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16-September-2008 16:15:15 - medulla Adrenal medulla Medulla labeled at bottom right. Gray's subject #277 1280 Artery superior suprarenal artery, middle suprarenal artery, Inferior suprarenal artery Vein suprarenal veins Nerve celiac plexus, renal plexus Lymph lumbar glands Precursor Neural crest Medullary part of the adrenal gland on the pointer. Medullary part of the adrenal gland on the pointer. The adrenal medulla is part of the adrenal gland. It is located at the center of the gland, being surrounded by the adrenal cortex. Contents 1 Function 2 Origin 3 Pathology 4 See also 5 References 6 External links Function Composed mainly of hormone-producing chromaffin cells, the adrenal medulla is the principal site of the conversion of the amino acid tyrosine into the catecholamines adrenaline epinephrine, noradrenaline norepinephrine, and dopamine. In response to stressors such as exercise or imminent danger, medullary cells release catecholamines into the blood in an 17:3 ratio of adrenaline to noradrenaline.1 Notable effects of adrenaline and noradrenaline include increased heart rate and blood pressure, blood vessel constriction, bronchiole dilation, and increased metabolism, all of which are characteristic of the fight-or-flight response. Release of catecholamines is stimulated by nerve impulses, and receptors for catecholamines are widely distributed throughout the body. Origin Medullary cells are derived from the embryonic neural crest and, as such, are simply modified neurons. In particular, they are modified postganglionic cells of the sympathetic nervous system that have lost their axons and dendrites, receiving innervation from corresponding preganglionic fibers. Moreover, as the synapses between pre- and postganglionic fibers are called ganglia, the adrenal medulla is actually a ganglion of the sympathetic nervous system. Pathology Neoplasms including: Pheochromocytoma most common a catecholamine-secreting tumor of the adrenal medulla Neuroblastoma a neuroendocrine tumor of any neural crest tissue of the sympathetic nervous system Ganglioneuroma a tumor in the nerve cells of the peripheral nervous system See also Adrenal gland References ^ Anatomy at UMich intro_autonomics_2_module/autonomics_05 External links SUNY Labs 40:04-0202 - Posterior Abdominal Wall: Blood Supply to the Suprarenal Glands Anatomy Atlases - Microscopic Anatomy, plate 15.292 - Adrenal Gland Location of Adrenal medulla v d e Endocrine system Adrenal glands Medulla Chromaffin cells Cortex Zona glomerulosa Zona fasciculata Zona reticularis Retrieved from http://en..org/wiki/Adrenal_medulla Categories: Glands | Abdomen | Endocrine system Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Italiano Polski This page was last modified on 31 May 2008, at 12:43

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