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16-September-2008 16:15:15 - Adjudin Medicine or the Medicine Portal may be able to help recruit one. If a more appropriate or portal exists, please adjust this template accordingly. Adjudin AF-2364, also 1-2,4-dichlorobenzyl-1H-indazole-3-carbohydrazide, is an analogue of lonidamine, an indazole-carboxylic acid. According to a May 1, 2007 news article by science writer Robert Finn in the twice-monthly newspaper Ob.Gyn.News about a presentation Future Contraception: What's in the Pipeline? by nurse-practitioner and nurse-midwife Sharon Schnare on March 8, 2007 at the Contemporary Forums Contraceptive Technology conference in San Francisco, Adjudin is currently in phase II human trials.1 As shown in mature male rats, the agent induces reversible germ cell loss from the seminiferous epithelium by disrupting cell adhesion function between Sertoli and germ cells.2 It weakens the adhesion between the Sertoli cell and maturing sperm leading to a sloughing and loss of the latter.3 As it does not affect spermatogonia themselves the loss of fertility is reversible. In experiments hormonal levels FSH, LH, testosterone were undisturbed during administration, and normal spermatogenesis returned in 95% of the tubules of rats at 210 days after the drug had been discontinued.4 When taken orally, the drug has very low bioavailability. The oral dose effective for contraception is so high that there have been side effects in the muscles and liver. Coupling an Adjudin molecule to a mutant form of follicle-stimulating hormone may solve this problem.5 The mutant FSH is modified such that it not longer induces Inhibin B production, but the membrane-bound FSH receptors on Sertoli cells still bind to it, delivering the Adjudin directly to the target cells. References ^ Robert Finn. Male Contraceptive Methods Are in the Pipeline. Ob.Gyn. News 42:28, May 1, 2007. Full text PDF ^ Dolores D. Mruk and C. Yan Cheng. Sertoli-Sertoli and Sertoli-Germ Cell Interactions and Their Significance in Germ Cell Movement in the Seminiferous Epithelium during Spermatogenesis. Endocrine Reviews 2004 25 5: 747-806 ^ Cheng CY, Mruk D, Silvestrini B, Bonanomi M, Wong CH, Siu MK, Lee NP, Lui WY, Mo MY. AF-2364 1-2,4-dichlorobenzyl-1H-indazole-3-carbohydrazide is a potential male contraceptive: a review of recent data. Contraception. 2005 Oct;724:251-61. PMID 16181968 ^ Grima J, Silvestrini B, Cheng CY. Reversible inhibition of spermatogenesis in rats using a new male contraceptive, 1-2,4-dichlorobenzyl-indazole-3-carbohydrazide. Biol Reprod. 2001 May;645:1500-8. PMID 11319158 ^ Future male 'pill' targets testicles New Scientist, 29 October 2006, citing Mruk DD, Wong CH, Silvestrini B, Cheng CY. A male contraceptive targeting germ cell adhesion. Nature Medicine advance access 29 October 2006 DOI: 10.1038/nm1420 External links Trials for alternative male Pill show no side-effects at the Independent Sperm-stopping male pill hope at BBC News Adjudin a Lonidamine analogue at MaleContraceptives.org Tablets This pharmacology-related article is a stub. Retrieved from http://en..org/wiki/Adjudin Categories: Pharmacology stubs | Contraception for males | Experimental methods of birth controlHidden categories: Medicine articles needing expert attention | Articles needing expert attention | Pages needing expert attention Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Español This page was last modified on 6 June 2008, at 17:01
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