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16-September-2008 20:42:48 - Taurine Taurine IUPAC name Taurine Molecular formula C2H7NO3S Identifiers CAS number 107-35-7 PubChem 1123 SMILES NCCS=OO=O Properties Molar mass 125.14 g/mol Density 1.734 g/cm³ at -173.15 °C Melting point 305.11 °C Except where noted otherwise, data are given for materials in their standard state at 25 °C, 100 kPa Infobox references Taurine, or 2-aminoethanesulfonic acid, is an organic acid. It is also a major constituent of bile and can be found in the lower intestine and amounts in the tissues of many animals and in humans as well.12 Taurine is a derivative of the sulfur-containing sulfhydryl amino acid, cysteine. Taurine is the only known naturally occurring sulfonic acid.3 Taurine is named after the Latin taurus, which means bull or ox, as it was first isolated from ox bile in 1827 by German scientists Friedrich Tiedemann and Leopold Gmelin.4 It is often called an amino acid, even in scientific literature,567 but as it lacks a carboxyl group it is not strictly an amino acid.8 It does contain a sulfonate group and may be called an amino sulfonic acid. Small polypeptides have been identified which contain taurine but to date no aminoacyl tRNA synthetase has been identified as specifically recognizing taurine and capable of incorporating it onto a tRNA.9 Contents 1 Biosynthesis 2 Physiological roles 3 Taurine and cats 4 Taurine and bird development 5 Synthesis and production 6 As a functional food 7 References 8 External links Biosynthesis The major pathway for mammalian taurine synthesis occurs in the liver via the cysteine sulfinic acid pathway. In this pathway, the sulfhydryl group of cysteine is first oxidized to cysteine sulfinic acid by the enzyme cysteine dioxygenase. Cysteine sulfinic acid, in turn, is decarboxylated by Sulfinoalanine decarboxylase EC 4.1.1.29 to form hypotaurine. It is unclear whether hypotaurine is then spontaneously or enzymatically oxidized to yield taurine. Taurine in the pharmaceutical and lab setting is synthesized through a combination of cysteine, methionine and vitamin E. It is naturally produced in testicles of many mammals. Urban legends surrounding the source of taurine have included bull urine extract and bull semen. While it's true that taurine is found in both sources, it is not the source of taurine in the pharmaceutical or food industry. And while taurine is sometimes extracted from the intestines of cattle, many food industry sources, including the popular energy drink Red Bull 1, make efforts to use synthesized sources that are vegetarian friendly. Physiological roles Taurine is conjugated via its amino terminal group with chenodeoxycholic acid and cholic acid to form the bile salts sodium taurochenodeoxycholate and sodium taurocholate. The low pKa 1.5 of taurine's sulfonic acid group ensures that this moiety is negatively charged in the pH ranges normally found in the intestinal tract and thus improves the surfactant properties of the cholic acid conjugate, which can be found in many energy drinks today. Taurine has also been implicated in a wide array of other physiological phenomena including inhibitory neurotransmission,10 long-term potentiation in the striatum/hippocampus, membrane stabilization, feedback inhibition of neutrophil/macrophage respiratory bursts, adipose tissue regulation, calcium homeostasis and recovery from osmotic shock. It also acts as an antioxidant. .11 Prematurely born infants who lack the enzymes needed to convert cystathionine to cysteine may become deficient in taurine. Thus, taurine is a dietary essential nutrient in these individuals and is often added to many infant formulas as a measure of prudence. There is also evidence that taurine is beneficial for adult human blood pressure and possibly, the alleviation of other cardiovascular ailments.12 Recent studies have also shown that taurine can influence and possibly reverse defects in nerve blood flow, motor nerve conduction velocity, and nerve sensory thresholds in experimental diabetic neuropathic rats.1314 Taurine levels were found to be significantly lower in vegans than in a control group on a standard American diet. Plasma taurine was 78% of control values, and urinary taurine 29%.15 According to animal studies, taurine produces anxiolytic effect and may act as a modulator or anti-anxiety agent in the central nervous system.1617 In recent years, taurine has become a common ingredient in energy drinks. Taurine is often used in combination with performance enhancing substances, such as creatine and anabolic steroids, partly due to recent findings in mice that taurine alleviates muscle fatigue in strenuous workouts and raises exercise capacity.18 Taurine is also used in some contact lens solutions.19 Taurine has also been shown in diabetic rats to decrease weight and decrease blood sugar.20 According to one study, it has no effect on insulin secretion or insulin sensitivity in humans.21 However, there is evidence that taurine may exert a beneficial effect in preventing diabetes-associated microangiopathy and tubulointerstitial injury in diabetic nephropathy.2223 In humans suffering essential hypertension, taurine supplementation resulted in measurable decreases in blood pressure.24 Taurine and cats Taurine is essential for cat health, as cats cannot synthesize the compound. The absence of taurine causes a cat's retina to slowly degenerate, causing eye problems and eventually irreversible blindness - a condition known as central retinal degeneration CRD2526, as well as hair loss and tooth decay. In addition, taurine deficiency can cause feline dilated cardiomyopathy, and supplementation can reverse left ventricular systolic dysfunction. Taurine is now a requirement of the Association of American Feed Control Officials AAFCO and any dry or wet food product labeled approved by the AAFCO should have a minimum of 0.1% taurine.27 Taurine and bird development Recent research has provided evidence that taurine is essential in early bird development of passerines. Many passerines, regardless of spider availability, seek out many taurine-rich spiders to feed their young particularly in their youngest stages of life. Researchers later compared the behaviors and development of birds fed a taurine-supplemented diet to a control diet and found that juveniles that were fed taurine-rich diets as neonates were much larger risk takers and more adept at spatial learning tasks.28 Synthesis and production In 1993, approximately 5,000-6,000 t of taurine was produced; 50% for pet food manufacture, 50% in pharmaceutical applications.3 Synthetic taurine is obtained from isethionic acid 2-hydroxyethanesulfonic acid, which in turn is obtained from the reaction of ethylene oxide with aqueous sodium bisulfite.29 Another approach is the reaction of aziridine with sulfurous acid. This leads directly to taurine.citation needed As a functional food Taurine is used as a functional food in many energy drinks and energy products and more recently, in a chocolate bar30. Energy Drink Incomprehensive List Taurine concentration Normalized concentration Full Throttle 1194 mg/16 fl oz 2 servings 252 mg/100 ml JetSet 1000 mg/10.5 fl oz 1 serving 322 mg/100 ml Jolt Cola 2800 mg/23.5 fl oz 403 mg/100 ml Monster 1000 mg/8 fl oz 1 serving 423 mg/100 ml NOS 1000 mg/8 fl oz 1 serving 423 mg/100 ml Red Bull 1000 mg/8.3 fl oz 1 serving 408 mg/100 ml Relentless 2000 mg/16 fl oz 2 servings 423 mg/100 ml Rip It 1000 mg/8 fl oz 2 serving 423 mg/100 ml Rockstar 2000 mg/16 fl oz 2 servings 423 mg/100 ml SoBe Adrenaline Rush 960 mg/16 fl oz 2 servings 203 mg/100 ml Starbucks Doubleshot 1800 mg/15 fl oz 2 servings 406 mg/100 ml V 420 mg/8 fl oz 178 mg/100 ml Vitamin Water Power C Dragon Fruit Flavor 25 mg/20 fl oz 2.5 servings 4.2 mg/100 ml Vitamin Energy 2000 mg/16 fl oz 423 mg/1oo ml Von Dutch 2000 mg/16 fl oz 2 servings 423 mg/100 ml Despite being present in many energy drinks, it has not been proven to be energy-giving. A study of mice herarily unable to transport taurine suggests that it is needed for proper maintenance and functioning of skeletal muscles.31 References ^ Bouckenooghe T, Remacle C, Reusens B 2006. Is taurine a functional nutrient?. Curr Opin Clin Nutr 9 6: 728-733. ^ Brosnan J, Brosnan M 2006. The sulfur-containing amino acids: an overview.. J Nutr 136 6 Suppl: 1636S-1640S. PMID 16702333. ^ a b Tully, Paul S. Sulfonic Acids. In Kirk-Othmer Encyclopedia of Chemical Technology. John Wiley Sons, Inc. Published online 2000. doi:10.1002/0471238961.1921120620211212.a01 ^ F. Tiedemann, L. Gmelin 1827. Einige neue Bestandtheile der Galle des Ochsen. Annalen der Physik 85 2: 326-337. doi:10.1002/andp.18270850214. ^ Stapleton, PP; L O'Flaherty, HP Redmond, and DJ Bouchier-Hayes 1998. Host defense--a role for the amino acid taurine?. Journal of Parenteral and Enteral Nutrition 22 1: 42-48. doi:10.1177/014860719802200142. PMID 9437654. Retrieved on 2006-08-19. ^ Weiss, Stephen J.; Roger Klein, Adam Slivka, and Maria Wei 1982. Chlorination of Taurine by Human Neutrophils. Journal of Clinical Investigation 70 3: 598-607. doi:10.1172/JCI110652. PMID 6286728. Retrieved on 2006-08-19. ^ Kirk, Kiaran; and Julie Kirk 1993. Volume-regulatory taurine release from a human heart cancer cell line. FEBS Letters 336 1: 153-158. doi:10.1016/0014-57939381630-I. ^ Carey, Francis A. 1987 2006. Organic Chemistry, 6th ed., New York: McGraw Hill, 1149. ISBN 0-07-282837-4. Amino acids are carboxylic acids that contain an amine function. ^ Lahdesmaki, P 1987. Biosynthesis of taurine peptides in brain cytoplasmic fraction in vitro.. Int J Neuroscience 37 1-2: 79-84. doi:10.3109/00207458708991804. ^ Olive MF. Interactions between taurine and ethanol in the central nervous system. Amino Acids 2002;234:345-57 ^ Antioxidant role and subcellular location of hypotaurine and taurine in human neutrophils. Green TR, Fellman JH, Eicher AL, Pratt KL. Biochimica et biophysica acta. 1991 Jan 23;10731:91-7. ^ Militante, J. D.; J. B. Lombardini November 2002. Treatment of hypertension with oral taurine: exp0/en.2005-1007. PMID 16627576. Retrieved on 2006-08-22. ^ Li F, Abatan OI, Kim H, Burnett D, Larkin D, Obrosova IG, Stevens MJ 2006 Jun. Taurine reverses neurological and neurovascular deficits in Zucker diabetic fatty rats.. Neurobiology of Disease 22 3: 669-676. doi:10.1016/j.nbd.2006.01.012. PMID 16624563. ^ Pop-Busui R, Sullivan KA, Van Huysen C, Bayer L, Cao X, Towns R, Stevens MJ 2001 Apr. Depletion of taurine in experimental diabetic neuropathy: implications for nerve metabolic, vascular, and functional deficits.. Exp Neurol. 168 2: 259-272. doi:10.1006/exnr.2000.7591. PMID 11259114. ^ Laidlaw S, Shultz T, Cecchino J, Kopple J 1988 Plasma and urine taurine levels in vegans. American Journal of Clinical Nutrition, vol. 47, pp. 660-663. ^ Kong WX, Chen SW, Li YL, et al 2006. Effects of taurine on rat behaviors in three anxiety models. Pharmacol. Biochem. Behav. 83 2: 271-6. doi:10.1016/j.pbb.2006.02.007. PMID 16540157. ^ Taurine induces anti-anxiety by activating strychnine-sensitive glycine receptor in vivo. Zhang CG, Kim SJ. Annals of Nutrition Metabolism 2007;514:379-86. Epub 2007 Aug 29. ^ U. Warskulat, U. Flogel, C. Jacoby, H.-G. Hartwig, M. Thewissen, M. W. Merx, A. Molojavyi, B. Heller-Stilb, J. Schrader and D. Haussinger 2004. Taurine transporter knockout depletes muscle taurine levels and results in severe skeletal muscle impairment but leaves cardiac function uncompromised. Faseb J.: 03-0496fje. doi:10.1096/fj.03-0496fje. PMID 14734644. ^ James, TJ; Hansen D; Nolfi, J 2004-04-01. Ocular Health and Next Generation Solutions. Optometric Management. Retrieved on 2008-01-10. ^ Yutaka Nakaya, Asako Minami, Nagakatsu Harada, Sadaichi Sakamoto, Yasuharu Niwa and Masaharu Ohnaka January 2000. Taurine improves insulin sensitivity in the Otsuka Long-Evans Tokushima Fatty rat, a model of spontaneous type 2 diabetes. American Journal of Clinical Nutrition 71 1: 54-58. PMID 10617946. ^ Effect of taurine treatment on insulin secretion and action, and on serum lipid levels in overweight men with a genetic predisposition for type II diabetes mellitus. C. Brøns, C. Spohr, H. Storgaard, J. Dyerberg, A. Vaag. European Journal of Clinical Nutrition 2004 58, 1239-1247. ^ Taurine prevents high-glucose-induced human vascular endothelial cell apoptosis. Wu QD, Wang JH, Fennessy F, Redmond HP, Bouchier-Hayes D. The American journal of physiology. 1999 Dec;2776 Pt 1:C1229-38. ^ Taurine prevents apoptosis induced by high ambient glucose in human tubule renal cells. Verzola D, Bertolotto MB, Villaggio B, Ottonello L, Dallegri F, Frumento G, Berruti V, Gandolfo MT, Garibotto G, Deferran G. Journal of investigative medicine: the official publication of the American Federation for Clinical Research. 2002 Nov;506:443-51. ^ Treatment of hypertension with oral taurine: experimental and clinical studies. Militante JD, Lombardini JB. Amino acids. 2002;234:381-93. ^ Taurine And Its Importance In Cat Foods. Iams Cat Nutrition Library 2004. Retrieved on 2006-08-22. ^ Nutrient Requirements of Cats. Nutrient Requirements of Cats, Revised ion, 1986 1986. Retrieved on 2006-09-10. ^ AAFCO ^ Arnold, K.E.; Ramsay, S.L.; Donaldson, C.; Adam, A. 2007. Parental prey selection affects risk-taking behaviour and spatial learning in avian offspring. Proceedings of the Royal Society B: Biological Sciences 274 1625: 2563-2569. doi:10.1098/rspb.2007.0687. Retrieved on 2008-03-26. ^ Kurt Kosswig. Sulfonic Acids, Aliphatic. in Ullmann's Encyclopedia of Industrial Chemistry. Wiley-VCH, 2000. doi:10.1002/14356007.a25_503 ^ Boniface, Dan 2008-01-23. New candy bar offers more than just a sugar high, 9news.com. Retrieved on 2008-01-24. ^ U. Warskulat, U. Flogel, C. Jacoby, H.-G. Hartwig, M. Thewissen, M. W. Merx, A. Molojavyi, B. Heller-Stilb, J. Schrader and D. Haussinger 2004. Taurine transporter knockout depletes muscle taurine levels and results in severe skeletal muscle impairment but leaves cardiac function uncompromised. Faseb J.: 03-0496fje. doi:10.1096/fj.03-0496fje. PMID 14734644. External links BBC report on possible uses of taurine and alcohol damage - 2005 Taurine Rules - energy drink review blog v d e Dietary supplements Types Amino acids Bodybuilding supplement Energy drink Energy bar Fatty acids Herbal Supplements Minerals Prebiotics Probiotics Lactobacillus, Bifidobacterium Vitamins Whole food supplements Vitamins and minerals Retinol Vitamin A B vitamins: Thiamine B1 Riboflavin B2 Niacin B3 Pantothenic acid B5 Pyridoxine B6 Biotin B7 Folic acid B9 Cyanocobalamin B12 Ascorbic acid Vitamin C Ergocalciferol and Cholecalciferol Vitamin D Tocopherol Vitamin E Naphthoquinone Vitamin K Calcium Choline Chlorine Chromium Cobalt Copper Fluorine Iodine Iron Magnesium Manganese Molybdenum Phosphorus Potassium Selenium Sodium Sulfur Zinc Other common ingredients Carnitine Chondroitin sulfate Cod liver oil Copper gluconate Creatine/Creatine supplements Dietary fiber Elemental calcium Ephedra Fish oil Folic acid Ginseng Glucosamine Glutamine Iron supplements Japanese Honeysuckle Krill oil Lingzhi Linseed oil Melatonin Red yeast rice Royal jelly Saw palmetto Spirulina Taurine Wheatgrass Wolfberry Yohimbine Zinc gluconate Related articles Codex Alimentarius Enzyte Metabolife Hadacol Nutraceutical Multivitamin Nutrition Retrieved from http://en..org/wiki/Taurine Categories: Amines | Sulfonic acidsHidden categories: All articles with statements | Articles with statements since January 2008 Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages ÄŒesky Dansk Deutsch Eesti Español Esperanto Français í•œêµì–´ Bahasa Indonesia Italiano עברית Magyar Nederlands 日本語 ‪Norsk bokmÃ¥l‬ Polski Português Română РуÑ?Ñ?кий SlovenÅ¡Ä?ina Suomi Svenska Türkçe Walon ä¸æ–‡ This page was last modified on 16 August 2008, at 06:15
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