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16-September-2008 16:15:15 - Adipokine Merge arrow It has been suggested that this article or section be merged into Adipose tissue. Discuss The adipokines or adipocytokines are a group of cytokines cell-to-cell signalling proteins secreted by adipose tissue. Members include: chemerin1 interleukin-6 IL-62 plasminogen activator inhibitor-1 PAI-1 retinol binding protein 4 RBP4 tumor necrosis factor-alpha TNFα visfatin adiponectin, leptin Ob ligand, and resistin are not adipokines cytokines as they do not act on the immune system. These substances produced by adipocytes are hormones. Harrison's Principles of Internal Medicine. The definition of an adipokine is a cytokine produced by an adipocyte. A cytokine is a immunomodulating agent. Often in literature, proteins such as adiponectin, leptin, resistin are referred to as adipokines, however they can be more accurately put into the larger, growing list of adipose derived hormones. Their relative roles in modifying appetite, insulin resistance and atherosclerosis are the subjects of intense research, as they may be modifiable causes of morbidity in people with obesity.34 Notes ^ MacDougald1, Ormond A. and Burant, Charles F. September 2007 The Rapidly Expanding Family of Adipokines Cell Metabolism 6: pp. 159-161 ^ Monzillo, Lais U. 2003 Effect of Lifestyle Modification on Adipokine Levels in Obese Subjects with Insulin Resistance Obesity Research 119: pp. 1048-1054 ^ Matsuzawa, Yuji; Funahashi, Tohru and Nakamura, Tadashi 1999 Molecular Mechanism of Metabolic Syndrome X: Contribution of Adipocytokines - Adipocyte-derived Bioactive Substances Annals of the New York Academy of Sciences 892: pp. 146-54 Abstract ^ Funahashi, T. et al. 1999 Role of adipocytokines on the pathogenesis of atherosclerosis in visceral obesity Internal Medicine Japan 38: pp. 202-206 Abstract This cell biology article is a stub. Retrieved from http://en..org/wiki/Adipokine Categories: Cytokines | Cell biology stubsHidden category: Articles to be merged since September 2007 Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Česky This page was last modified on 3 June 2008, at 08:16
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