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07-SEPTEMBER-2008 03:17:44 - remodeling Ventricular remodeling refers to the changes in size, shape, and function of the heart after injury to the left ventricle. The injury is typically due to acute myocardial infarction usually transmural or ST segment elevation infarction, but may be from a number of causes that result in increased pressure or volume overload forms of strain on the heart. Chronic hypertension, congenital heart disease with intracardiac shunting, and valvular heart disease may also lead to remodeling. After the insult occurs, a series of histopathological and structural changes occur in the left ventricular myocardium that lead to progressive decline in left ventricular performance. Ultimately, ventricular remodeling may result in diminished contractile systolic function and reduced stroke volume. Medically speaking, ventricular remodeling implies a decline in function even though the word remodeling usually implies improvement. The term reverse remodeling in cardiology implies an improvement in ventricular mechanics and function after a remote injury. Contents 1 Pathophysiology 2 Treatment 3 See also 4 References Pathophysiology The cardiac myocyte is the major cell involved in remodeling. Fibroblasts, collagen, the interstitium, and the coronary vessels to a lesser extent, also play a role. A common scenario for remodeling is after myocardial infarction. There is myocardial necrosis cell death and disproportionate thinning of the heart. This thin, weakened area is unable to withstand the pressure and volume load on the heart in the same manner as the other healthy tissue. As a result there is dilatation of the chamber arising from the infarct region. The initial remodeling phase after a myocardial infarction results in repair of the necrotic area and scar formation that may, to some extent, be considered beneficial since there is an improvement in or maintenance of LV function and cardiac output. Over time, however, as the heart undergoes ongoing remodeling, it becomes less elliptical and more spherical. Ventricular mass and volume increase, which together adversely affect cardiac function. Eventually, diastolic function, or the heart's ability to relax between contractions may become impaired, further causing decline. Treatment Many factors influence the time course and extent of remodeling, including the severity of the insult, secondary events recurrent ischemia or infarction, neurohormonal activation, genetic factors and gene expression, and treatment. Medications may attenuate remodeling. Angiotensin-converting enzyme ACE inhibitors have been consistently shown to decrease remodeling in animal models or transmural infarction and chronic pressure overload. Clinical trials have shown that ACE inhibitor therapy after myocardial infarction leads to improved myocardial performance, improved ejection fraction, and decreased mortality compared to patients treated with placebo. Likewise, inhibition of aldosterone, either directly or indirectly, leads to improvement in remodeling.1 Early correction of congenital heart defects, if appropriate, may prevent remodeling, as will treatment of chronic hypertension or valvular heart disease. Often, reverse remodeling, or improvement in left ventricular function, will also be seen. See also Ventricular Restoration: The Dor Procedure References ^ NEJM - Eplerenone, a Selective Aldosterone Blocker, in Patients with Left Ventricular Dysfunction after Myocardial Infarction 1 Pitt B, Remme W, Zannad F, et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 2003; 348:1309-21. http://content.nejm.org/cgi/content/full/348/14/1309 Cardiac remodeling--concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling. J Am Coll Cardiol. 2000 Mar 1;353:569-82. Sutton, MG, Sharpe, N. Left ventricular remodeling after myocardial infarction: pathophysiology and therapy. Circulation 2000; 101:2981 Konstam, MA, Kronenberg, MW, Rousseau, MF, et al. Effects of the angiotensin converting enzyme inhibitor enalapril on the long-term progression of left ventricular dilatation in patients with asymptomatic systolic dysfunction. SOLVD Studies of Left Ventricular Dysfunction Investigators. Circulation 1993; 88:2277. Greenberg, B, Quinones, MA, Koilpillai, C, et al. Effects of long-term enalapril therapy on cardiac structure and function in patients with left ventricular dysfunction. Results of the SOLVD echocardiography substudy. Circulation 1995; 91:2573. Doughty, RN, Whalley, GA, Gamble, G, et al. Left ventricular remodeling with carvedilol in patients with congestive heart failure due to ischemic heart disease. J Am Coll Cardiol 1997; 29:1060. Kheradvar, A, Gorman, RC, Gorman, JH 3rd, Zeeshan, A, Gharib, M. Evaluation of isovolumic relaxation phase in the process of ventricular remodeling following myocardial infarction. Conf Proc IEEE Eng Med Biol Soc. 2004;5:3654-7. Cohn JN. Cardiac Remodeling, UpToDate v.13.1 www.uptodateonline.com. Accessed July 17, 2005. Retrieved from http://en..org/wiki/Ventricular_remodeling Categories: Cardiomyopathy | Cardiology Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 29 May 2008, at 20:56
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So many of us do not eat a balanced diet, get enough sleep, have too much stress, or are impacted with toxins and pollutants. Drinking 2 ounces of MonaVie twice a day will help your body detoxify as well as build your immune system. Its the smartest thing you can do for yourself, so start today. Buying MonaVie through our company guarantees you support 7 days a week and, if you would like to share MonaVie with your family and friends we will guide you from start to finish.
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