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16-September-2008 16:15:15 - Acyl CoA dehydrogenase Acyl CoA dehydrogenase is the enzyme used to catalyze the first step of β-oxidation in Fatty acid metabolism. Contents 1 Reaction 2 Proteins 3 See also 4 External links Reaction The following reaction is the oxidation of the fatty acid by FAD. The enzyme catalyzes the formation of a double bond between the C-2 and C-3. The end product is trans-Δ2-enoyl-CoA. It is classified as EC 1.3.99.3. Proteins It is made up of the following proteins: Several of the units are classified by length, and some of those are associated with a particular metabolic disorder: Unit Chain Disorder ACADVL very long chain Very long-chain acyl-coenzyme A dehydrogenase deficiency VLCAD ACADL long chain - ACADM C-4 to C-12 straight chain medium chain Medium-chain acyl-coenzyme A dehydrogenase deficiency MCAD ACADS C-2 to C-3 short chain Short-chain acyl-coenzyme A dehydrogenase deficiency SCAD ACADSB short/branched chain - Other subunits include ACAD8, ACAD9, ACAD10 and ACAD11. See also Acyl CoA External links MeSH Acyl-CoA+Dehydrogenase v d e Protein: flavoproteins Acetolactate synthase - Acyl CoA dehydrogenase - Apoptosis-inducing factor - Butyryl CoA dehydrogenase - Cryptochrome - Cytochrome b5 reductase - Dihydrolipoamide dehydrogenase - Flavodoxin - Methemoglobin reductase - Methylenetetrahydrofolate reductase - NADH dehydrogenase - NADPH oxidase - Nitrate reductase - Sarcosine oxidase - Thioredoxin reductase v d e Oxidoreductases: CH-CH oxidoreductases EC 1.3 1.3.1. NAD/NADP acceptor Enoyl-acyl carrier protein reductase/Enoyl ACP reductase - 7-Dehydrocholesterol reductase - Biliverdin reductase - 2,4 Dienoyl-CoA reductase 1.3.3. Oxygen acceptor Dihydroorotate dehydrogenase - Coproporphyrinogen III oxidase - Protoporphyrinogen oxidase - 1.3.5. Quinone Succinate dehydrogenase 1.3.99. Other acceptors Fumarate reductase - Butyryl CoA dehydrogenase - Acyl CoA dehydrogenase ACADSB - 5-alpha reductase - Glutaryl-CoA dehydrogenase - Isovaleryl coenzyme A dehydrogenase v d e Metabolism: lipid metabolism - triglyceride and fatty acid enzymes Lipid production ATP citrate lyase - Acetyl-CoA carboxylase Fatty acid synthesis/Fatty acid synthase: Beta-ketoacyl-ACP synthase - Β-Ketoacyl ACP reductase - 3-Hydroxyacyl ACP dehydrase - Enoyl ACP reductase triacyl glycerol: Glycerol-3-phosphate dehydrogenase - Thiokinase Lipid degradation Acyl transport: Carnitine palmitoyltransferase I - Carnitine-acylcarnitine translocase - Carnitine palmitoyltransferase II Beta oxidation/Mitochondrial trifunctional protein: Acyl CoA dehydrogenase ACADL, ACADM, ACADS, ACADVL - Enoyl-CoA hydratase - 3-Hydroxyacyl CoA dehydrogenase - Acetyl-CoA C-acyltransferase to acetyl-CoA: Malonyl-CoA decarboxylase unsaturated Enoyl CoA isomerase, 2,4 Dienoyl-CoA reductase odd chain Propionyl-CoA carboxylase aldehydes Long-chain-aldehyde dehydrogenase see also disorders This enzyme-related article is a stub. Retrieved from http://en..org/wiki/Acyl_CoA_dehydrogenase Categories: Enzyme stubs Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Español Italiano This page was last modified on 7 May 2008, at 11:03
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