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16-September-2008 16:15:14 - Acidosis It has been suggested that Metabolic acidosis be merged into this article or section. Discuss Acidosis Classification and external resources ICD-10 E87.2 ICD-9 276.2 DiseasesDB 87 MeSH D000138 For acidosis referring to acidity of the urine, see renal tubular acidosis. Acidosis is an increased acidity i.e. an increased hydrogen ion concentration. If not further qualified, it refers to acidity of the blood plasma. Acidosis is said to occur when arterial pH falls below 7.35, while its counterpart alkalosis occurs at a pH over 7.45. Arterial blood gas analysis and other tests are required to separate the main causes. The term acidemia describes the state of low blood pH, while acidosis is used to describe the processes leading to these states. Nevertheless, physicians sometimes use the terms interchangeably. The distinction may be relevant where a patient has factors causing both acidosis and alkalosis, where the relative severity of both determines whether the result is a high or a low pH. The rate of cellular metabolic activity affects and, at the same time, is affected by the pH of the body fluids. In mammals, the normal pH of arterial blood lies between 7.35 and 7.50 depending on the species e.g. healthy human-arterial blood pH varies between 7.35 and 7.45. Blood pH values compatible with life in mammals are limited to a pH range between 6.8 and 7.8. Changes in the pH of arterial blood and therefore the extracellular fluid outside this range result in irreversible cell damage Needham, 2004. Contents 1 Respiratory acidosis 2 Metabolic acidosis 3 See also 4 References 5 External links Respiratory acidosis Respiratory acidosis results from a build-up of carbon dioxide in the blood hypercapnia due to hypoventilation. It is most often caused by pulmonary problems, although head injuries, drugs especially anaesthetics and sedatives, and brain tumors can also bring it on. Pneumothorax, emphysema, chronic bronchitis, asthma, severe pneumonia, and aspiration are among the most frequent causes. It can also occur as a compensatory response to chronic metabolic alkalosis. One key to distinguish between respiratory and metabolic acidosis is that in respiratory acidosis, the CO2 is increased while the bicarbonate is either normal uncompensated or increased compensated. Compensation occurs if respiratory acidosis is present, and a chronic phase is entered with partial buffering of the acidosis through renal bicarbonate retention. However, in cases where chronic illnesses which compromise pulmonary function persist, such as late-stage emphysema and certain types of muscular dystrophy, compensatory mechanisms will be unable to reverse this acidotic condition. As metabolic bicarbonate production becomes exhausted, and extraeneous bicarbonate infusion can no longer reverse the extreme buildup of carbon dioxide associated with uncompensated respiratory acidosis, mechanical ventilation will usually be applied.12 Metabolic acidosis Metabolic acidosis is an increased production of metabolic acids, usually resulting from disturbances in the ability to excrete acid via the kidneys. Renal acidosis is associated with an accumulation of urea and creatinine as well as metabolic acid residues of protein catabolism. An increase in the production of other acids may also produce metabolic acidosis. For example, lactic acidosis may occur from 1 severe PaO2 36mm Hg hypoxemia causing a fall in the rate of oxygen diffusion from arterial blood to tissues, or 2 hypoperfusion e.g. hypovolemic shock causing an inadequate blood delivery of oxygen to tissues. A rise in lactate out of proportion to the level of pyruvate, e.g. in mixed venous blood, is termed excess lactate, and may also be an indicator of fermention due to anaerobic metabolism occurring in muscle cells, as seen during strenuous exercise. Once oxygenation is restored, the acidosis clears quickly. Another example of increased production of acids occurs in starvation and diabetic acidosis. It is due to the accumulation of ketoacids ketosis and reflects a severe shift from glycolysis to lipolysis for energy needs. Acid consumption from poisoning, elevated levels of iron in the blood, and chronically decreased production of bicarbonate may also produce metabolic acidosis. Metabolic acidosis is compensated for in the lungs, as increased exhalation of carbon dioxide promptly shifts the buffering equation to reduce metabolic acid. This is a result of stimulation to chemoreceptors which increases alveolar ventilation, leading to respiratory compensation, otherwise known as Kussmaul breathing a specific type of hyperventilation. Should this situation persist the patient is at risk for exhaustion leading to respiratory failure. Mutations to the V-ATPase 'a4' or 'B1' isoforms result in distal renal tubular acidosis, a condition that leads to metabolic acidosis, in some cases with sensorineural deafness. Arterial blood gasses will indicate low pH, low blood HCO3, and normal or low PaCO2. In addition to arterial blood gas, an anion gap can also differentiate between possible causes. The Henderson-Hasselbalch equation is useful for calculating blood pH, because blood is a buffer solution. The amount of metabolic acid accumulating can also be quantitated by using buffer base deviation, a derivative estimate of the metabolic as opposed to the respiratory component. In hypovolemic shock for example, approximately 50% of the metabolic acid accumulation is lactic acid, which disappears as blood flow and oxygen debt are corrected. Treatment of uncompensated metabolic acidosis is focused upon correcting the underlying problem. When metabolic acidosis is severe and can no longer be compensated for adequately by the lungs, neutralizing the acidosis with infusions of bicarbonate may be required. See also Alkalosis Acid-base physiology Acid-base homeostasis Mixed disorder of acid-base balance References Hobler KE, Carey LC. Effect of acute progressive hypoxemia on cardiac output and plasma excess lactate. Ann Surg. 1973 Feb;1772:199-202. Hobler KE, Napodano RJ, Tolerance of swine to acute blood volume deficits. J Trauma. 1974 Aug;148:716-8. Clinical Physiology of Acid-Base and Electrolyte Disorders by Rose, Post Intensive Care Medicine by Irwin and Rippe The ICU Book by Marino Needham, A. 2004. Comparative and Environmental Physiology Acidosis and Alkalosis. 3 External links National Kidney and Urologic Diseases Information Clearinghouse Look up Acidosis in Wiktionary, the free dictionary. v d e Water-electrolyte imbalance and acid-base imbalance E86-E87, 276 Volume status Dehydration/Hypervolemia - Hypovolemia Electrolyte Na+ Hypernatremia/Hyponatremia K+ Hyperkalemia/Hypokalemia Cl- Hyperchloremia/Hypochloremia Acid-base Acidosis: Metabolic - Respiratory - Lactic - Ketosis Alkalosis: Metabolic, Respiratory Mixed disorder of acid-base balance Retrieved from http://en..org/wiki/Acidosis Categories: Metabolic disorders | Electrolyte disturbances | Emergency medicine | Intensive care medicineHidden category: Articles to be merged since June 2008 Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages ÄŒesky Dansk Deutsch Español Français Galego Italiano Lietuvių Nederlands ‪Norsk bokmÃ¥l‬ Polski Português Română РуÑ?Ñ?кий SlovenÄ?ina Suomi Svenska Tagalog This page was last modified on 22 June 2008, at 11:55
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