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07-SEPTEMBER-2008 03:17:44 - Treponema pallidum Treponema pallidum Scientific classification Kingdom: Eubacteria Phylum: Spirochaetes Class: Spirochaetes Order: Spirochaetales Family: Treponemataceae Genus: Treponema Species: T. pallidum Binomial name Treponema pallidum Schaudinn Hoffmann, 1905 Treponema pallidum is a gram-negative spirochaete bacterium. There are at least four known subspecies: T. pallidum pallidum, which causes syphilis; T. pallidum pertenue, which causes yaws; T. pallidum carateum, which causes pinta; and T. pallidum endemicum, which causes bejel. T. pallidum pallidum is a motile spirochaete that is generally acquired by close sexual contact, entering the host via breaches in squamous or columnar epithelium. The organism can also be transmitted to a fetus by transplacental passage during the later stages of pregnancy, giving rise to congenital syphilis. The helical structure of T. pallidum pallidum allows it to move in a corkscrew motion through viscous mediums such as mucus. It gains access to host's blood and lymph systems through tissue and mucus membranes. The subspecies causing yaws, pinta, and bejel are morphologically and serologically indistinguishable from T. pallidum pallidum syphilis; however, their transmission is not venereal in nature and the course of each disease is significantly different. In the July 17, 1998 issue of the journal Science, a group of biologists reported how they sequenced the genome of T. pallidum. The recent sequencing of the genomes of several spirochetes permits a thorough analysis of the similarities and differences within this bacterial phylum. Treponema pallidum subsp. pallidum has one of the smallest bacterial genomes at 1.14 million base pairs Mb and has limited metabolic capabilities, reflecting its adaptation through genome reduction to the rich environment of mammalian tissue. There is no vaccine for syphilis. The outer membrane of T. pallidum has too few surface proteins for an antibody to be effective. Efforts to develop a safe and effective syphilis vaccine have been hindered by uncertainty about the relative importance of humoral and cellular mechanisms to protective immunity and the fact that T. pallidum outer membrane proteins have not been unambiguously identified. See also Syphilis Rapid Plasma Reagin References and links Bak, Matthew. Treponema pallidum: The Etiologic Agent of Syphilis. 7 February 2006 Syphilis- CDC Fact Sheet. Centers for Disease Control and Prevention. May. 2004. Centers for Disease Control and Prevention. 7 February 2006 Retrieved from http://en..org/wiki/Treponema_pallidum Categories: Spirochaetes | Infectious disease stubs | Medicine stubs Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Bosanski Česky Deutsch Ελληνικά Español Euskara Français 한국어 Italiano Nederlands ‪Norsk bokmål‬ Português This page was last modified on 4 August 2008, at 10:50

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