bizot JC, Francon D, Alonso R, Cohen C, Griebel G. Surinabant, a new CB1 receptor antagonist, displays efficacy in animal models of attention deficit/hyperactivity disorder. Behavioural Pharmacology 2005; 16:S42. Tablets This pharmacology-related article is a stub. v d e Drugs used in addictive disorders N07B Nicotine dependence/ Nicotinic agonist Nicotine - Bupropion - Dianicline - Varenicline - Lobeline - Mecamylamine - Clonidine - Scopolamine - Surinabant Alcohol dependence Disulfiram - Calcium carbimide - Acamprosate - Naltrexone - Nalmefene - Topiramate - Clonidine - Buprenorphine - Morphine Opioid dependence Buprenorphine - Methadone - Levacetylmethadol - Fentanyl - Dihydrocodeine - Dihydroetorphine - Clonidine - Lofexidine - Naltrexone - Ibogaine - 18-Methoxycoronaridine - Extended Release Morphine - Extended Release Hydromorphone Stimulant dependence Dexamphetamine - Bupropion - Vanoxerine - Nocaine - Vigabatrin Benzodiazepine dependence Clonidine - Diazepam - Phenytoin - Phenobarbital Cocaine dependence Bupropion - Vanoxerine - Nocaine - Baclofen - Vigabatrin Sedative-Hypnotic dependence Phenobarbital - Diazepam - Lorazepam - Clonidine - Chloral Hydrate v d e Cannabinoids Plant cannabinoids CBD CBDV CBN CBG CBV CBL THC THC-C4 THCV Cannabinoid metabolites 11-Hydroxy-THC 11-nor-9-Carboxy-THC Endogenous cannabinoids Arachidonoyl ethanolamide Anandamide or AEA 2-Arachidonoylglycerol 2-AG 2-Arachidonyl glyceryl ether noladin ether Virodhamine N-arachidonoyl-dopamine NADA; Oleamide Synthetic cannabinoid agonists Classical cannabinoids Dibenzopyrans A-41988 Ajulemic acid AM-087 AM-411 AM-855 AM-905 AM-906 AM-919 AM-938 AM-4030 AMG-1 AMG-3 AMG-36 AMG-41 Dexanabinol HU-211 DMHP Dronabinol HU-210 JWH-051 JWH-133 JWH-139 L-759,633 L-759,656 Levonantradol Nabilone Nabitan O-806 O-823 O-1057 O-1125 O-1238 O-2545 O-2694 Parahexyl THC-O-acetate THC-O-phosphate Nonclassical cannabinoids CP 47,497 CP 55,244 CP 55,940 HU-308 2-Isopropyl-5-methyl-1-2,6-dihydroxy-4-nonylphenylcyclohex-1-ene Aminoalkylindoles AM-630 AM-1241 JWH-015 JWH-018 JWH-073 JWH-081 JWH-200 L-768,242 Pravadoline WIN 55,212-2 Aminoalkylpyrroles JWH-030 JWH-147 JWH-307 Eicosanoids AM-883 Arachidonyl-2'-chloroethylamide Arachidonylcyclopropylamide Methanandamide O-585 O-689 O-1812 O-1860 O-1861 Others BAY 38-7271 BAY 59-3074 GW 842,166X JWH-171 O-2220 Endocannabinoid activity enhancers AM-404 CAY-10401 CAY-10402 N-arachidonoyl-serotonin O-1624 PF-622 PF-750 URB-597 URB-602 URB-754 Cannabinoid antagonists and inverse agonists AM-251 AM-281 AM-630 AVE-1625 BML-190 CAY-10508 CB-25 CB-52 JTE-907 LY-320,135 MK-9470 NESS-0327 O-1184 O-2050 O-2654 Rimonabant SLV-319 SR-144,528 Surinabant Taranabant VCHSR Retrieved from http://en..org/wiki/Surinabant Categories: Pharmacology stubs | Cannabinoids | CB1 receptor antagonists Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 9 May 2008, at 15:4
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