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07-SEPTEMBER-2008 03:17:44 - Taranabant Taranabant Systematic IUPAC name N-1S,2S-3-4-Chlorophenyl-2- 3-cyanophenyl-1-methylpropyl-2-methyl-2- 5-trifluoromethylpyridin-2-yloxypropanamide Identifiers CAS number 701977-09-5 ATC code A08AX PubChem ? Chemical data Formula C27H25ClF3N3O2 Mol. mass 515.95 Pharmacokinetic data Bioavailability ? Metabolism ? Half life ? Excretion ? Therapeutic considerations Pregnancy cat. ? Legal status Routes Oral Taranabant codenamed MK-0364 is a cannabinoid receptor type 1 inverse agonist being investigated as a potential treatment for obesity due to its anorectic effects.12 It was discovered by Merck Co. As of March 2008, it is currently undergoing Phase III clinical studies.3 References ^ Armstrong HE, Galka A, Lin LS, Lanza TJ Jr, Jewell JP, Shah SK, et al. Substituted acyclic sulfonamides as human cannabinoid-1 receptor inverse agonists. Bioorganic Medicinal Chemistry Letters. 2007 Apr 15;178:2184-7. PMID 17293109. doi:10.1016/j.bmcl.2007.01.087 ^ Fong TM, Guan XM, Marsh DJ, Shen CP, Stribling DS, Rosko KM, et al. Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-1S,2S-3-4-chlorophenyl-2-3-cyanophenyl-1-methylpropyl-2-methyl-2-5-trifluoromethylpyridin-2-yloxypropanamide MK-0364, in rodents. Journal of Pharmacology and Experimental Therapeutics. 2007 Jun;3213:1013-22. PMID 17327489. doi:10.1124/jpet.106.118737 ^ Merck Co., Inc. product pipeline. Retrieved on 2008-03-28. Tablets This pharmacology-related article is a stub. v d e Antiobesity preparations A08 -- see also anorectic Centrally acting Phentermine - Fenfluramine - Amfepramone - Dexfenfluramine - Mazindol - Cathine - Clobenzorex - Sibutramine - cannabinoids Rimonabant, Taranabant Peripherally acting Orlistat v d e Cannabinoids Plant cannabinoids CBD CBDV CBN CBG CBV CBL THC THC-C4 THCV Cannabinoid metabolites 11-Hydroxy-THC 11-nor-9-Carboxy-THC Endogenous cannabinoids Arachidonoyl ethanolamide Anandamide or AEA 2-Arachidonoylglycerol 2-AG 2-Arachidonyl glyceryl ether noladin ether Virodhamine N-arachidonoyl-dopamine NADA; Oleamide Synthetic cannabinoid agonists Classical cannabinoids Dibenzopyrans A-41988 Ajulemic acid AM-087 AM-411 AM-855 AM-905 AM-906 AM-919 AM-938 AM-4030 AMG-1 AMG-3 AMG-36 AMG-41 Dexanabinol HU-211 DMHP Dronabinol HU-210 JWH-051 JWH-133 JWH-139 L-759,633 L-759,656 Levonantradol Nabilone Nabitan O-806 O-823 O-1057 O-1125 O-1238 O-2545 O-2694 Parahexyl THC-O-acetate THC-O-phosphate Nonclassical cannabinoids CP 47,497 CP 55,244 CP 55,940 HU-308 2-Isopropyl-5-methyl-1-2,6-dihydroxy-4-nonylphenylcyclohex-1-ene Aminoalkylindoles AM-630 AM-1241 JWH-015 JWH-018 JWH-073 JWH-081 JWH-200 L-768,242 Pravadoline WIN 55,212-2 Aminoalkylpyrroles JWH-030 JWH-147 JWH-307 Eicosanoids AM-883 Arachidonyl-2'-chloroethylamide Arachidonylcyclopropylamide Methanandamide O-585 O-689 O-1812 O-1860 O-1861 Others BAY 38-7271 BAY 59-3074 GW 842,166X JWH-171 O-2220 Endocannabinoid activity enhancers AM-404 CAY-10401 CAY-10402 N-arachidonoyl-serotonin O-1624 PF-622 PF-750 URB-597 URB-602 URB-754 Cannabinoid antagonists and inverse agonists AM-251 AM-281 AM-630 AVE-1625 BML-190 CAY-10508 CB-25 CB-52 JTE-907 LY-320,135 MK-9470 NESS-0327 O-1184 O-2050 O-2654 Rimonabant SLV-319 SR-144,528 Surinabant Taranabant VCHSR Retrieved from http://en..org/wiki/Taranabant Categories: Pharmacology stubs | Anorectics | CB1 receptor antagonists | Pyridines | Nitriles Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 28 May 2008, at 20:03
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