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20-September-2008 10:08:30 - Caffeine For other uses, see Caffeine disambiguation. Caffeine Caffeine Caffeine IUPAC name 1,3,7-trimethyl-1H-purine-2,63H,7H-dione Other names 1,3,7-trimethylxanthine, trimethylxanthine, theine, methyltheobromine Identifiers CAS number 58-08-2 RTECS number EV6475000 SMILES Cn1cnc2NCC=ONCC=Oc12 Properties Molecular formula C8H10N4O2 Molar mass 194.19 g·mol-1 Appearance Odorless, white needles or powder Density 1.2 g·cm-3, solid Melting point 237 °C non-equilibrium, superheated Boiling point 178 °C sublimes Solubility in water 22 mg·mL-1 25 °C 180 mg·mL-1 80 °C 670 mg·mL-1 100 °C Hazards MSDS External MSDS Main hazards May be fatal if inhaled, swallowed or absorbed through the skin. NFPA 704 1 2 0 Flash point N/A LD50 192 mg/kg rat, oral1 Except where noted otherwise, data are given for materials in their standard state at 25 °C, 100 kPa Infobox references Caffeine is a bitter white crystalline xanthine alkaloid that acts as a psychoactive stimulant drug and a mild diuretic speeds up urine production2 in humans and other animals. Caffeine was discovered by a German chemist, Friedrich Ferdinand Runge, in 1819. He coined the term kaffein, a chemical compound in coffee, which in English became caffeine.3 Caffeine is also called guaranine when found in guarana, mateine when found in mate, and theine when found in tea; all of these names are synonyms for the same chemical compound. Caffeine is found in varying quantities in the beans, leaves, and fruit of over 60 plants, where it acts as a natural pesticide that paralyzes and kills certain insects feeding on the plants. It is most commonly consumed by humans in infusions extracted from the beans of the coffee plant and the leaves of the tea bush, as well as from various foods and drinks containing products derived from the kola nut or from cacao. Other sources include yerba mate, guarana berries, and the Yaupon Holly. In humans, caffeine is a central nervous system CNS stimulant, having the effect of temporarily warding off drowsiness and restoring alertness. Beverages containing caffeine, such as coffee, tea, soft drinks and energy drinks enjoy great popularity. Caffeine is the world's most widely consumed psychoactive substance, but unlike most others, it is legal and unregulated in nearly all jurisdictions. In North America, 90% of adults consume caffeine daily.4 The U.S. Food and Drug Administration lists caffeine as a Multiple Purpose Generally Recognized as Safe Food Substance.5 One 2008 study suggested that women consuming 200 milligrams or more of caffeine per day had about twice the miscarriage risk as women who had none, while another 2008 study found no link between miscarriage and caffeine consumption.6 Contents 1 Occurrence 2 History 3 Pharmacology 3.1 Metabolism 3.2 Mechanism of action 3.3 Effects when taken in moderation 3.4 Tolerance and withdrawal 3.5 Overuse 3.5.1 Caffeine intoxication 3.5.2 Anxiety and sleep disorders 3.6 Parkinson's disease 3.7 Effects on memory and learning 3.8 Effects on the heart 3.9 Effects on children 3.10 Caffeine intake during pregnancy 4 Production 5 Decaffeination 5.1 Water extraction 5.2 Supercritical carbon dioxide extraction 5.3 Extraction by nonhazardous organic solvents 6 Stereochemistry 7 Religion 8 References 9 External links 9.1 General information 9.2 News 9.3 Health 10 Appendix 10.1 Relative content: comparison of different sources Occurrence Roasted coffee beans, the world's primary source of caffeine Roasted coffee beans, the world's primary source of caffeine Caffeine is a plant alkaloid, found in many plant species, where it acts as a natural pesticide, with high caffeine levels being reported in seedlings that are still developing foliages, but are lacking mechanical protection;7 caffeine paralyzes and kills certain insects feeding upon the plant.8 High caffeine levels have also been found in the surrounding soil of coffee bean seedlings. It is therefore understood that caffeine has a natural function as both a natural pesticide and as an inhibitor of seed germination of other nearby coffee seedlings9 thus giving it a better chance of survival. The most commonly used caffeine-containing plants are coffee, tea, and to a lesser extent10 cocoa. Other, less commonly used, sources of caffeine include the yerba mate11 and guarana plants, which are sometimes used in the preparation of teas and energy drinks. Two of caffeine's alternative names, mateine12 and guaranine,13 are derived from the names of these plants. Some yerba mate enthusiasts assert that mateine is a stereoisomer of caffeine, which would make it a different substance altogether.11 This is not true because caffeine is an achiral molecule, and therefore has no enantiomers; nor does it have other stereoisomers. The disparity in experience and effects between the various natural caffeine sources could be due to the fact that plant sources of caffeine also contain widely varying mixtures of other xanthine alkaloids, including the cardiac stimulants theophylline and theobromine and other substances such as polyphenols which can form insoluble complexes with caffeine.14 The world's primary source of caffeine is the coffee bean the seed of the coffee plant, from which coffee is brewed. Caffeine content in coffee varies widely depending on the type of coffee bean and the method of preparation used;15 even beans within a given bush can show variations in concentration. In general, one serving of coffee ranges from 40 milligrams, for a single shot 30 milliliters of arabica-variety espresso, to about 100 milligrams for a cup 120 milliliters of drip coffee. Generally, dark-roast coffee has less caffeine than lighter roasts because the roasting process reduces the bean's caffeine content.1617 Arabica coffee normally contains less caffeine than the robusta variety.15 Coffee also contains trace amounts of theophylline, but no theobromine. Tea is another common source of caffeine. Tea usually contains about half as much caffeine per serving as coffee, depending on the strength of the brew, growing conditions, processing techniques and other variables. Certain types of tea, may contain somewhat more caffeine than other teas. Tea contains small amounts of theobromine and slightly higher levels of theophylline than coffee. Preparation and many other factors have a significant impact on tea, and color is a very poor indicator of caffeine content.18 Teas like the pale Japanese green tea gyokuro, for example, contain far more caffeine than much darker teas like lapsang souchong, which has very little. Caffeine is also a common ingredient of soft drinks such as cola, originally prepared from kola nuts. Soft drinks typically contain about 10 to 50 milligrams of caffeine per serving. By contrast, energy drinks such as Red Bull contain as much as 80 milligrams of caffeine per serving. The caffeine in these drinks either originates from the ingredients used or is an additive derived from the product of decaffeination or from chemical synthesis. Guarana, a prime ingredient of energy drinks, contains large amounts of caffeine with small amounts of theobromine and theophylline in a naturally occurring slow-release excipient.19 Chocolate derived from cocoa contains a small amount of caffeine. The weak stimulant effect of chocolate may be due to a combination of theobromine and theophylline as well as caffeine.20 Chocolate contains too little of these compounds for a reasonable serving to create effects in humans that are on par with coffee. A typical 28-gram serving of a milk chocolate bar has about as much caffeine as a cup of decaffeinated coffee. In recent years various manufacturers have begun putting caffeine into shower products such as shampoo and soap, claiming that caffeine can be absorbed through the skin.21 However, the effectiveness of such products has not been proven, and they are likely to have little stimulatory effect on the central nervous system because caffeine is not readily absorbed through the skin.22 In recent years various manufacturers have begun putting caffeine into tablets, claiming that using caffeine of pharmaceutical quality improves mental alertness and is used by students that are studying for their exams. It is also used by people who work or drive for long hours. 23 History A coffeehouse in Palestine, circa 1900 A coffeehouse in Palestine, circa 1900 Main articles: History of cocoa, History of coffee, Origin and early history of tea Humans have consumed caffeine since the Stone Age.24 Early peoples found that chewing the seeds, bark, or leaves of certain plants had the effects of easing fatigue, stimulating awareness, and elevating mood. Only much later was it found that the effect of caffeine was increased by steeping such plants in hot water. Many cultures have legends that attribute the discovery of such plants to people living many thousands of years ago. According to one popular Chinese legend, the Emperor of China Shennong, reputed to have reigned in about 3000 BC, accidentally discovered that when some leaves fell into boiling water, a fragrant and restorative drink resulted.25 Shennong is also mentioned in Lu Yu's Cha Jing, a famous early work on the subject of tea.26 The history of coffee has been recorded as far back as the ninth century. During that time, coffee beans were available only in their native habitat, Ethiopia. A popular legend traces its discovery to a goatherder named Kaldi, who apparently observed goats that became elated and sleepless at night after browsing on coffee shrubs and, upon trying the berries that the goats had been eating, experienced the same vitality. The earliest literary mention of coffee may be a reference to Bunchum in the works of the 9th century Persian physician al-Razi. In 1587, Malaye Jaziri compiled a work tracing the history and legal controversies of coffee, entitled Undat al safwa fi hill al-qahwa. In this work, Jaziri recorded that one Sheikh, Jamal-al-Din al-Dhabhani, mufti of Aden, was the first to adopt the use of coffee in 1454, and that in the 15th century the Sufis of Yemen routinely used coffee to stay awake during prayers. Towards the close of the 16th century, the use of coffee was recorded by a European resident in Egypt, and about this time it came into general use in the Near East. The appreciation of coffee as a beverage in Europe, where it was first known as Arabian wine, dates from the 17th century. During this time coffee houses were established, the first being opened in Constantinople and Venice. In Britain, the first coffee houses were opened in London in 1652, at St Michael's Alley, Cornhill. They soon became popular throughout Western Europe, and played a significant role in social relations in the 17th and 18th centuries.27 The kola nut, like the coffee berry and tea leaf, appears to have ancient origins. It is chewed in many West African cultures, individually or in a social setting, to restore vitality and ease hunger pangs. In 1911, kola became the focus of one of the earliest documented health scares when the US government seized 40 barrels and 20 kegs of Coca-Cola syrup in Chattanooga, Tennessee, alleging that the caffeine in its drink was injurious to health.28 On March 13, 1911, the government initiated The United States v. Forty Barrels and Twenty Kegs of Coca-Cola, hoping to force Coca-Cola to remove caffeine from its formula by making claims, such as that the excessive use of Coca-Cola at one girls' school led to wild nocturnal freaks, violations of college rules and female proprieties, and even immoralities.29 Although the judge ruled in favor of Coca-Cola, two bills were introduced to the U.S. House of Representatives in 1912 to amend the Pure Food and Drug Act, adding caffeine to the list of habit-forming and deleterious substances which must be listed on a product's label. The earliest evidence of cocoa use comes from residue found in an ancient Mayan pot dated to 600 BC. In the New World, chocolate was consumed in a bitter and spicy drink called xocoatl, often seasoned with vanilla, chile pepper, and achiote. Xocoatl was believed to fight fatigue, a belief that is probably attributable to the theobromine and caffeine content. Chocolate was an important luxury good throughout pre-Columbian Mesoamerica, and cocoa beans were often used as currency. Chocolate was introduced to Europe by the Spaniards and became a popular beverage by 1700. They also introduced the cacao tree into the West Indies and the Philippines. It was used in alchemical processes, where it was known as Black Bean. In 1819, the German chemist Friedrich Ferdinand Runge isolated relatively pure caffeine for the first time. According to Runge, he did this at the behest of Johann Wolfgang von Goethe.30 In 1827, Oudry isolated theine from tea, but it was later proved by Mulder and Jobat that theine was the same as caffeine.30 The structure of caffeine was elucidated near the end of the 19th century by Hermann Emil Fischer, who was also the first to achieve its total synthesis.31 This was part of the work for which Fischer was awarded the Nobel Prize in 1902. Today, global consumption of caffeine has been estimated at 120,000 tonnes per annum,32 making it the world's most popular psychoactive substance. This number equates to one serving of a caffeine beverage for every person, per day. In North America, 90% of adults consume some amount of caffeine daily.4 Pharmacology Caffeine is a central nervous system and metabolic stimulant,33 and is used both recreationally and medically to reduce physical fatigue and restore mental alertness when unusual weakness or drowsiness occurs. Caffeine stimulates the central nervous system first at the higher levels, resulting in increased alertness and wakefulness, faster and clearer flow of thought, increased focus, and better general body coordination, and later at the spinal cord level at higher doses.34 Once inside the body, it has a complex chemistry, and acts through several mechanisms as described below. Metabolism Caffeine is metabolized in the liver into three primary metabolites: paraxanthine 84%, theobromine 12%, and theophylline 4% Caffeine is metabolized in the liver into three primary metabolites: paraxanthine 84%, theobromine 12%, and theophylline 4% Caffeine is completely absorbed by the stomach and small intestine within 45 minutes of ingestion. After ingestion it is distributed throughout all tissues of the body and is eliminated by first-order kinetics.35 The half-life of caffeine-the time required for the body to eliminate one-half of the total amount of caffeine consumed at a given time-varies widely among individuals according to such factors as age, liver function, pregnancy, some concurrent medications, and the level of enzymes in the liver needed for caffeine metabolism. In healthy adults, caffeine's half-life is approximately 3-4 hours. In women taking oral contraceptives this is increased to 5-10 hours,36 and in pregnant women the half-life is roughly 9-11 hours.37 Caffeine can accumulate in individuals with severe liver disease, increasing its half-life up to 96 hours.38 In infants and young children, the half-life may be longer than in adults; half-life in a newborn baby may be as long as 30 hours. Other factors such as smoking can shorten caffeine's half-life.39 Caffeine is metabolized in the liver by the cytochrome P450 oxidase enzyme system specifically, the 1A2 isozyme into three metabolic dimethylxanthines,40 which each have their own effects on the body: Paraxanthine 84%: Has the effect of increasing lipolysis, leading to elevated glycerol and free fatty acid levels in the blood plasma. Theobromine 12%: Dilates blood vessels and increases urine volume. Theobromine is also the principal alkaloid in cocoa, and therefore chocolate. Theophylline 4%: Relaxes smooth muscles of the bronchi, and is used to treat asthma. The therapeutic dose of theophylline, however, is many times greater than the levels attained from caffeine metabolism. Each of these metabolites is further metabolized and then excreted in the urine. Mechanism of action Caffeine's principal mode of action is as an antagonist of adenosine receptors in the brain. They are presented here side by side for comparison. Caffeine's principal mode of action is as an antagonist of adenosine receptors in the brain. They are presented here side by side for comparison. Caffeine acts through multiple mechanisms involving both action on receptors and channels on the cell membrane, as well as intracellular action on calcium and cAMP pathways. By virtue of its purine structure it can act on some of the same targets as adenosine-related nucleosides and nucleotides, like the cell surface P1 GPCRs for adenosine, as well as the intracellular Ryanodine receptor RyR which is the physiological target of cADPR cyclic ADP-ribose, and cAMP-phosphodiesterase cAMP-PDE. Although the action is agonistic in some cases, it is antagonistic in others. Physiologically, however, caffeine action is unlikely due to increased RyR opening, as it requires plasma concentration above lethal dosage. The action is most likely through adenosine receptors.citation needed Like alcohol, nicotine, and antidepressants, caffeine readily crosses the blood-brain barrier. Once in the brain, the principal mode of action is as an antagonist of adenosine receptors found in the brain.41 The caffeine molecule is structurally similar to adenosine, and binds to adenosine receptors on the surface of cells without activating them an antagonist mechanism of action. Therefore, caffeine acts as a competitive inhibitor. Given that caffeine is a competitive inhibitor of adenosine, an understanding of adenosine's role in the central nervous system is crucial. One of the roles of adenosine is as a signal that one neuron can use to tell another to stop releasing neurotransmitter because it cannot handle the stimulation. In doing this it is acting as a retrograde neurotransmitter a neurotransmitter that is released by the postsynaptic cell and received by the presynaptic cell in the direction opposite to most neurotransmitters.42 Adenosine is the final breakdown product of adenosine triphosphate ATP, the cellular currency of energy. When cells have used the energy of adenosine triphosphate it breaks into adenosine diphosphate, which is then used for energy and broken down into adenosine monophosphate. Finally, the last phosphate bond is broken for energy in the cell's last attempt to squeeze molecular power from this molecule: adenosine monophosphate is broken down into simple adenosine. At this point, the neuron has very little energy left for the successful firing of an action potential. Adenosine from this process is then released from the postsynaptic cell and binds to receptors on the presynaptic cell. If the release of adenosine is great enough, this release has an inhibitory effect on the release of neurotransmitter from the presynaptic neuron's axon terminal. This triggers a mechanism that inhibits the further secretion of excitatory neurotransmitters into the synapse. It is as if the postsynaptic neuron is telling the presynaptic neuron that its resources are scarce and it needs time to recover before further stimulation by neurotransmitters. Thus, adenosine works to inhibit activity of the central nervous system. As a competitive inhibitor of adenosine, caffeine binds to the adenosine receptor, but does not trigger the chemical cascade that inhibits neurotransmitter release. It blocks the site so adenosine cannot bind and get its message across the synapse. By inhibiting adenosine, caffeine excites the central nervous system and allows for continued stimulation of neurons that otherwise would not fire or would not release neurotransmitter into the synapse.42434445 The reduction in adenosine activity results in increased activity of the neurotransmitter dopamine, largely accounting for its stimulatory effects. This inhibition of adenosine is the only known biochemical effect that caffeine has in humans at the concentrations achieved during normal human consumption of the drug.42 Further, coffee tea drinkers on the whole do not consume enough caffeine to release dopamine in the nucleus accumbens shell, the key structure associated with motivation, reward addiction. However, in high doses, caffeine induces dopamine release in nucleus accumbens, not unlike other psychostimulants, such as cocaine.46 In low and moderate doses, caffeine appears to increase dopamine and acetylcholine release in the prefrontal cortex PFC providing a mechanism for reinforcment and stimulates the caudate nucleus, increasing wakefulness locomotor activity. Sustained caffeine usage causes tolerance to the prefrontal cortical dopamine-mediated effects and hence the locomotor stimulation, but not to its cholinergic effects in the PFC, which could account for its capability for sustained arousal even in the caffeine-tolerant.474849 Caffeine also increases levels of epinephrine/adrenaline,50 possibly via a different mechanism, as well as glucose, insulin, and C-peptide levels. 51 Acute usage of caffeine also increases levels of serotonin, causing positive changes in mood.52 Caffeine is also a known competitive inhibitor of the enzyme cAMP-phosphodiesterase cAMP-PDE, which converts cyclic AMP cAMP in cells to its noncyclic form, allowing cAMP to build up in cells. Cyclic AMP participates in activation of Protein Kinase A PKA to begin the phosphorylation of specific enzymes used in glucose synthesis. By blocking its removal caffeine intensifies and prolongs the effects of epinephrine and epinephrine-like drugs such as amphetamine, methamphetamine, or methylphenidate. Increased concentrations of cAMP in parietal cells causes an increased activation of protein kinase A PKA which in turn increases activation of H+/K+ ATPase, resulting finally in increased gastric acid secretion by the cell. Caffeine and theophylline can freely diffuse into cells and causes intracellular calcium release independent of extracellular calcium from the calcium stores in the endoplasmic reticulumER. This release is only partially blocked by Ryanodine receptor blockade with ryanodine, dantrolene, ruthenium red, and procaine thus may involve ryanodine receptor and probably some additional calcium channels, but completely abolished after calcium depletion of ER by SERCA inhibitors like Thapsigargin TG or cyclopiazonic acid CPA.53 The action of caffeine on the ryanodine receptor may depend on both cytosolic and the luminal ER concentrations of Ca2+. At low millimolar concentration of caffeine, the RyR channel open probability Po is significantly increased mostly due to a shortening of the lifetime of the closed state. At concentrations 5 mM, caffeine opens RyRs even at picomolar cytosolic Ca2+ and dramatically increases the open time of the channel so that the calcium release is stronger than even an action potential can generate. This mode of action of caffeine is probably due to mimicking the action of the physiologic metabolite of NAD called cADPR cyclic ADP ribose which has a similar potentiating action on Ryanodine receptors. Caffeine may also directly inhibit delayed rectifier and A-type K+ currents and activate plasmalemmal Ca2+ influx in certain vertebrate and invertebrate neurons. The metabolites of caffeine contribute to caffeine's effects. Theobromine is a vasodilator that increases the amount of oxygen and nutrient flow to the brain and muscles. Theophylline, the second of the three primary metabolites, acts as a smooth muscle relaxant that chiefly affects bronchioles and acts as a chronotrope and inotrope that increases heart rate and efficiency. The third metabolic derivative, paraxanthine, is responsible for an increase in the lipolysis process, which releases glycerol and fatty acids into the blood to be used as a source of fuel by the muscles.54 Caffeine has a significant effect on spiders, which is reflected in their web construction Caffeine has a significant effect on spiders, which is reflected in their web construction Effects when taken in moderation The precise amount of caffeine necessary to produce effects varies from person to person depending on body size and degree of tolerance to caffeine. It takes less than an hour for caffeine to begin affecting the body and a mild dose wears off in three to four hours.34 Consumption of caffeine does not eliminate the need for sleep: it only temporarily reduces the sensation of being tired. With these effects, caffeine is an ergogenic: increasing the capacity for mental or physical labor. A study conducted in 1979 showed a 7% increase in distance cycled over a period of two hours in subjects who consumed caffeine compared to control tests.55 Other studies attained much more dramatic results; one particular study of trained runners showed a 44% increase in race-pace endurance, as well as a 51% increase in cycling endurance, after a dosage of 9 milligrams of caffeine per kilogram of body weight.56 The extensive boost shown in the runners is not an isolated case; additional studies have reported similar effects. Another study found 5.5 milligrams of caffeine per kilogram of body mass resulted in subjects cycling 29% longer during high intensity circuits.57 Caffeine citrate has proven to be of short and long term benefit in treating the breathing disorders of apnea of prematurity and bronchopulmonary displasia in premature infants.58 The only short term risk associated with caffeine citrate treatment is a temporary reduction in weight gain during the therapy,59 and longer term studies 18 to 21 months have shown lasting benefits of treatment of premature infants with caffeine.6061 While relatively safe for humans, caffeine is considerably more toxic to some other animals such as dogs, horses and parrots due to a much poorer ability to metabolize this compound. Caffeine has a much more significant effect on spiders, for example, than most other drugs do.62 Caffeine relaxes the internal anal sphincter muscles and thus should be avoided by those with fecal incontinence.63 Tolerance and withdrawal Caffeine content of select common food and drugs.6465 Product Serving size Caffeine per serving mg Caffeine per litre mg Caffeine tablet regular strength 1 tablet 100 - Caffeine tablet extra strength 1 tablet 200 - Excedrin tablet 1 tablet 65 - Chocolate, Dark Hershey's Special Dark 1 bar 43 g; 1.5 oz 31 - Chocolate, Milk Hershey Bar 1 bar 43 g; 1.5 oz 10 - Coffee, brewed 207 mL 7 U.S. fl oz 80-135 386-652 Coffee, drip 207 mL 7 U.S. fl oz 115-175 555-845 Coffee, decaffeinated 207 mL 7 U.S. fl oz 5 24 Coffee, espresso 44-60 mL 1.5-2 U.S. fl oz 100 1691-2254 Coffee, Starbucks Tall 12 U.S. fl oz 240 650-700 Tea, leaf or bag 177 mL 6 U.S. fl oz 50 281 Tea, green 177 mL 6 U.S. fl oz 30 169 Soft drink, Coca-Cola Classic 355 mL 12 U.S. fl oz 34 96 Soft drink, Mountain Dew 355 mL 12 U.S. fl oz 54.5 154 Soft drink, Jolt Cola 695 mL 23.5 U.S. fl oz 280 402 Red Bull 250 mL 8.2 U.S. fl oz 80 320 Monster Energy 473 mL 16 U.S. fl oz 160 338 Wired X344 473 mL 16 U.S. fl oz 344 727 Foosh Energy Mints 1 mint 100 - Buzz Bites 1 chew 100 - Buckfast Tonic Wine 750 mL 25.4 U.S. fl oz 281 375 Because caffeine is primarily an antagonist of the central nervous system's receptors for the neurotransmitter adenosine, the bodies of individuals who regularly consume caffeine adapt to the continual presence of the drug by substantially increasing the number of adenosine receptors in the central nervous system. This increase in the number of the adenosine receptors makes the body much more sensitive to adenosine, with two primary consequences.66 First, the stimulatory effects of caffeine are substantially reduced, a phenomenon known as a tolerance adaptation. Second, because these adaptive responses to caffeine make individuals much more sensitive to adenosine, a reduction in caffeine intake will effectively increase the normal physiological effects of adenosine, resulting in unwelcome withdrawal symptoms in tolerant users.66 Other research questions the idea that up-regulation of adenosine receptors is responsible for tolerance to the locomotor stimulant effects of caffeine, noting, among other things, that this tolerance is insurmountable by higher doses of caffeine it should be surmountable if tolerance was due to an increase in receptors, and that the increase in adenosine receptor number is modest and does not explain the large tolerance which develops to caffeine.67 Caffeine tolerance develops very quickly, especially among heavy coffee and energy drink consumers. Complete tolerance to sleep disruption effects of caffeine develops after consuming 400 mg of caffeine 3 times a day for 7 days. Complete tolerance to subjective effects of caffeine was observed to develop after consuming 300 mg 3 times per day for 18 days, and possibly even earlier.68 In another experiment, complete tolerance of caffeine was observed when the subject consumed 750-1200 mg per day while incomplete tolerance to caffeine has been observed in those that consume more average doses of caffeine.69 Because adenosine, in part, serves to regulate blood pressure by causing vasodilation, the increased effects of adenosine due to caffeine withdrawal cause the blood vessels of the head to dilate, leading to an excess of blood in the head and causing a headache and nausea. Reduced catecholamine activity may cause feelings of fatigue and drowsiness. A reduction in serotonin levels when caffeine use is stopped can cause anxiety, irritability, inability to concentrate and diminished motivation to initiate or to complete daily tasks; in extreme cases it may cause mild depression. Together, these effects have come to be known as a crash.70 Withdrawal symptoms-possibly including headache, irritability, an inability to concentrate, and stomach aches71-may appear within 12 to 24 hours after discontinuation of caffeine intake, peak at roughly 48 hours, and usually last from one to five days, representing the time required for the number of adenosine receptors in the brain to revert to normal levels, uninfluenced by caffeine consumption. Analgesics, such as aspirin, can relieve the pain symptoms, as can a small dose of caffeine.72 Most effective is a combination of both an analgesic and a small amount of caffeine. This is not the only case where caffeine increases the effectiveness of a drug. Caffeine makes pain relievers 40% more effective in relieving headaches and helps the body absorb headache medications more quickly, bringing faster relief.73 For this reason, many over-the-counter headache drugs include caffeine in their formula. It is also used with ergotamine in the treatment of migraine and cluster headaches as well as to overcome the drowsiness caused by antihistamines. Overuse In large amounts, and especially over extended periods of time, caffeine can lead to a condition known as caffeinism.7475 Caffeinism usually combines caffeine dependency with a wide range of unpleasant physical and mental conditions including nervousness, irritability, anxiety, tremulousness, muscle twitching hyperreflexia, insomnia, headaches, respiratory alkalosis76 and heart palpitations.77 Furthermore, because caffeine increases the production of stomach acid, high usage over time can lead to peptic ulcers, erosive esophagitis, and gastroesophageal reflux disease.78 There are four caffeine-induced psychiatric disorders recognized by the Diagnostic and Statistical Manual of Mental Disorders, Fourth ion: caffeine intoxication, caffeine-induced anxiety disorder, caffeine-induced sleep disorder, and caffeine-related disorder not otherwise specified NOS. Caffeine intoxication An acute overdose of caffeine, usually in excess of about 300 milligrams, dependent on body weight and level of caffeine tolerance, can result in a state of central nervous system over-stimulation called caffeine intoxication,79 colloquially caffeine jitters. The symptoms of caffeine intoxication are not unlike overdoses of other stimulants. It may include restlessness, nervousness, excitement, insomnia, flushing of the face, increased urination, gastrointestinal disturbance, muscle twitching, a rambling flow of thought and speech, irritability, irregular or rapid heart beat, and psychomotor agitation.77 In cases of much larger overdoses mania, depression, lapses in judgment, disorientation, loss of social inhibition, delusions, hallucinations, psychosis, rhabdomyolysis, and death may occur.8081 In cases of extreme overdose, death can result. The median lethal dose LD50 given orally, is 192 milligrams per kilogram in rats.1 The LD50 of caffeine in humans is dependent on weight and individual sensitivity and estimated to be about 150 to 200 milligrams per kilogram of body mass, roughly 80 to 100 cups of coffee for an average adult taken within a limited time frame that is dependent on half-life. Though achieving lethal dose with caffeine would be exceptionally difficult with regular coffee, there have been reported deaths from overdosing on caffeine pills, with serious symptoms of overdose requiring hospitalization occurring from as little as 2 grams of caffeine.82838485 Death typically occurs due to ventricular fibrillation brought about by effects of caffeine on the cardiovascular system. Treatment of severe caffeine intoxication is generally supportive, providing treatment of the immediate symptoms, but if the patient has very high serum levels of caffeine then peritoneal dialysis, hemodialysis, or hemofiltration may be required. Anxiety and sleep disorders Two infrequently diagnosed caffeine-induced disorders that are recognized by the American Psychiatric Association APA are caffeine-induced sleep disorder and caffeine-induced anxiety disorder, which can result from long-term excessive caffeine intake. In the case of caffeine-induced sleep disorder, an individual regularly ingests high doses of caffeine sufficient to induce a significant disturbance in his or her sleep, sufficiently severe to warrant clinical attention.79 A study in the British Journal of Addiction concluded that caffeinism, although infrequently diagnosed, may afflict as many as one person in ten of the population.75 Parkinson's disease Several large studies have shown that caffeine intake is associated with a reduced risk of developing Parkinson's disease PD in men, but studies in women have been inconclusive.86 The mechanism by which caffeine affects PD remains a mystery. In animal models, researchers have shown that caffeine can prevent the loss of dopamine-producing nerve cells seen in Parkinson's Disease, but researchers still do not know how this occurs.87 Effects on memory and learning An array of studies found that caffeine could have nootropic effects, inducing certain changes in memory and learning. However, it is still not definitively clear whether the effect is negative or positive. Researchers have found that long-term consumption of low dose caffeine slowed hippocampus-dependent learning and impaired long-term memory. Caffeine consumption for 4 weeks also significantly reduced hippocampal neurogenesis compared to controls during the experiment. The conclusion was that long-term consumption of caffeine could inhibit hippocampus-dependent learning and memory partially through inhibition of hippocampal neurogenesis. 88 In one study, caffeine was added to rat neurons in vitro. The dendritic spines a part of the brain cell used in forming connections between neurons taken from the hippocampus a part of the brain associated with memory grew by 33% and new spines formed. After an hour or two, however, these cells returned to their original shape.89 Another study showed that subjects-after receiving 100 milligrams of caffeine-had increased activity in brain regions located in the frontal lobe, where a part of the working memory network is located, and the anterior cingulum, a part of the brain that controls attention. The caffeinated subjects also performed better on the memory tasks.90 However, a different study showed that caffeine could impair short term memory and increase the likelihood of the tip of the tongue phenomenon. The study allowed the researchers to suggest that caffeine could aid short-term memory when the information to be recalled is related to the current train of thought, but also to hypothesize that caffeine hinders short-term memory when the train of thought is unrelated.91 In essence, focused thought coupled with caffeine consumption increases mental performance. Effects on the heart Caffeine increases the levels of cAMP in the heart cells, mimicking the effects of epinephrine. cAMP diffuses through the cell and acts as a secondary messenger, activating protein kinase A PKA; cAMP-dependent protein kinase. According to one study, caffeine, in the form of coffee, significantly reduces the risk of heart disease in epidemiological studies. However, the protective effect was found only in participants who were not severely hypertensive i.e. patients that are not suffering from a very high blood pressure. Furthermore, no significant protective effect was found in participants aged less than 65 years or in cerebrovascular disease mortality for those aged equal or more than 65 years.92 Effects on children Scientific studies contradict the common belief that caffeine consumption causes stunted growth in children.93 However, as with adults, nausea, urinary urgency, nervousness, or other effects from an elevated caffeine intake via chocolate milk, sodas, cold medicines, iced tea, coffee and other products that are widely used, may be reasons to limit the amount of caffeine that is consumed each day.94 Caffeine intake during pregnancy The Food Standards Agency has recommended that pregnant women should limit their caffeine intake to less than 300 mg of caffeine a day - the equivalent of four cups of coffee a day. A higher intake may be associated with miscarriage.9596 Dr De-Kun Li of Kaiser Permanente Division of Research, which appears in the American Journal of Obstetrics and Gynecology, concludes that an intake of 200 milligrams or more per day, representing two or more cups, significantly increases the risk of miscarriage.97 However, Dr. David Savitz, a professor in community and preventive medicine at New York's Mount Sinai School of Medicine and lead author of the other new study on the subject published in the January issue of Epidemiology, found no link between miscarriage and caffeine consumption.6 Production Anhydrous dry USP-grade caffeine Anhydrous dry USP-grade caffeine Caffeine extracted from coffee and tea during the decaffeination process is sold or used as an additive. Being readily available as a byproduct of decaffeination, caffeine is not usually synthesized.98 If desired, it may be synthesized from dimethyl urea and malonic acid.99 Decaffeination Main article: Decaffeination Pure caffeine is a white powder, and can be extracted from a variety of natural sources. Caffeine extraction is an important industrial process and can be performed using a number of different solvents. Benzene, chloroform, trichloroethylene and dichloromethane have all been used over the years but for reasons of safety, environmental impact, cost and flavor, they have been superseded by the following main methods: Water extraction Coffee beans are soaked in water. The water, which contains not only caffeine but also many other compounds which contribute to the flavor of coffee, is then passed through activated charcoal, which removes the caffeine. The water can then be put back with the beans and evaporated dry, leaving decaffeinated coffee with a good flavor.100 Coffee manufacturers recover the caffeine and resell it for use in soft drinks and over-the-counter caffeine tablets. Supercritical carbon dioxide extraction Supercritical carbon dioxide is an excellent nonpolar solvent for caffeine as well as many other organic compounds, and is safer than the organic solvents that are used for caffeine extraction. The extraction process is simple: CO2 is forced through the green coffee beans at temperatures above 31.1 °C and pressures above 73 atm. Under these conditions, CO2 is in a supercritical state: it has gaslike properties which allow it to penetrate deep into the beans but also liquid-like properties which dissolve 97-99% of the caffeine. The caffeine-laden CO2 is then sprayed with high pressure water to remove the caffeine. The caffeine can then be isolated by charcoal adsorption as above or by distillation, recrystallization, or reverse osmosis.100 Extraction by nonhazardous organic solvents Organic solvents such as ethyl acetate present much less health and environmental hazard than previously used chlorinated and aromatic solvents. The hydrolysis products of ethyl acetate are ethanol and acetic acid, both nonhazardous in small quantities. Another method is to use triglyceride oils obtained from spent coffee grounds. Stereochemistry The nitrogen atoms are all essentially planar in sp2 orbital hybridisation. Even though some are often drawn with three single bonds, the lone pairs on these atoms are involved in resonance with adjacent double-bonded carbon atoms, resulting in the caffeine molecule having aromatic character. Religion Some Latter-day SaintsMormons and Christian Scientists101 do not consume caffeine. Followers of both religions believe that God wishes them to be free of all addictions. The Church of Jesus Christ of Latter-day Saints has said the following in regards to caffeinated beverages, With reference to cola drinks, the Church has never officially taken a position on this matter, but the leaders of the Church have advised, and we do now specifically advise, against the use of any drink containing harmful habit-forming drugs under circumstances that would result in acquiring the habit. Any beverage that contains ingredients harmful to the body should be avoided. Priesthood Bulletin, Feb. 1972, p. 4. See also Word of Wisdom. Gaudiya Vaishnava Hindus generally also abstain from caffeine, as it clouds the mind and over-stimulates the senses. To be initiated under a guru, one must have had no caffeine along with alcohol, nicotine and other drugs for at least a year. References ^ a b Peters, Josef M. 1967. Factors Affecting Caffeine Toxicity: A Review of the Literature. 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Role of adenosine receptors in caffeine tolerance. J. Pharmacol. Exp. Ther. 256 1: 62-8. PMID 1846425. ^ Caffeine - A Drug of Abuse? ^ Information About Caffeine Dependence ^ Health risks of Stimulants, healthandgoodness.com ^ Juliano, L M 2004-09-21. A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features.. Psychopharmacology 176 1: 1-29. doi:10.1007/s00213-004-2000-x. ^ Sawynok, J January 1995. Pharmacological rationale for the clinical use of caffeine.. Drugs 49 1: 37-50. doi:10.1152/physrev.00004.2004. PMID 7705215. ^ Headache Triggers: Caffeine. WebMD June 2004. Retrieved on 2006-08-14. ^ Mackay, DC; Rollins JW. 1989 Summer. Caffeine and caffeinism. Journal of the Royal Naval Medical Service 75 2: 65-7. PMID 2607498. ^ a b James, JE; KP Stirling September 1983. Caffeine: A summary of some of the known and suspected deleterious effects of habitual use. 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Korea: Epub 184: 976-80, ISSN 0343-6993, http://www.ncbi.nlm.nih.gov/pubmed/17400186?ordinalpos=1itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum . ^ Caffeine clue to better memory, BBC News 1999-10-12. ^ Caffeine Boosts Short-Time Memory. ^ Lesk VE, Womble SP. 2004. Caffeine, priming, and tip of the tongue: evidence for plasticity in the phonological system.. Behavioral Neuroscience. 118 2: 453-61. doi:10.1037/0735-7044.118.3.453. PMID 15174922. ^ Greenberg, J.A.; Dunbar, C.C.; Schnoll, R.; Kokolis, R.; Kokolis, S.; Kassotis, J. Feb 2007. Caffeinated beverage intake and the risk of heart disease mortality in the elderly: a prospective analysis. Am J Clin Nutr 85 2: 392-398. PMID 17284734. ^ Fact or fiction: Common diet myths dispelled. MSNBC December 2006. Retrieved on 2007-05-10. ^ Caffeine and Your Child. KidsHealth January 2005. Retrieved on 2007-05-10. ^ Agency issues caffeine advice to pregnant women ^ Study: Caffeine may boost miscarriage risk ^ Kaiser Permanente Study Shows Newer, Stronger Evidence that Caffeine During Pregnancy Increases Miscarriage Risk ^ Simon Tilling. Crystalline Caffeine. Bristol University. ^ Ted Wilson, Norman J. Temple 2004. Beverages in Nutrition and Health. Humana Press, 172. ISBN 1588291731. ^ a b Senese, Fred 2005-09-20. How is coffee decaffeinated?. General Chemistry Online. Retrieved on 2006-08-21. ^ Voices of Faith: April 12, 2008. Retrieved on 2008-05-13. External links Pharmacy and Pharmacology portal Look up Caffeine in Wiktionary, the free dictionary. General information How Stuff Works: How Caffeine Works Erowid Caffeine Vaults National Geographic January 2005: Caffeine Caffeine Zone: Social and Medical info on caffeine and its effects. #caffeine! The Caffeine Information Archive Naked Scientists Online: Why do plants make caffeine? The Physician and Sportsmedicine: Caffeine: A User's Guide The Consumers Union Report on Licit and Illicit Drugs, Caffeine-Part 1 Part 2 Coffee: A Little Really Does Go a Long Way, NPR, September 28, 2006 Does coffee really give you a buzz? by John Triggs in the Daily Express April 17 2007 Caffeine: ChemSub Online News Alcohol and Drugs History Society: Caffeine news page National Post: Caffeine linked to psychiatric disorders Caffeine Withdrawal Recognized as a Disorder Health Is Caffeine a Health Hazard? eMedicine Caffeine-Related Psychiatric Disorders The Effects Of Caffeine Addiction Caffeine: Psychological Effects, Use Abuse Protects brain from Alzheimer's? Drinking Coffee is a Healthy Lifestyle Choice Appendix Relative content: comparison of different sources Caffeine equivalents12 In general, each of the following contains approximately 200 milligrams of caffeine: One 200 milligram caffeine pill One 12 fluid ounce cup of regular Starbucks coffee 355 millilitres One and one quarter 16 fluid ounce cans of Monster Energy 590 millilitres One and a half pounds of milk chocolatea 680 grams Two 8 fluid ounce containers of regular coffee 470 millilitres 1/2 tube of Spazzstick Caffeinated Lip Balm Two Foosh Energy Mints Two Buzz Bites Chocolate Energy Chews Two and a half 10 fluid ounce bottles of Bawls caffeinated drink 740 millilitres Three 6 fluid ounce cups of black tea 0.54 litres 70 mg per 6 oz cup1 Three standard Excedrin pills Three 8 fluid ounce cups of Red Bull energy drink 710 millilitres Four 8 fluid ounce cups of Vault energy drink 1.0 litre Five 1 fluid ounce shots of espresso from robusta beans 150 millilitres Five 8 fluid ounce cups of Mountain Dew 1.2 litres Five 12 fluid ounce cans of typical soda pop 1.8 litres variable Eight and a half 8 fluid ounce cups of Coca-Cola Classic 68 fl oz is approximately 2.0 litres Ten 8 fluid ounce cups of green tea 2.4 litres Fifty 8 fluid ounce cups of decaffeinated coffee 12 litres Notes: a. Chocolate and other products of cacao contain substantial quantities of other caffeine-like chemicals especially theobromine as well as actual caffeine. The properties of these substances are in at least some respects very similar to caffeine. v d e Coffee Production by country Angola · Brazil · Colombia · Costa Rica · Ecuador · El Salvador · Ethiopia · Guatemala · Guatemala · Haiti · India · Indonesia · Kenya · Mexico · Nicaragua · Uganda · Vietnam Coffee topics History of coffee · Economics of coffee · Coffee and health · Coffee and the environment Species and varieties List of varieties · Coffea arabica: Kenya AA, Kona, Jamaican Blue Mountain · Coffea canephora Coffea robusta: Kopi Luwak · Coffea liberica: Kape Barako Major chemicals in coffee Caffeine · Cafestol Coffee processing Coffee roasting · Home roasting coffee · Corretto · Decaffeination Coffee preparation Coffee percolator · Espresso lungo, ristretto · Drip brew from coffeemakers · French press · Turkish coffee · Instant coffee · Chemex · Moka pot Popular coffee beverages Americano/Long black · Café au lait/Café con leche · Caffè corretto/Liqueur coffee · Cafe mocha · Cà phê sữa đá · Cappuccino · Coffee milk · Cortado · Greek frappé coffee · Indian filter coffee · Irish coffee · Latte/Flat white · Macchiato espresso, latte · Iced coffee · Frappuccino · Red eye · Affogato Coffee and lifestyle Social aspects of coffee · Coffee ceremony · Coffeehouse · Caffè · Café · Kopi tiam · Viennese café · Caffè sospeso · Coffee cupping · Coffee break/Fika v d e Stimulants Alkylamines Cyclopentamine Geranamine Isometheptene Octodrine Propylhexedrine Tuamine Alphapyrrolidinylalkiophenones α-PPP MDPPP MDPV MPBP MPHP MPPP MOPPP Pyrovalerone Cholinergics ABT-089 ABT-418 Anabasine Arecoline Cotinine Cytisine Dianicline Epibatidine Epiboxidine GTS-21 Ispronicline Nicotine Rivanicline Tebanicline Varenicline Convulsants Bicuculline DMCM Gabazine Pentetrazol Picrotoxin Strychnine Thujone Eugeroics Adrafinil Armodafinil Carphedon Modafinil Phenethylamines 4-Bromomethcathinone 4-Fluoroamphetamine 4-Fluoromethamphetamine 4-Fluoromethcathinone 4-Methylmethcathinone 4-MTA Aletamine Amfepentorex Amphechloral Amphetamine Dextroamphetamine, Adderall Amphetaminil Benzphetamine Bupropion Cathinone Chlorphentermine Clenbuterol Clobenzorex Clortermine Diethylpropion Dimethoxyamphetamine Dimethylamphetamine Dimethylcathinone Ephedrine Epinephrine Ethcathinone Ethylamphetamine Fenethylline Fenfluramine Fenproporex Fludorex Furfenorex Levomethamphetamine Lisdexamfetamine MDMA Mefenorex Methamphetamine Methcathinone Methoxyphedrine Methylone Octopamine Ortetamine Parahydroxyamphetamine PCA PIA PMA PMEA PMMA PPAP Phendimetrazine Phenmetrazine Phentermine Phenylephrine Phenylpropanolamine Propylamphetamine Pseudoephedrine Selegiline Synephrine Tiflorex Xylopropamine Phenylaminooxazoles 4-Methyl-aminorex Aminorex Clominorex Fenozolone Fluminorex Pemoline Thozalinone Piperazines 2C-B-BZP BZP GBR-12783 GBR-12935 GBR-13069 GBR-13098 GBR-13119 MeOPP MBZP Vanoxerine Piperidines 2-Benzylpiperidine Desoxypipradrol Diphemethoxidine Ethylphenidate HDMP-28 --Methyl-1-methyl-4β-2-naphthylpiperidine-3β-carboxylate Methylphenidate Dexmethylphenidate Nocaine Phacetoperane Pipradrol Tropanes 3α-Bis-4-fluorophenylmethoxytropane 3α-4-Chlorophenylphenylmethoxytropane 3-Pseudotropyl-4-fluorobenzoate Altropane IACFT Brasofensine CFT WIN 35,428 β-CIT RTI-55 Cocaethylene Cocaine β-CPPIT Dichloropane RTI-111 Difluoropine FE-β-CPPIT FP-β-CPPIT PIT PTT RTI-31 RTI-32 RTI-51 RTI-112 RTI-113 RTI-121 IPCIT RTI-126 RTI-150 RTI-171 RTI-177 RTI-336 Tesofensine Troparil β-CPT, WIN 35,065-2 WF-23 WF-33 WF-60 Xanthines Aminophylline Caffeine Dimethazan Paraxanthine Theobromine Theophylline Others Amineptine Bemegride Benzydamine BPAP Bromantane BTQ Clofenciclan Cypenamine Cyprodenate Diclofensine Dimethocaine Diphenyl prolinol Ethamivan Fencamfamine Feprosidnine Gilutensin GYKI-52895 Hexacyclonate Indanorex Indatraline LR-5182 Mazindol Mesocarb Naphthylisopropylamine Nikethamide Nomifensine Phthalimidopropiophenone Prolintane Sibutramine Yohimbine Zylofuramine See also Sympathomimetic amines v d e Psychoanaleptics: psychostimulants, agents used for ADHD and nootropics N06B Centrally acting sympathomimetics Amphetamine - Amphetaminil - Atomoxetine - Dextroamphetamine - Dextromethamphetamine - Fencamfamin - Fenozolone - Fenetylline - Methylphenidate - Mesocarb - Pemoline - Pipradrol - Prolintane Xanthine derivatives Caffeine - Propentofylline Glutamate receptor Racetams Aniracetam - Nefiracetam - Oxiracetam - Phenylpiracetam - Piracetam - Pramiracetam Ampakines CX-516 - CX-546 - CX-614 - CX-691 - CX-717 - IDRA-21 - LY-503,430 - PEPA Eugeroics / Benzhydryl compounds Adrafinil - Armodafinil - Modafinil Histamine H3 receptor antagonists ABT-239 - Ciproxifan Other psychostimulants and nootropics Acetylcarnitine - Citicoline - Cyprodenate - Idebenone - Ispronicline - Deanol - Dimebon - Fipexide - Linopirdine - Meclofenoxate - Nizofenone - Pirisudanol - Pyritinol - Sulbutiamine - Taltirelin - Tricyanoaminopropene - Vinpocetine Featured article Retrieved from http://en..org/wiki/Caffeine Categories: Featured articles | Caffeine | Coffee | Xanthines | Bitter compoundsHidden categories: Pages with DOIs broken since 2008 | All articles with statements | Articles with statements since March 2008 Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages العربية БългарÑ?ки Català Česky Cymraeg Dansk Deutsch Eesti Español Esperanto Ù?ارسی Français Gaeilge Galego í•œêµì–´ Hrvatski Ido Bahasa Indonesia Ã?slenska Italiano עברית ಕನà³?ನಡ LatvieÅ¡u Lietuvių Magyar Bahasa Melayu Nederlands 日本語 ‪Norsk bokmÃ¥l‬ ‪Norsk nynorsk‬ Polski Português Română РуÑ?Ñ?кий Shqip Simple English SlovenÄ?ina SlovenÅ¡Ä?ina СрпÑ?ки / Srpski Srpskohrvatski / СрпÑ?кохрватÑ?ки Suomi Svenska தமிழà¯? ไทย Tiếng Việt Türkçe УкраїнÑ?ька ייִדיש ä¸æ–‡ This page was last modified on 21 August 2008, at 03:51
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