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07-SEPTEMBER-2008 03:17:44 - Telmisartan Telmisartan Systematic IUPAC name 2-4-4-methyl-6-1-methylbenzoimidazol-2-yl- 2-propyl-benzoimidazol-1-ylmethylphenyl benzoic acid Identifiers CAS number 144701-48-4 ATC code C09CA07 PubChem 65999 DrugBank APRD01247 Chemical data Formula C33H30N4O2 Mol. mass 514.617 g/mol Pharmacokinetic data Bioavailability 42-100% Protein binding ≥99.5% Metabolism Minimal hepatic Half life 24 hours Excretion Faecal 97% Therapeutic considerations Pregnancy cat. D Au, D U.S. Legal status S4 Au, POM UK, ℞-only U.S. Routes Oral Telmisartan INN pronounced /tɛlmɪˈsɑrtən/ is an angiotensin II receptor antagonist ARB used in the management of hypertension. It is marketed under the trade names Micardis Boehringer Ingelheim, Pritor or Kinzal Bayer Schering Pharma, Telma Glenmark Pharma, Telday Torrent Pharmaceuticals and Teleact D by Ranbaxy. Pharmacology Generally, angiotensin II receptor blockers ARBs such as telmisartan bind to the angiotensin II type 1 AT1 receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle, ultimately leading to a reduction in arterial blood pressure. New studies suggest that telmisartan may also have PPARγ agonistic properties that could potentially confer beneficial metabolic effects. This observation is currently being explored in clinical trials. Clinical use Main article: Angiotensin II receptor antagonist External links http://www.pritor.com http://www.micardis.com/com/index.jsp http://www.pslgroup.com/dg/e6dce.htm http://www.ICMAedu.com v d e Agents acting on the renin-angiotensin system C09 ACE inhibitors Alacepril Benazepril Captopril Cilazapril Delapril Enalapril Fosinopril Imidapril Lisinopril Moexipril Perindopril Quinapril Ramipril Rentiapril Spirapril Temocapril Trandolapril Zofenopril Angiotensin II receptor antagonists AIIRA Azilsartan Candesartan Eprosartan Irbesartan Losartan Olmesartan Tasosartan Telmisartan Valsartan Renin inhibitors Aliskiren Remikiren Tablets This pharmacology-related article is a stub. Retrieved from http://en..org/wiki/Telmisartan Categories: Angiotensin II receptor antagonists | Pharmacology stubs Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Español Magyar Nederlands Polski Português This page was last modified on 12 June 2008, at 05
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