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07-SEPTEMBER-2008 03:17:44 - Trypsin inhibitor Trypsin inhibitors are chemicals that reduce the availability of trypsin, an enzyme essential to nutrition of many animals, including humans. There are four commercial sources of trypsin inhibitors. Source Molecular weight Inhibitatory power Details Serum α1-antitrypsin 52 kDa Also known as serum trypsin inhibitor Lima beans 8-10 kDa 2.2 times weight There are six different lima bean inhibitors. Bovine pancreas 6.5 kDa 2.5 times weight Kunitz inhibitor is the best known pancreatic inhibitor. Chymotrypsin is also inhibited by this chemical, but less tightly. When extracted from lung tissue, this is known as aprotinin. Ovomucoid 8-10 kDa 1.2 times weight Ovomucoids are the glycoprotein protease inhibitors found in avian egg white. There are other protease inhibitors in ovomucoids as well. Soybeans 20.7-22.3 kDa 1.2 times weight Soybeans contain several inhibitors; the one in the chart is considered the primary one. All of them bind chymotryptin to a lesser degree. See also Serine protease inhibitor Protease inhibitor References Jones et al., Biochem., 2, 66, 1963 Lineweaver and Murray JBC, 171, 565 1947 Kunitz and Northrop J. Gen. Physiol., 19, 991 1936 Fraenkel-Conrat, et al., Arch. Biochem. Biophys., 37, 393 1952 Frattali, V., and Steiner, R.: Biochem., 7, 521 1968 External links MeSH Trypsin+inhibitors v d e Pharmacology: enzyme inhibition Class Competitive inhibition - Uncompetitive inhibition - Non-competitive inhibition - Suicide inhibition - Mixed inhibition Substrate Oxidoreductase EC 1: Aromatase inhibitors - Lipoxygenase inhibitor - Monoamine oxidase inhibitors - COX-2 inhibitor Transferase EC 2: Integrase inhibitor - Protein kinase inhibitors - Reverse transcriptase inhibitors - COMT inhibitors Hydrolase EC 3: Acetylcholinesterase inhibitors - Phosphodiesterase inhibitors - Protease inhibitors ACE inhibitor, Trypsin inhibitor - Histone deacetylase inhibitor Lyase EC 4: Carbonic anhydrase inhibitors Retrieved from http://en..org/wiki/Trypsin_inhibitor Categories: EC 3.4.21 | Enzyme kinetics Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 13 March 2008, at 08:24
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